Access the full text.
Sign up today, get DeepDyve free for 14 days.
Sacha Khong, K. Andrews, N. Huynh, K. Venardos, A. Aprico, D. Michell, M. Zarei, K. Moe, G. Dusting, D. Kaye, J. Chin-Dusting (2012)
Arginase II inhibition prevents nitrate toleranceBritish Journal of Pharmacology, 166
C. Yancy, M. Jessup, B. Bozkurt, J. Butler, D. Casey, Monica Colvin, M. Drazner, G. Filippatos, G. Fonarow, M. Givertz, S. Hollenberg, J. Lindenfeld, F. Masoudi, P. Mcbride, Pamela Peterson, L. Stevenson, C. Westlake (2017)
2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America.Journal of the American College of Cardiology, 70 6
A. Daiber, T. Münzel (2015)
Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative StressAntioxidants & Redox Signaling, 23
T. Johal, C. Lees, T. Everett, I. Wilkinson (2014)
The nitric oxide pathway and possible therapeutic options in pre‐eclampsiaBritish Journal of Clinical Pharmacology, 78
K. Matsushita, Benjamin Marchandot, A. Carmona, A. Curtiaud, Anis Idrissi, A. Trimaille, M. Kibler, T. Cardi, J. Heger, S. Hess, A. Reydel, L. Jesel, P. Ohlmann, O. Morel (2020)
Increased susceptibility to SARS‐CoV‐2 infection in patients with reduced left ventricular ejection fractionESC Heart Failure, 8
T. Münzel, H. Sayegh, B. Freeman, M. Tarpey, D. Harrison (1995)
Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.The Journal of clinical investigation, 95 1
K. Sydow, A. Daiber, M. Oelze, Zhiqiang Chen, M. August, M. Wendt, V. Ullrich, A. Mülsch, Eberhard Schulz, J. Keaney, J. Stamler, T. Münzel (2004)
Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance.The Journal of clinical investigation, 113 3
M. Packer (1990)
What causes tolerance to nitroglycerin? The 100 year old mystery continues.Journal of the American College of Cardiology, 16 4
C. Yancy, M. Jessup, B. Bozkurt, J. Butler, D. Casey, Monica Colvin, M. Drazner, G. Filippatos, G. Fonarow, M. Givertz, S. Hollenberg, J. Lindenfeld, F. Masoudi, P. Mcbride, Pamela Peterson, L. Stevenson, C. Westlake (2017)
2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America.Circulation, 136 6
G. Abou‐Mohamed, W. Kaesemeyer, R. Caldwell, R. Caldwell (2000)
Role of L‐arginine in the vascular actions and development of tolerance to nitroglycerinBritish Journal of Pharmacology, 130
L. Garavilla, E. Pagani, R. Buchholz, R. Dundore, D. Bode, M. Volberg, K. Jackson, P. Pratt, P. Silver (1992)
Zaprinast, but not dipyridamole, reverses hemodynamic tolerance to nitroglycerin in vivo.European journal of pharmacology, 313 1-2
(Diagnosing Adult Growth Hormone Deficiency, https://ClinicalTrials.gov/show/NCT03018886, Accessed: 04 December 2020. https://ClinicalTrials.gov/show/NCT03018886.)
Diagnosing Adult Growth Hormone Deficiency, https://ClinicalTrials.gov/show/NCT03018886, Accessed: 04 December 2020. https://ClinicalTrials.gov/show/NCT03018886.Diagnosing Adult Growth Hormone Deficiency, https://ClinicalTrials.gov/show/NCT03018886, Accessed: 04 December 2020. https://ClinicalTrials.gov/show/NCT03018886., Diagnosing Adult Growth Hormone Deficiency, https://ClinicalTrials.gov/show/NCT03018886, Accessed: 04 December 2020. https://ClinicalTrials.gov/show/NCT03018886.
