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Epigenetic regulation in radiation-induced pulmonary fibrosis

Epigenetic regulation in radiation-induced pulmonary fibrosis Abstract Purpose Radiation-induced pulmonary fibrosis (RIPF) is a common and serious adverse effect of radiotherapy for thoracic tumors, which occurs in the irreversible stage of radiation-induced lung injury (RILI) >6 months after irradiation. It is characterized by progressive and irreversible destruction of lung tissue and deterioration of lung function, which may impair quality of life and lead to respiratory failure and death. We hope this will draw attention to the involvement of epigenetics in the regulation of RIPF. Conclusions This review summarizes research progress on the role and mechanism of DNA methylation, noncoding RNA and RNA methylation in RIPF or RILI, and the possible role and mechanism of histone modification in RIPF. We have noticed that in tissue fibrosis, the epigenetic regulation mechanisms inside and outside the nucleus can influence each other. We speculate that RIPF may be regulated by an epigenetic regulatory network during its development, and believe that TGF-β, SNAIL, PTEN and EZH2 are four targets worthy of in-depth study. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Radiation Biology Taylor & Francis

Epigenetic regulation in radiation-induced pulmonary fibrosis

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References (76)

Publisher
Taylor & Francis
Copyright
Copyright © 2022 Taylor & Francis Group LLC.
ISSN
1362-3095
eISSN
0955-3002
DOI
10.1080/09553002.2022.2089365
Publisher site
See Article on Publisher Site

Abstract

Abstract Purpose Radiation-induced pulmonary fibrosis (RIPF) is a common and serious adverse effect of radiotherapy for thoracic tumors, which occurs in the irreversible stage of radiation-induced lung injury (RILI) >6 months after irradiation. It is characterized by progressive and irreversible destruction of lung tissue and deterioration of lung function, which may impair quality of life and lead to respiratory failure and death. We hope this will draw attention to the involvement of epigenetics in the regulation of RIPF. Conclusions This review summarizes research progress on the role and mechanism of DNA methylation, noncoding RNA and RNA methylation in RIPF or RILI, and the possible role and mechanism of histone modification in RIPF. We have noticed that in tissue fibrosis, the epigenetic regulation mechanisms inside and outside the nucleus can influence each other. We speculate that RIPF may be regulated by an epigenetic regulatory network during its development, and believe that TGF-β, SNAIL, PTEN and EZH2 are four targets worthy of in-depth study.

Journal

International Journal of Radiation BiologyTaylor & Francis

Published: Mar 4, 2023

Keywords: Epigenetic; radiation-induced pulmonary fibrosis; DNA methylation; Histone modification; non-coding RNA; RNA methylation

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