Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Towards Semi-Automatic Reconstruction of Neural Circuits

Towards Semi-Automatic Reconstruction of Neural Circuits Neuroinform (2013) 11:31–33 DOI 10.1007/s12021-012-9166-x COMMENTARY Towards Semi-Automatic Reconstruction of Neural Circuits Albert Cardona Published online: 6 October 2012 © Springer Science+Business Media New York 2012 Imaging a complete brain at nanometer resolution Keywords Neural circuit · Electron microscopy · has proven troublesome. FIBSEM has so far demon- Reconstruction strated that excellent, continuous and isotropic vol- umes of small brain volumes can be obtained if the The spatial layout of neuronal arbors and their synapses in the brain, also known as the wiring diagram or the connectome, may provide the basis for for- mulating experimentally testable hypotheses of neural circuit function. In the brain, the small dimensions of Lichtman, J.W., & Sanes, J.R. (2008). Ome sweet ome: what can terminal dendrites and synapses, and the anatomical the genome tell us about the connectome? Current Opinion of flexibility of neuronal arbors implementing the same Neurobiology, 18, 346–353. function in the brains of two different individuals, con- Bargmannn, C.I. (2012). Beyond the connectome: how neuro- modulators shape neural circuits. Bioessays, 34(6), 458–465. spire against the standard scientific approach of exam- Briggman, K.L., & Bock, D.D. (2011). Volume electron mi- ining a small piece of tissue and generalizing to the rest. croscopy http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroinformatics Springer Journals

Towards Semi-Automatic Reconstruction of Neural Circuits

Neuroinformatics , Volume 11 (1) – Oct 6, 2012

Loading next page...
 
/lp/springer-journals/towards-semi-automatic-reconstruction-of-neural-circuits-igPJxNriY0
Publisher
Springer Journals
Copyright
Copyright © 2012 by Springer Science+Business Media New York
Subject
Biomedicine; Neurosciences; Bioinformatics; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Neurology
ISSN
1539-2791
eISSN
1559-0089
DOI
10.1007/s12021-012-9166-x
pmid
23055046
Publisher site
See Article on Publisher Site

Abstract

Neuroinform (2013) 11:31–33 DOI 10.1007/s12021-012-9166-x COMMENTARY Towards Semi-Automatic Reconstruction of Neural Circuits Albert Cardona Published online: 6 October 2012 © Springer Science+Business Media New York 2012 Imaging a complete brain at nanometer resolution Keywords Neural circuit · Electron microscopy · has proven troublesome. FIBSEM has so far demon- Reconstruction strated that excellent, continuous and isotropic vol- umes of small brain volumes can be obtained if the The spatial layout of neuronal arbors and their synapses in the brain, also known as the wiring diagram or the connectome, may provide the basis for for- mulating experimentally testable hypotheses of neural circuit function. In the brain, the small dimensions of Lichtman, J.W., & Sanes, J.R. (2008). Ome sweet ome: what can terminal dendrites and synapses, and the anatomical the genome tell us about the connectome? Current Opinion of flexibility of neuronal arbors implementing the same Neurobiology, 18, 346–353. function in the brains of two different individuals, con- Bargmannn, C.I. (2012). Beyond the connectome: how neuro- modulators shape neural circuits. Bioessays, 34(6), 458–465. spire against the standard scientific approach of exam- Briggman, K.L., & Bock, D.D. (2011). Volume electron mi- ining a small piece of tissue and generalizing to the rest. croscopy

Journal

NeuroinformaticsSpringer Journals

Published: Oct 6, 2012

There are no references for this article.