Juan Rey, J. Caro-Codón, Sandra Rosillo, A. Iniesta, Sergio Castrejón-Castrejón, I. Marco-Clement, L. Martín‐Polo, C. Merino-Argos, L. Rodríguez‐Sotelo, Jose García‐Veas, L. Martinez-Marin, M. Martinez-Cossiani, A. Buño, Luis Gonzalez‐Valle, Alicia Herrero, José López‐Sendón, J. Merino, Jose Mart, J. Merino, J. Caro-Codón, Sergio Castrejón-Castrejón, A. Iniesta, M. Martinez-Cossiani, C. Merino, L. Martín‐Polo, L. Martinez, I. Marco, Jose García‐Veas, L. Rodríguez‐Sotelo, Sandra Rosillo, José López‐Sendón, Juan Rey, J. Rios, J. Arribas, F. Arnalich, C. Prados, R. Alvarez-Sala, M. Quintana, A. Lorenzo, F. Reinoso, Angelica Rivera, Rosario Torres, J. García-Rodríguez, Luis Gonzalez‐Valle, Alicia Herrero, A. Borobia, A. Buño (2020)
Heart failure in COVID‐19 patients: prevalence, incidence and prognostic implicationsEuropean Journal of Heart Failure, 22
(1888)
Remarkable tolerance to nitroglycerin
G. Abou‐Mohamed, John Johnson, Liming Jin, A. El-Remessy, K. Do, W. Kaesemeyer, R. Caldwell, R. Caldwell (2004)
Roles of Superoxide, Peroxynitrite, and Protein Kinase C in the Development of Tolerance to NitroglycerinJournal of Pharmacology and Experimental Therapeutics, 308
(1996)
Zaprinast, but not dipyridamole, reverses hemodynamic tolerance to nitroglycerin in vivoEur J Pharmacol, 313
D. Giugliano, R. Marfella, G. Verrazzo, R. Acampora, Cosimo Donzella, A. Quatraro, L. Coppola, F. D'onofrio (1995)
Abnormal Rheologic Effects of Glyceryl Trinitrate in Patients with Non-Insulin-Dependent Diabetes Mellitus and Reversal by AntioxidantsAnnals of Internal Medicine, 123
J. Esplugues, M. Rocha, Cristina Núñez, I. Bosca, S. Ibiza, J. Herance, Ángel Ortega, J. Serrador, P. D’Ocon, V. Víctor (2006)
Complex I Dysfunction and Tolerance to Nitroglycerin: An Approach Based on Mitochondrial-Targeted AntioxidantsCirculation Research, 99
M. Oelze, M. Knorr, Richard Schell, J. Kamuf, A. Pautz, J. Art, P. Wenzel, T. Münzel, H. Kleinert, A. Daiber (2011)
Regulation of Human Mitochondrial Aldehyde Dehydrogenase (ALDH-2) Activity by Electrophiles in Vitro*The Journal of Biological Chemistry, 286
Dongsoo Kim, S. Rybalkin, Xinchun Pi, Yining Wang, Changxi Zhang, T. Munzel, J. Beavo, B. Berk, C. Yan (2001)
Upregulation of Phosphodiesterase 1A1 Expression Is Associated With the Development of Nitrate ToleranceCirculation: Journal of the American Heart Association, 104
(2004)
Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-toleranceJ Clin Investig., 113
B. Bennett, B. McDonald, R. Nigam, W. Simon (1994)
Biotransformation of organic nitrates and vascular smooth muscle cell function.Trends in pharmacological sciences, 15 7
Mao Mao, Sudhahar Varadarajan, T. Fukai, Farnaz Bakhshi, O. Chernaya, S. Dudley, R. Minshall, M. Bonini (2014)
Nitroglycerin Tolerance in Caveolin-1 Deficient MicePLoS ONE, 9
M. Bonini, K. Stadler, Sueli Silva, J. Corbett, Michael Doré, J. Petranka, D. Fernandes, L. Tanaka, D. Duma, F. Laurindo, R. Mason (2008)
Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilationProceedings of the National Academy of Sciences, 105
M. Packer, W. Lee, P. Kessler, S. Gottlieb, N. Medina, M. Yushak (1987)
Prevention and reversal of nitrate tolerance in patients with congestive heart failure.The New England journal of medicine, 317 13
R. Yeates, M. Schmid (1992)
Total prevention of the development of in vitro tolerance to organic nitrates. Experiments with antioxidants.Arzneimittel-Forschung, 42 3
(2005)
Explaining the phenomenon of nitrate tolerance.Circulation research, 97 7
Diagnosing Adult Growth Hormone Deficiency
