Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Update on the Pathogenic Mechanisms of Isocyanate-induced Asthma

Update on the Pathogenic Mechanisms of Isocyanate-induced Asthma REVIEW ARTICLE Update on the Pathogenic Mechanisms of Isocyanate-induced Asthma Gyu-Young Hur, MD,* Sung-Jin Choi, MD,* Seung-Youp Shin, MD,Þ Sang-Ha Kim, MD, PhD,þ and Hae-Sim Park, MD, PhD* asthmatic patients had experienced persistent asthmatic Background: The pathogenic mechanisms of toluene diisocyanate symptoms even after cessation of exposure to isocyanate. (TDI)Yinduced asthma are not understood clearly. The pathogenic mechanism of occupational asthma is Methods: In this review, we summarized recent data to further complicated by the fact that both immunologic and non- understand the pathogenic mechanisms through recent approach of immunologic pathways may be involved, depending upon the molecular genetic studies, and specific antibody responses to 3Y6 causative agent. In addition, several environmental factors, cellular mechanisms. including the nature of the causative agent and the level and Results: Genetic polymorphism studies suggested the involvement of mode of exposure, affect the pathogenesis of occupational oxidant/antioxidant-related genes and neurogenic inflammatory asthma. In cases involving low-molecular-weight chemicals, response genes. A high-resolution technique of HLA allele suggested particularly TDI, both immunoglobulin E (IgE)Y and non- some HLA genetic markers presenting the phenotype of TDI-induced 3Y7 IgEYmediated pathways have been implicated. Several asthma. The new volatile type of TDIYhuman serum albumin studies examining the role http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png World Allergy Organization Journal Springer Journals

Update on the Pathogenic Mechanisms of Isocyanate-induced Asthma

Download PDF
4 pages

Loading next page...
 
/lp/springer-journals/update-on-the-pathogenic-mechanisms-of-isocyanate-induced-asthma-dgA0A8tIHO

References (53)

Publisher
Springer Journals
Copyright
Copyright © 2008 by World Allergy Organization; licensee BioMed Central Ltd.
Subject
Medicine & Public Health; Allergology; Immunology
eISSN
1939-4551
DOI
10.1097/wox.0b013e3181625d8c
pmid
23283297
Publisher site
See Article on Publisher Site

Abstract

REVIEW ARTICLE Update on the Pathogenic Mechanisms of Isocyanate-induced Asthma Gyu-Young Hur, MD,* Sung-Jin Choi, MD,* Seung-Youp Shin, MD,Þ Sang-Ha Kim, MD, PhD,þ and Hae-Sim Park, MD, PhD* asthmatic patients had experienced persistent asthmatic Background: The pathogenic mechanisms of toluene diisocyanate symptoms even after cessation of exposure to isocyanate. (TDI)Yinduced asthma are not understood clearly. The pathogenic mechanism of occupational asthma is Methods: In this review, we summarized recent data to further complicated by the fact that both immunologic and non- understand the pathogenic mechanisms through recent approach of immunologic pathways may be involved, depending upon the molecular genetic studies, and specific antibody responses to 3Y6 causative agent. In addition, several environmental factors, cellular mechanisms. including the nature of the causative agent and the level and Results: Genetic polymorphism studies suggested the involvement of mode of exposure, affect the pathogenesis of occupational oxidant/antioxidant-related genes and neurogenic inflammatory asthma. In cases involving low-molecular-weight chemicals, response genes. A high-resolution technique of HLA allele suggested particularly TDI, both immunoglobulin E (IgE)Y and non- some HLA genetic markers presenting the phenotype of TDI-induced 3Y7 IgEYmediated pathways have been implicated. Several asthma. The new volatile type of TDIYhuman serum albumin studies examining the role

Journal

World Allergy Organization Journal – Springer Journals

Published: Jan 15, 2008

There are no references for this article.