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Am J Cardiovasc Drugs 2010; 10 (4): 265-266 CORRESPONDENCE 1175-3277/10/0004-0265/$49.95/0 ª 2010 Adis Data Information BV. All rights reserved. Following 30 minutes’ preincubation at 25C, PON1 activity Trimetazidine Activates [13] was measured spectrophotometrically with phenylacetate. The mean of three values (triplicate) was calculated and data Paraoxonase were analyzed using the paired Student’s t-test. Thus, each of the five groups (with 0, 25, 50, 75 and 100 mmol/L trimetazidine In an article published in this journal last year, Iyengar and concentration) consisted of 30 mean values (one from each [1] Rosano concluded: ‘‘The inclusion of trimetazidine in the individual). antianginal treatment of stable angina is independently asso- PON1 activity in the control group (without trimetazidine) ciated with a significant reduction in mortality after surviving was 95.59 – 6.11 U/mL and, with increasing trimetazidine con- an MI.’’ Guidelines on the management of stable angina pec- centrations of 25, 50, 75 and 100 mmol/L, PON1 activity increased toris suggest that trimetazidine might be used, where available, to 103.77– 6.40 U/mL (p= 0.000004 vs control), 115.27– 6.90 U/mL as add-on therapy, or as substitution therapy when conven- (p< 0.000001 vs previous group), 125.67– 6.31 U/mL (p< 0.000001 [2] tional drugs are not tolerated
American Journal of Cardiovascular Drugs – Springer Journals
Published: Aug 17, 2012
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