C. Yancy, M. Jessup, B. Bozkurt, J. Butler, D. Casey, Monica Colvin, M. Drazner, G. Filippatos, G. Fonarow, M. Givertz, S. Hollenberg, J. Lindenfeld, F. Masoudi, P. Mcbride, Pamela Peterson, L. Stevenson, C. Westlake (2017)
2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America.Journal of cardiac failure, 23 8
D. Tomasoni, R. Inciardi, C. Lombardi, Chiara Tedino, P. Agostoni, P. Ameri, L. Barbieri, A. Bellasi, R. Camporotondo, C. Canale, V. Carubelli, S. Carugo, Francesco Catagnano, L. Vecchia, G. Danzi, Mattia Pasquale, M. Gaudenzi, S. Giovinazzo, M. Gnecchi, A. Iorio, M. Rovere, S. Leonardi, G. Maccagni, M. Mapelli, Davide Margonato, M. Merlo, L. Monzo, A. Mortara, V. Nuzzi, M. Piepoli, I. Porto, A. Pozzi, F. Sarullo, G. Sinagra, M. Volterrani, G. Zaccone, M. Guazzi, M. Senni, M. Metra (2020)
Impact of heart failure on the clinical course and outcomes of patients hospitalized for COVID‐19. Results of the Cardio‐COVID‐Italy multicentre studyEuropean Journal of Heart Failure, 22
W. Kaesemeyer, A. Ogonowski, L. Jin, R. Caldwell, R. Caldwell (2000)
Endothelial nitric oxide synthase is a site of superoxide synthesis in endothelial cells treated with glyceryl trinitrateBritish Journal of Pharmacology, 131
U. Elkayam, F. Bitar, M. Akhter, Salman Khan, Saber Patrus, Mahyar Derakhshani (2004)
Intravenous Nitroglycerin in the Treatment of Decompensated Heart Failure: Potential Benefits and LimitationsJournal of Cardiovascular Pharmacology and Therapeutics, 9
T. Suvorava, W. Kaesemeyer (2020)
TARGETING THE VASCULAR ENDOTHELIUM IN THE TREATMENT OF COVID-19.Journal of Cardiovascular Pharmacology
Athena Cavounidis, E. Mann (2020)
SARS-CoV-2 has a sweet toothNature Reviews. Immunology, 20
P. Wenzel, U. Hink, M. Oelze, S. Schuppan, Karin Schaeuble, S. Schildknecht, K. Ho, H. Weiner, M. Bachschmid, T. Münzel, A. Daiber (2007)
Role of Reduced Lipoic Acid in the Redox Regulation of Mitochondrial Aldehyde Dehydrogenase (ALDH-2) ActivityJournal of Biological Chemistry, 282
G. Doolub, C. Wong, L. Hewitson, A. Mohamed, F. Todd, L. Gogola, A. Skyrme-Jones, S. Aziz, E. Sammut, A. Dastidar (2021)
Impact of COVID‐19 on inpatient referral of acute heart failure: a single‐centre experience from the south‐west of the UKESC Heart Failure, 8
Liansheng Wang, Yongzhen Yang, S. Dwivedi, Ya Xu, Etem Chu, Jie Li, K. Fitchett, P. Boor (2007)
Manipulating glutathione-S-transferases may prevent the development of tolerance to nitroglycerinCardiovascular Toxicology, 6
Zhiqiang Chen, Jian Zhang, J. Stamler (2002)
Identification of the enzymatic mechanism of nitroglycerin bioactivationProceedings of the National Academy of Sciences of the United States of America, 99
K. Kugiyama, M. Ohgushi, T. Motoyama, O. Hirashima, H. Soejima, K. Misumi, M. Yoshimura, Hisao Ogawa, S. Sugiyama, Hirofumi Yasue (1998)
Intracoronary infusion of reduced glutathione improves endothelial vasomotor response to acetylcholine in human coronary circulation.Circulation, 97 23
A. Rolo, C. Palmeira (2006)
Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress.Toxicology and applied pharmacology, 212 2
The purpose of this current opinion article is to illustrate a novel approach to the treatment of acute decompensated heart failure (ADHF) in coronavirus disease 2019 (COVID-19) patients. The approach described herein relies on a reformulation of intravenous nitroglycerin in 5% glutathione, itself novel, and is felt to have the potential to not only improve the rate of resolution of ADHF, but also reduce the risk of complications of heart failure seen in patients with COVID-19.
American Journal of Cardiovascular Drugs – Springer Journals
Published: Nov 1, 2021
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.