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(2004)
Is breast cancer survival improving? Cancer
D. Blanchard, P. Shetty, S. Hilsenbeck, R. Elledge (2008)
Association of Surgery With Improved Survival in Stage IV Breast Cancer PatientsAnnals of Surgery, 247
Stage IV breast
S. Giordano, A. Buzdar, T. Smith, S. Kau, Ying Yang, G. Hortobagyi (2004)
Is breast cancer survival improving?Cancer, 100
G. Babiera, R. Rao, Lei Feng, F. Meric-Bernstam, H. Kuerer, S. Singletary, K. Hunt, M. Ross, K. Gwyn, B. Feig, F. Ames, G. Hortobagyi (2006)
Effect of Primary Tumor Extirpation in Breast Cancer Patients Who Present With Stage IV Disease and an Intact Primary TumorAnnals of Surgical Oncology, 13
Fatima Cardoso, A. Leo, Caroline Lohrisch, Chantal Bernard, Fábio Ferreira, Martine Piccart (2002)
Second and subsequent lines of chemotherapy for metastatic breast cancer: what did we learn in the last two decades?Annals of oncology : official journal of the European Society for Medical Oncology, 13 2
J. Folkman (1974)
Proceedings: Tumor angiogenesis factor.Cancer research, 34 8
R. Scodan, D. Stevens, E. Brain, J. Floiras, C. Cohen-Solal, B. Lande, M. Tubiana-Hulin, S. Yacoub, M. Gutiérrez, D. Ali, M. Gardner, P. Moisson, S. Villette, F. Lerebours, J. Munck, A. Labib (2009)
Breast cancer with synchronous metastases: survival impact of exclusive locoregional radiotherapy.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 27 9
Erika Danna, P. Sinha, M. Gilbert, V. Clements, B. Pulaski, S. Ostrand-Rosenberg (2004)
Surgical Removal of Primary Tumor Reverses Tumor-Induced Immunosuppression Despite the Presence of Metastatic DiseaseCancer Research, 64
S. Dawood, S. Dawood, K. Broglio, J. Ensor, G. Hortobagyi, S. Giordano (2010)
Survival differences among women with de novo stage IV and relapsed breast cancer.Annals of oncology : official journal of the European Society for Medical Oncology, 21 11
A. Bafford, H. Burstein, Christina Barkley, Barbara Smith, S. Lipsitz, J. Iglehart, E. Winer, M. Golshan (2009)
Breast surgery in stage IV breast cancer: impact of staging and patient selection on overall survivalBreast Cancer Research and Treatment, 115
(2012)
what did we learn in the last two decades? Ann Oncol
H. Neuman, M. Morrogh, M. Gonen, K. Zee, M. Morrow, T. King (2010)
Stage IV breast cancer in the era of targeted therapyCancer, 116
S. Khan, A. Stewart, M. Morrow (2002)
Does aggressive local therapy improve survival in metastatic breast cancer?Surgery, 132 4
J. Wagner, G. Babiera (2008)
Surgical Removal of the Primary Tumor Increases Overall Survival in Patients With Metastatic Breast Cancer: Analysis of the 1988-2003 SEER DataBreast Diseases: A Year Book Quarterly, 19
A. Karnoub, A. Dash, A. Vo, Andrew Sullivan, M. Brooks, G. Bell, A. Richardson, K. Polyak, R. Tubo, R. Weinberg (2007)
Mesenchymal stem cells within tumour stroma promote breast cancer metastasisNature, 449
J Ruiterkamp, MF Ernst, LV Poll-Franse (2009)
Surgical resection of the primary tumour is associated with improved survival in patients with distant metastatic breast cancer at diagnosisEur J Surg Oncol, 35
R. Fields, D. Jeffe, K. Trinkaus, Q. Zhang, Carey Arthur, R. Aft, J. Dietz, T. Eberlein, W. Gillanders, J. Margenthaler (2007)
Surgical Resection of the Primary Tumor is Associated with Increased Long-Term Survival in Patients with Stage IV Breast Cancer after Controlling for Site of MetastasisAnnals of Surgical Oncology, 14
R. Kaplan, R. Riba, S. Zacharoulis, Anna Bramley, L. Vincent, Carla Costa, Daniel MacDonald, D. Jin, K. Shido, Scott Kerns, Zhen-ping Zhu, D. Hicklin, Yan Wu, J. Port, N. Altorki, Elisa Port, D. Ruggero, S. Shmelkov, Kristian Jensen, S. Rafii, D. Lyden (2005)
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic nicheNature, 438
M. Campbell, Janet Scott, H. Maecker, John Park, L. Esserman (2005)
Immune dysfunction and micrometastases in women with breast cancerBreast Cancer Research and Treatment, 91
B. Cady, B. Cady, N. Nathan, J. Michaelson, M. Golshan, Barbara Smith (2008)
Matched Pair Analyses of Stage IV Breast Cancer with or Without Resection of Primary Breast SiteAnnals of Surgical Oncology, 15
S. Khan (2011)
Stage IV Breast Cancer in the Era of Targeted Therapy: Does Surgery of the Primary Tumor Matter?Breast Diseases: A Year Book Quarterly, 22
L. Dominici, J. Najita, M. Hughes, J. Niland, P. Marcom, Y. Wong, Bradford Carter, S. Javid, S. Edge, H. Burstein, M. Golshan (2011)
