The management of multiple myeloma (MM) has undergone many developments in the last 30 years. Initially, melphalan was used as a single agent and this was followed by the discovery of corticosteroids as highly active agents and the design of multiagent cytotoxic regimens. However, although response rates have improved, little impact has been achieved on survival. Interferon has been extensively examined in early as well as relapsed disease. Currently, a benefit in survival is only evident in maintenance phase, where there is a small but significant difference. However, this has to be evaluated in the context of adverse effects and the impact on quality of life.
American Journal of Cancer – Springer Journals
Published: Aug 10, 2012
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.