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Neural bases of motivated forgetting of autobiographical memories

Neural bases of motivated forgetting of autobiographical memories It is important for mental health to be able to control unwanted intrusive memories. Previous studies suggest that middle frontal gyrus (MFG) down regulates pathways underlie the suppression of retrieval of general memories. However, the neural basis of motivated forgetting of autobiographical memories is unclear. Therefore, this study used two samples to explore the neural mechanisms of motivated forgetting of self-referential memories. Every participant provided 40 life events (20 negative and 20 neutral) from their past personal experience, and then completed the Think/No-Think task while undergoing functional magnetic resonance imaging (fMRI). The first sample showed a significant reduction in recall in the No-Think condition relative to the Think condition. Attempting to exclude negative autobiographical memories from awareness was associated with increased activity in the right MFG, superior frontal gyrus (SFG), and inferior frontal gyrus (IFG), while reduced activity was observed in the bilateral Brodmann areas BA18 and BA19, bilateral medial prefrontal cortex (mPFC), bilateral precuneus, bilateral post cingulate cortex (PCC), the left parahippocampus, and the left hippocampus. Functional connectivity analyses showed that the right MFG projected into the bilateral mPFC, bilateral precuneus, and bilateral middle occipital gyrus (MOG) for negative autobiographical memories. The second sample replicated the results of the first sample at both the behavioral and brain levels. These results suggest that retrieval suppression of autobiographical memories involve the pathway between the MFG and the mPFC and precuneus to exclude self-referential memories. These results reveal how people engage in motivated forgetting of negative events in their daily lives. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cognitive Neuroscience Taylor & Francis

Neural bases of motivated forgetting of autobiographical memories

Lu, FengYing; Yang, WenJing; Qiu, Jiang
Cognitive Neuroscience , Volume 14 (1): 10 – Jan 2, 2023
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Neural bases of motivated forgetting of autobiographical memories

Abstract

It is important for mental health to be able to control unwanted intrusive memories. Previous studies suggest that middle frontal gyrus (MFG) down regulates pathways underlie the suppression of retrieval of general memories. However, the neural basis of motivated forgetting of autobiographical memories is unclear. Therefore, this study used two samples to explore the neural mechanisms of motivated forgetting of self-referential memories. Every participant provided 40 life events (20 negative...
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Publisher
Taylor & Francis
Copyright
© 2022 Informa UK Limited, trading as Taylor & Francis Group
ISSN
1758-8936
eISSN
1758-8928
DOI
10.1080/17588928.2022.2136150
Publisher site
See Article on Publisher Site

Abstract

It is important for mental health to be able to control unwanted intrusive memories. Previous studies suggest that middle frontal gyrus (MFG) down regulates pathways underlie the suppression of retrieval of general memories. However, the neural basis of motivated forgetting of autobiographical memories is unclear. Therefore, this study used two samples to explore the neural mechanisms of motivated forgetting of self-referential memories. Every participant provided 40 life events (20 negative and 20 neutral) from their past personal experience, and then completed the Think/No-Think task while undergoing functional magnetic resonance imaging (fMRI). The first sample showed a significant reduction in recall in the No-Think condition relative to the Think condition. Attempting to exclude negative autobiographical memories from awareness was associated with increased activity in the right MFG, superior frontal gyrus (SFG), and inferior frontal gyrus (IFG), while reduced activity was observed in the bilateral Brodmann areas BA18 and BA19, bilateral medial prefrontal cortex (mPFC), bilateral precuneus, bilateral post cingulate cortex (PCC), the left parahippocampus, and the left hippocampus. Functional connectivity analyses showed that the right MFG projected into the bilateral mPFC, bilateral precuneus, and bilateral middle occipital gyrus (MOG) for negative autobiographical memories. The second sample replicated the results of the first sample at both the behavioral and brain levels. These results suggest that retrieval suppression of autobiographical memories involve the pathway between the MFG and the mPFC and precuneus to exclude self-referential memories. These results reveal how people engage in motivated forgetting of negative events in their daily lives.

Journal

Cognitive Neuroscience – Taylor & Francis

Published: Jan 2, 2023

Keywords: Memory control; Think/No-Think; autobiographical memories; fMRI

References

  • Prefrontal-hippocampal pathways underlying inhibitory control over memory
  • Suppressing unwanted memories by executive control
  • Neural mechanisms of motivated forgetting
  • Neural systems underlying the suppression of unwanted memories
  • Opposing mechanisms support the voluntary forgetting of unwanted memories
  • Reducing future fears by suppressing the brain mechanisms underlying episodic simulation
  • Self-disorders in individuals with attenuated psychotic symptoms: Contribution of a dysfunction of autobiographical memory
  • Brain activity during episodic retrieval of autobiographical and laboratory events: An fMRI study using a novel photo paradigm
  • The effect of retrieval focus and emotional valence on the medial temporal lobe activity during autobiographical recollection
  • Prefrontal - hippocampal interaction: An integrative review and model of the Think/No-Think task with implications for psychiatric conditions
  • Prefrontal regions orchestrate suppression of emotional memories via a two-phase process
  • The organization of right Prefrontal networks reveals common mechanisms of inhibitory regulation across cognitive, emotional, and motor processes
  • Parallel regulation of memory and emotion supports the suppression of intrusive memories
  • Mental imagery of positive and neutral memories: A fMRI study comparing field perspective imagery to observer perspective imagery
  • Repression and the unconscious
  • It’s all in the detail: Intentional forgetting of autobiographical memories using the autobiographical think/no-think task
  • To think or not to think, that is the question: Individual differences in suppression and rebound effects in autobiographical memory
  • Neural correlates of direct and indirect suppression of autobiographical memories
  • Preserved functional specialization for spatial processing in the middle occipital gyrus of the early blind
  • Hippocampal GABA enables inhibitory control over unwanted thoughts
  • Savoring the past: Positive memories evoke value representations in the striatum
  • Suppression-induced reduction in the specificity of autobiographical memories
  • The neural correlates of trauma-related autobiographical memory in posttraumatic stress disorder: A meta-analysis
  • Autobiographical memory specificity and emotional disorder
  • Memory in the hippocampus