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- Publisher
- Springer Journals
- Copyright
- 2011 Pleiades Publishing, Ltd.
- ISSN
- 1063-7745
- eISSN
- 1562-689X
- DOI
- 10.1134/s1063774511040122
- Publisher site
- See Article on Publisher Site
Abstract
Abstract The activation of xenobiotics often causes malignant tumor cells to resist chemotherapeutic treatment. Uridine phosphorylase is the key enzyme of pyrimidine metabolism and catalyzes the reversible phosphorylation of uridine with the formation of uracil and ribose-1-phosphate. High-selectivity anticancer agents based on uridine phosphorylase inhibitors are promising for treating both oncological and infection diseases. New medicinal preparations can be predicted and rationally developed only on the basis of detailed biomedical, structural, and functional knowledge about the biomacromolecular target enzyme-drug complex.
Journal
Crystallography Reports – Springer Journals
Published: Jul 1, 2011
Keywords: Crystallography and Scattering Methods