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The neural basis of disturbed efference copy mechanism in patients with schizophrenia

The neural basis of disturbed efference copy mechanism in patients with schizophrenia Core psychopathological symptoms in patients with schizophrenia suggest that their sense of self may be disturbed. A disturbance in predictive motor mechanisms may be the cause of such symptoms. Ten patients with schizophrenia and ten healthy right-handed control subjects opened and closed their hand. This movement was filmed with an MRI compatible video camera and projected online onto a monitor. BOLD contrast was measured with fMRI. The temporal delay between movement and feedback was parametrically varied. Participants judged whether or not there was a delay. Patients were less sensitive to these delays than a matched control group. Comparing neural activation between the two groups showed a reduced attenuation of movement-sensitive perceptual areas in patients with increasing delay and a higher activation in the putamen in controls. The results provide further evidence that impaired efference copy mechanisms may contribute to the pathogenesis of schizophrenia and its first rank symptoms. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cognitive Neuroscience Taylor & Francis

The neural basis of disturbed efference copy mechanism in patients with schizophrenia

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References (26)

Publisher
Taylor & Francis
Copyright
Copyright 2010 Psychology Press, an imprint of the Taylor & Francis Group, an Informa business
ISSN
1758-8936
eISSN
1758-8928
DOI
10.1080/17588921003646156
pmid
24168277
Publisher site
See Article on Publisher Site

Abstract

Core psychopathological symptoms in patients with schizophrenia suggest that their sense of self may be disturbed. A disturbance in predictive motor mechanisms may be the cause of such symptoms. Ten patients with schizophrenia and ten healthy right-handed control subjects opened and closed their hand. This movement was filmed with an MRI compatible video camera and projected online onto a monitor. BOLD contrast was measured with fMRI. The temporal delay between movement and feedback was parametrically varied. Participants judged whether or not there was a delay. Patients were less sensitive to these delays than a matched control group. Comparing neural activation between the two groups showed a reduced attenuation of movement-sensitive perceptual areas in patients with increasing delay and a higher activation in the putamen in controls. The results provide further evidence that impaired efference copy mechanisms may contribute to the pathogenesis of schizophrenia and its first rank symptoms.

Journal

Cognitive NeuroscienceTaylor & Francis

Published: Jun 2, 2010

Keywords: Corollary discharge; Basal ganglia; Functional imaging; Psychiatry; Forward model

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