Surgery of the primary tumor does not improve survival in stage IV breast cancerBreast Cancer Research and Treatment, 129
J. Ruiterkamp, M. Ernst, L. Poll-Franse, K. Bosscha, V. Tjan-Heijnen, A. Voogd (2009)
5005 Surgical resection of the primary tumour is associated with improved survival in patients with distant metastatic breast cancer at diagnosisEjc Supplements, 7
H. Hazard, S. Gorla, D. Scholtens, K. Kiel, W. Gradishar, S. Khan (2008)
Surgical resection of the primary tumor, chest wall control, and survival in women with metastatic breast cancerCancer, 113
A. Soran, S. Ozbas, S. Kelsey, B. Gulluoglu (2009)
Randomized Trial Comparing Locoregional Resection of Primary Tumor with No Surgery in Stage IV Breast Cancer at the Presentation (Protocol MF07‐01): A Study of Turkish Federation of the National Societies for Breast DiseasesThe Breast Journal, 15
J. Folkman (1985)
Tumor angiogenesis.Advances in cancer research, 43
S. Gainer, G. Babiera (2009)
Surgical Resection of the Primary Tumor, Chest Wall Control, and Survival in Women With Metastatic Breast CancerBreast Diseases: A Year Book Quarterly, 20
J Gnerlich, DB Jeffe, AD Deshpande (2007)
Surgical removal of the primary tumor increases overall survival in patients with metastatic breast cancer: analysis of the 1988–2003 SEER dataAnn Surg Oncol, 14
S. Dawood, K. Broglio, A. González-Angulo, A. Buzdar, G. Hortobagyi, S. Giordano (2008)
Trends in survival over the past two decades among white and black patients with newly diagnosed stage IV breast cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 26 30
C. Daniel, G. Babiera (2009)
Surgical Resection of the Primary Tumor is Associated with Increased Long-Term Survival in Patients with Stage IV Breast Cancer after Controlling for Site of MetastasisBreast Diseases: A Year Book Quarterly, 19
L. Norton (1991)
Metastatic breast cancer. Length and quality of life.The New England journal of medicine, 325 19
F. André, K. Slimane, T. Bachelot, A. Dunant, M. Namer, Alain Barrelier, O. Kabbaj, J. Spano, H. Marsiglia, R. Rouzier, S. Delaloge, M. Spielmann (2004)
Breast cancer with synchronous metastases: trends in survival during a 14-year period.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 22 16
M. Clarke, R. Collins, S. Darby, C. Davies, P. Elphinstone, V. Evans, J. Godwin, R. Gray, C. Hicks, S. James, E. Mackinnon, P. Mcgale, T. McHugh, R. Peto, Carolyn Taylor, Yaochen Wang (2005)
Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trialsThe Lancet, 366
R. Flanigan, S. Salmon, B. Blumenstein, S. Bearman, V. Roy, P. Mcgrath, J. Caton, N. Munshi, E. Crawford (2001)
Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer.The New England journal of medicine, 345 23
T. Shien, T. Kinoshita, C. Shimizu, T. Hojo, N. Taira, H. Doihara, S. Akashi-Tanaka (2009)
Primary tumor resection improves the survival of younger patients with metastatic breast cancer.Oncology reports, 21 3
E. Rapiti, H. Verkooijen, G. Vlastos, G. Fioretta, I. Neyroud‐Caspar, A. Sappino, P. Chappuis, C. Bouchardy (2006)
Complete excision of primary breast tumor improves survival of patients with metastatic breast cancer at diagnosis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24 18
A. Leung, H. Vu, K. Nguyen, L. Thacker, H. Bear (2010)
Effects of surgical excision on survival of patients with stage IV breast cancer.The Journal of surgical research, 161 1
Surgical removal of the intact primary breast tumor for patients who present with stage IV disease remains controversial. The classical view is that resection of the intact primary will have no survival benefit in stage IV disease; however, resection may prevent the development of uncontrolled chest wall disease. Multiple retrospective reviews have compared survival in stage IV patients who do or do not undergo resection of the intact primary, and have demonstrated longer survival with the use of primary site surgery. These are all compromised by the selection of women with favorable characteristics for surgical therapy and the inability to confirm important disease and treatment parameters in registry and retrospective data. Additionally, there are no data that allow examination of the value of radiotherapy in addition to surgery. These important questions cannot be addressed without Level 1 evidence, and randomized trials comparing primary site therapy versus none are ongoing.
Current Breast Cancer Reports – Springer Journals
Published: Mar 23, 2012
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