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- Copyright © 2019 by Springer Science+Business Media, LLC, part of Springer Nature
- Subject
- Medicine & Public Health; Allergology
- ISSN
- 1529-7322
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- 10.1007/s11882-019-0874-2
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Abstract
Purpose of the Review This review aims at presenting the most significant data obtained in the field of the genetics of autoinflammatory disorders (AID) over the last past 5 years. Recent Findings More than 15 genes have been implicated in AID since 2014, unveiling new pathogenic pathways. Recent data have revealed atypical modes of transmission in several inherited AID, such as somatic mosaicism and digenism. First pieces of evidence showing an involvement of epigenetic modifications in the pathogenesis of AID have also been brought to light. Novel genetic data have been obtained on the molecular bases of genetically complex AID. Summary The development of next-generation sequencing in routine clinical practice has led to an explosion in the identification of new AID genes. Advances in the knowledge of AID further blur the limits between monogenic and multifactorial forms of these syndromes, and between autoinflammatory and autoimmune conditions. . . . . . Keywords Autoinflammatory diseases Genetics Gene Mosaicism Digenism Epigenetics Introduction dysfunction of the innate immune system. One of the main discoveries was that of the inflammasome, a mac- The concept of autoinflammatory diseases (AID) was initially romolecular pro-inflammatory complex, which is consti- proposed, as opposed to autoimmune diseases, with
Journal
Current Allergy and Asthma Reports – Springer Journals
Published: Jul 18, 2019