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Atsushi Kihara, H. Yoshida, R. Watanabe, Kenta Takahashi, Tomoyasu Kato, Y. Ino, M. Kitagawa, N. Hiraoka (2017)
Clinicopathologic Association and Prognostic Value of Microcystic, Elongated, and Fragmented (MELF) Pattern in Endometrial Endometrioid CarcinomaThe American Journal of Surgical Pathology, 41
E. Becht, Nicolas Giraldo, M. Dieu-Nosjean, C. Sautès-Fridman, W. Fridman (2016)
Cancer immune contexture and immunotherapy.Current opinion in immunology, 39
Xiang Zheng, Kati Turkowski, Javier Mora, B. Brüne, W. Seeger, A. Weigert, R. Savai (2017)
Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapyOncotarget, 8
C. Stewart, M. Crook (2010)
Galectin-3 Expression in Uterine Endometrioid Adenocarcinoma: Comparison of Staining in Conventional Tumor Glands and in Areas of MELF Pattern Myometrial InvasionInternational Journal of Gynecological Pathology, 29
Sakiko Kojiro-Sanada, Kaori Yasuda, S. Nishio, S. Ogasawara, J. Akiba, K. Ushijima, H. Yano (2017)
CXCL14-CXCR4 and CXCL12-CXCR4 Axes May Play Important Roles in the Unique Invasion Process of Endometrioid Carcinoma With MELF-Pattern MyoinvasionInternational Journal of Gynecological Pathology, 36
H. Pegram, N. Haynes, M. Smyth, M. Kershaw, P. Darcy (2010)
Characterizing the anti-tumor function of adoptively transferred NK cells in vivoCancer Immunology, Immunotherapy, 59
Jo Janco, Purushottam Lamichhane, L. Karyampudi, K. Knutson (2015)
Tumor-Infiltrating Dendritic Cells in Cancer PathogenesisThe Journal of Immunology, 194
WB Slayton, Z Hu (2010)
Tumor microenvironment
E. Becht, Nicolas Giraldo, C. Germain, A. Reyniès, P. Laurent-Puig, J. Zucman‐Rossi, M. Dieu-Nosjean, C. Sautès-Fridman, W. Fridman (2016)
Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers.Advances in immunology, 130
M. Naki, Gülbin Oran, Seza Tetikkurt, Cavide Sönmez, I. Türkmen, F. Köse (2017)
Microcystic, elongated, and fragmented pattern of invasion in relation to histopathologic and clinical prognostic factors in endometrioid endometrial adenocarcinomaJournal of the Turkish German Gynecological Association, 18
D. Zinovkin, M. Pranjol (2016)
Tumor-Infiltrated Lymphocytes, Macrophages, and Dendritic Cells in Endometrioid Adenocarcinoma of Corpus Uteri as Potential Prognostic Factors: An Immunohistochemical StudyInternational Journal of Gynecologic Cancer, 26
M. Şancı, K. Güngördük, V. Gülseren, T. Karadeniz, M. Kocaer, O. Gungorduk, İ. Özdemir (2017)
MELF Pattern for Predicting Lymph Node Involvement and Survival in Grade I-II Endometrioid-type Endometrial CancerInternational Journal of Gynecological Pathology, 37
R. Seager, Cynthia Hajal, F. Spill, F. Spill, R. Kamm, M. Zaman, M. Zaman (2017)
Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression.Convergent science physical oncology, 3
M. Shurin, R. Salter (2009)
Dendritic cells in cancer
E. Levy, M. Bianchini, Erika Euw, M. Barrio, A. Bravo, D. Furman, E. Domenichini, C. Macagno, Victor Pinsky, C. Zucchini, L. Valvassori, J. Mordoh (2008)
Human leukocyte antigen-E protein is overexpressed in primary human colorectal cancer.International journal of oncology, 32 3
Hong Jiang, Samarth Hegde, D. DeNardo (2017)
Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapyCancer Immunology, Immunotherapy, 66
S. Ha, So-Young Yeo, Yan-hiua Xuan, Seok-Hyung Kim (2014)
The Prognostic Significance of Cancer-Associated Fibroblasts in Esophageal Squamous Cell CarcinomaPLoS ONE, 9
D Zinovkin, MZI Pranjol (2016)
Tumor-infiltrated lymphocytes, macrophages, and dendritic cells in endometrioid adenocarcinoma of corpus uteri as potential prognostic factorsInt J Gynecol Cancer, 26
Ang Yuan, Jeremy J.‐W. Chen, Pan‐Chyr Yang (2008)
Advances in Clinical Chemistry
D. Zinovkin, M. Pranjol, D. Petrenyov, E. Nadyrov, O. Savchenko (2017)
The Potential Roles of MELF-Pattern, Microvessel Density, and VEGF Expression in Survival of Patients with Endometrioid Endometrial Carcinoma: A Morphometrical and Immunohistochemical Analysis of 100 CasesJournal of Pathology and Translational Medicine, 51
M. Stakheyeva, V. Riabov, I. Mitrofanova, N. Litviakov, E. Choynzonov, N. Cherdyntseva, J. Kzhyshkowska (2017)
Role of the Immune Component of Tumor Microenvironment in the Efficiency of Cancer Treatment: Perspectives for the Personalized Therapy.Current pharmaceutical design, 23 32
W. Fridman, F. Pagès, C. Sautès-Fridman, J. Galon (2012)
The immune contexture in human tumours: impact on clinical outcomeNature Reviews Cancer, 12
K. Dietl, K. Renner, K. Dettmer, Birgit Timischl, K. Eberhart, C. Dorn, C. Hellerbrand, M. Kastenberger, L. Kunz-Schughart, P. Oefner, R. Andreesen, E. Gottfried, M. Kreutz (2009)
Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human MonocytesThe Journal of Immunology, 184
C. Stewart, L. Little (2009)
Immunophenotypic features of MELF pattern invasion in endometrial adenocarcinoma: evidence for epithelial–mesenchymal transitionHistopathology, 55
G. Dunn, A. Bruce, H. Ikeda, L. Old, R. Schreiber (2002)
Cancer immunoediting: from immunosurveillance to tumor escapeNature Immunology, 3
CJ Stewart, ML Crook (2010)
Galectin-3 expression in uterine endometrioid adenocarcinomaInt J Gynecol Pathol, 29
W. Slayton, Zhongbo Hu (2010)
Bone Marrow Stroma and the Leukemic Microenvironment
D. Quail, J. Joyce (2013)
Microenvironmental regulation of tumor progression and metastasisNature Medicine, 19
Etienne Becht, Nicolas A. Giraldo, Claire Germain, Aurélien de Reyniès, Pierre Laurent-Puig, Jessica Zucman-Rossi, Marie-Caroline Dieu-Nosjean, Catherine Sautès-Fridman, Wolf H. Fridman (2016)
Advances in Immunology
A. Bakakos, E. Oikonomou, G. Vogiatzi, G. Siasos, S. Tsalamandris, A. Antonopoulos, C. Mourouzis, P. Fountoulakis, M. Vavuranakis, D. Tousoulis (2017)
Statins and left ventricular function.Current pharmaceutical design
Almut Brand, K. Singer, G. Koehl, M. Kolitzus, G. Schoenhammer, A. Thiel, Carina Matos, C. Bruss, S. Klobuch, K. Peter, M. Kastenberger, C. Bogdan, U. Schleicher, A. Mackensen, E. Ullrich, S. Fichtner-Feigl, R. Kesselring, M. Mack, U. Ritter, M. Schmid, C. Blank, K. Dettmer, P. Oefner, P. Hoffmann, S. Walenta, E. Geissler, J. Pouysségur, A. Villunger, A. Steven, B. Seliger, S. Schreml, S. Haferkamp, E. Kohl, S. Karrer, M. Berneburg, W. Herr, W. Mueller‐Klieser, K. Renner, M. Kreutz (2016)
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.Cell metabolism, 24 5
D. Spaner, A. Bahlo (2011)
B Lymphocytes in Cancer Immunology
G. Pasqual, A. Chudnovskiy, J. Tas, M. Agudelo, Lawrence Schweitzer, Ang Cui, N. Hacohen, G. Victora (2018)
Monitoring T cell–dendritic cell interactions in vivo by intercellular enzymatic labellingNature, 553
L. Tashireva, V. Perelmuter, V. Manskikh, E. Denisov, O. Savelieva, E. Kaygorodova, M. Zavyalova, M. Zavyalova (2017)
Types of immune-inflammatory responses as a reflection of cell–cell interactions under conditions of tissue regeneration and tumor growthBiochemistry (Moscow), 82
D Spaner, A Bahlo (2011)
Experimental and applied immunotherapy
P. Maluf, M. Michelin, R. Etchebehere, S. Adad, E. Murta (2008)
T lymphocytes (CD3) may participate in the recurrence of cervical intraepithelial neoplasia grade IIIArchives of Gynecology and Obstetrics, 278
S. Biswas, A. Sica, C. Lewis (2008)
Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms1The Journal of Immunology, 180
A. Petty, Yiping Yang (2017)
Tumor-associated macrophages: implications in cancer immunotherapy.Immunotherapy, 9 3
A. Yuan, Jeremy Chen, Pan‐Chyr Yang (2008)
Pathophysiology of tumor-associated macrophages.Advances in clinical chemistry, 45
Microcystic, elongated, fragmented (MELF)-pattern is an unusual morphology of myometrial invasive front in endometrioid endometrial carcinoma (EA). The aim of the study was to investigate potential correlation between MELF-pattern and peritumoral inflammatory immune response. A total of 96 out of 368 patients were included in this study. CD3, CD20, CD57. CD68 and S100 markers were used for the detection of tumor-associated T-lymphocytes (TAT), tumor-associated B-lymphocytes (TAB), tumor-associated NK-lymphocytes (NK), tumor-associated macrophages and dendritic cells respectively. Mann-Whitney tests, receiver operating characteristic (ROC) curve analysis, and Spearman correlation were used as methods for statistical analyses. Odds ratio with 95% confidence interval (95% CI) was determined with the use of a logistic regression model. A p < 0.05 was considered statistically significant. Our results suggested that the number of CD3 and CD68 cells were significantly lower (p < 0.001) in cases of endometrioid carcinoma with MELF-pattern. A significant correlation between the presence of MELF-pattern and decrease of CD3 positive T-lymphocytes (r = 0.691; p < 0.001) was also observed. Additionally, we found an inverse correlation between the presence of MELF-pattern and TAM (r = 0.568; p = 0.001). Therefore, our data suggest that MELF-pattern may be associated with EA stroma fibrosis that contains immune cells infiltration and demonstrated a decrease in the number of TAT and TAM cells. This may indicate the poor clinical prognosis of this disease.
Cancer Microenvironment – Springer Journals
Published: Jul 14, 2018
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