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Serum neurofilament light concentration does not increase following exposure to low velocity football heading

Serum neurofilament light concentration does not increase following exposure to low velocity... Objectives: To investigate if heading frequency and impact biomechanics in a single session influence the concentration of serum neurofilament light (NF-L), a sensitive biomarker for axonal damage, up to 7 days after heading incident at ball velocities reflecting basic training drills. Methods: Forty-four males were randomized into either control (n = 8), 10 header (n = 12), 20 header (n = 12) or 40 header (n = 12) groups. Linear and angular head accelerations were quantified during heading. Venous blood samples were taken at baseline, 6 h, 24 h and 7 days after heading. Serum NF-L was quantified using Quanterix NF-L assay kit on the Simoa HD-1 Platform. Results: Serum NF-L did not alter over time (p = 0.44) and was not influenced by number of headers [p = 0.47; mean (95% CI) concentrations at baseline 6.00 pg · ml− 1 (5.00–7.00 pg · ml− 1); 6 h post 6.50 pg · ml−1 (5.70–7.29 pg · ml−1); 24 h post 6.07 pg · ml−1 (5.14–7.01 pg · ml− 1); and 7 days post 6.46 pg · ml−1 (5.45–7.46 pg · ml−1)]. There was no relationship between percentage change in NF-L and summed session linear and angular head accelerations. Conclusion: In adult men, heading frequency or impact biomechanics did not affect NF-L response during a single session of headers at ball velocities reflective of basic training tasks. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Science and Medicine in Football Taylor & Francis

Serum neurofilament light concentration does not increase following exposure to low velocity football heading

Serum neurofilament light concentration does not increase following exposure to low velocity football heading

Science and Medicine in Football , Volume 5 (3): 7 – Jul 3, 2021

Abstract

Objectives: To investigate if heading frequency and impact biomechanics in a single session influence the concentration of serum neurofilament light (NF-L), a sensitive biomarker for axonal damage, up to 7 days after heading incident at ball velocities reflecting basic training drills. Methods: Forty-four males were randomized into either control (n = 8), 10 header (n = 12), 20 header (n = 12) or 40 header (n = 12) groups. Linear and angular head accelerations were quantified during heading. Venous blood samples were taken at baseline, 6 h, 24 h and 7 days after heading. Serum NF-L was quantified using Quanterix NF-L assay kit on the Simoa HD-1 Platform. Results: Serum NF-L did not alter over time (p = 0.44) and was not influenced by number of headers [p = 0.47; mean (95% CI) concentrations at baseline 6.00 pg · ml− 1 (5.00–7.00 pg · ml− 1); 6 h post 6.50 pg · ml−1 (5.70–7.29 pg · ml−1); 24 h post 6.07 pg · ml−1 (5.14–7.01 pg · ml− 1); and 7 days post 6.46 pg · ml−1 (5.45–7.46 pg · ml−1)]. There was no relationship between percentage change in NF-L and summed session linear and angular head accelerations. Conclusion: In adult men, heading frequency or impact biomechanics did not affect NF-L response during a single session of headers at ball velocities reflective of basic training tasks.

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References (33)

Publisher
Taylor & Francis
Copyright
© 2020 Informa UK Limited, trading as Taylor & Francis Group
ISSN
2473-4446
eISSN
2473-3938
DOI
10.1080/24733938.2020.1853210
Publisher site
See Article on Publisher Site

Abstract

Objectives: To investigate if heading frequency and impact biomechanics in a single session influence the concentration of serum neurofilament light (NF-L), a sensitive biomarker for axonal damage, up to 7 days after heading incident at ball velocities reflecting basic training drills. Methods: Forty-four males were randomized into either control (n = 8), 10 header (n = 12), 20 header (n = 12) or 40 header (n = 12) groups. Linear and angular head accelerations were quantified during heading. Venous blood samples were taken at baseline, 6 h, 24 h and 7 days after heading. Serum NF-L was quantified using Quanterix NF-L assay kit on the Simoa HD-1 Platform. Results: Serum NF-L did not alter over time (p = 0.44) and was not influenced by number of headers [p = 0.47; mean (95% CI) concentrations at baseline 6.00 pg · ml− 1 (5.00–7.00 pg · ml− 1); 6 h post 6.50 pg · ml−1 (5.70–7.29 pg · ml−1); 24 h post 6.07 pg · ml−1 (5.14–7.01 pg · ml− 1); and 7 days post 6.46 pg · ml−1 (5.45–7.46 pg · ml−1)]. There was no relationship between percentage change in NF-L and summed session linear and angular head accelerations. Conclusion: In adult men, heading frequency or impact biomechanics did not affect NF-L response during a single session of headers at ball velocities reflective of basic training tasks.

Journal

Science and Medicine in FootballTaylor & Francis

Published: Jul 3, 2021

Keywords: Soccer; heading; brain injury; axonal damage; biomechanics

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