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editorial memo (2013) 6:5–8 DOI 10.1007/s12254-013-0070-3 Treatment results for children and adolescents with acute myeloid leukemia in Middle and Eastern European countries Ursula Creutzig, Gesche Tallen Received: 14 January 2013 / Accepted: 21 January 2013 / Published online: 15 February 2013 © Springer-Verlag Wien 2013 Ursula Creutzig Acute myeloid leukemia (AML) corresponds to a hetero- The key of success in treating pediatric leukemias in geneous group of hematologic neoplasms that originate high-income Western European countries during the from bone marrow precursors of the myeloid, mono- past decades has been the conduct of clinical studies, cyte, erythroid, and megakaryocytic cell lineages. While the concept of which is based on the comparative testing acute lymphoblastic leukemia (ALL) remains the most of the effectiveness of multimodal treatment concepts common childhood malignancy, AML comprises only (rather than on studying the efficacy of a single drug) as about 4.8 % of all pediatric cancers in Europe. However, well as on patient stratification into specific risk groups although an orphan disease and despite of remarkable according to the individual morphology, histochemistry, advances during the past decades in both the manage- immunophenotype and genetic subtype of the disease. ment and the understanding of the biology and
memo - Magazine of European Medical Oncology – Springer Journals
Published: Feb 15, 2013
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