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M. Porta, E. Puigdomènech, F. Ballester, Javier Selva, N. Ribas‐Fitó, S. Llop, Tomás López (2008)
Monitoring concentrations of persistent organic pollutants in the general population: the international experience.Environment international, 34 4
Isela Velazquez, B. Alter (2004)
Androgens and liver tumors: Fanconi's anemia and non‐Fanconi's conditionsAmerican Journal of Hematology, 77
United Nations Environment Programme UNEP (2003)
United Nations Environment Programme UNEP (2003).
D. Lee, Inkuk Lee, Kyungeun Song, M. Steffes, William Toscano, Beth Baker, D. Jacobs (2006)
A Strong Dose-Response Relation Between Serum Concentrations of Persistent Organic Pollutants and DiabetesDiabetes Care, 29
P. Aseni, C. Sansalone, C. Sammartino, F. Benedetto, G. Carrafiello, A. Giacomoni, C. Osio, M. Vertemati, D. Forti (2001)
Rapid Disappearance of Hepatic Adenoma After Contraceptive WithdrawalJournal of Clinical Gastroenterology, 33
MB Fischer (1996)
Regulation of the B cell response to T-dependent antigens by classical pathway complementCarroll. J. Immunol., 157
J. Chevrier, B. Eskenazi, A. Bradman, L. Fenster, D. Barr (2007)
Associations between Prenatal Exposure to Polychlorinated Biphenyls and Neonatal Thyroid-Stimulating Hormone Levels in a Mexican-American Population, Salinas Valley, CaliforniaEnvironmental Health Perspectives, 115
S. Shimizu, Y. Eguchi, H. Kosaka, W. Kamiike, H. Matsuda, Y. Tsujimoto (1995)
Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xLNature, 374
M. Sakaguchi, M. Miyazaki, Y. Inoue, T. Tsuji, Hirosuke Kouchi, Toshio Tanaka, H. Yamada, M. Namba (2000)
Relationship between Contact Inhibition and Intranuclear S100c of Normal Human FibroblastsThe Journal of Cell Biology, 149
M. Sakaguchi, H. Yamada, T. Tsuji, Y. Inoue, M. Miyazaki, T. Tanaka, M. Namba (2001)
Loss of Nuclear Localization of the S100C Protein in Immortalized Human Fibroblasts, 155
V Vetvicka BP Thornton (1996)
Function of C3 in a humoral response: iC3b/C3dg bound to an immune complex generated with natural antibody and a primary antigen promotes antigen uptake and the expression of co-stimulatory molecules by all B cells, but only stimulates immunoglobulin synthesis by antigen-specific B cellsClin. Exp. Immunol., 104
N. Hirokawa, Y. Noda, Y. Okada (1998)
Kinesin and dynein superfamily proteins in organelle transport and cell division.Current opinion in cell biology, 10 1
D. Guc, P. Gulati, C. Lemercier, D. Lappin, G. Birnie, K. Whaley (2004)
Expression of the components and regulatory proteins of the alternative complement pathway and the membrane attack complex in normal and diseased synoviumRheumatology International, 13
K. Bifulco, I. Longanesi-Cattani, L. Gargiulo, O. Maglio, M. Cataldi, M. Rosa, M. Stoppelli, V. Pavone, M. Carriero (2008)
An urokinase receptor antagonist that inhibits cell migration by blocking the formyl peptide receptorFEBS Letters, 582
A. Echard, F. Jollivet, Olivier Martinez, J. Lacapere, A. Rousselet, I. Janoueix-Lerosey, B. Goud (1998)
Interaction of a Golgi-associated kinesin-like protein with Rab6.Science, 279 5350
M. Ikeda, S. Okada, H. Ueno, T. Okusaka, H. Kuriyama (2001)
Spontaneous regression of hepatocellular carcinoma with multiple lung metastases: a case report.Japanese journal of clinical oncology, 31 9
D. Vaux, S. Cory, Jerry Adams (1988)
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cellsNature, 335
Min-Kyeong Yeo, Hyung-Geun Park (2012)
Gene expression in zebrafish embryos following exposure to Cu-doped TiO2 and pure TiO2 nanometer-sized photocatalystsMolecular & Cellular Toxicology, 8
N. Ribas‐Fitó, M. Sala, M. Kogevinas, J. Sunyer (2001)
Polychlorinated biphenyls (PCBs) and neurological development in children: a systematic reviewJournal of Epidemiology and Community Health, 55
R. Fontijn, B. Goud, A. Echard, F. Jollivet, J. Marle, H. Pannekoek, A. Horrevoets (2001)
The Human Kinesin-Like Protein RB6K Is under Tight Cell Cycle Control and Is Essential for CytokinesisMolecular and Cellular Biology, 21
H. Lijnen, D. Collen (1999)
Matrix Metalloproteinase System Deficiencies and Matrix DegradationThrombosis and Haemostasis, 82
B. Eskenazi, L. Rosas, A. Marks, A. Bradman, K. Harley, N. Holland, Caroline Johnson, L. Fenster, D. Barr (2008)
Pesticide toxicity and the developing brain.Basic & clinical pharmacology & toxicology, 102 2
Oussema Souiai, F. Guerfali, Slimane Miled, C. Brun, Alia Benkahla (2001)
In silico prediction of protein-protein interactions in human macrophagesBMC Research Notes, 7
T Watanabe I Okazaki (2000)
Molecular mechanism of the reversibility of hepatic fibrosis: with special reference to the role of matrix metalloproteinasesJ. Gastroenterol. Hepatol., 15
B. Herrera, M. Murillo, A. Alvarez-Barrientos, J. Beltrán, Margarita Fernández, I. Fabregat (2004)
Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-beta in fetal rat hepatocytes.Free radical biology & medicine, 36 1
A. Gribenko, James Hopper, G. Makhatadze (2001)
Molecular characterization and tissue distribution of a novel member of the S100 family of EF-hand proteins.Biochemistry, 40 51
A. Fanidi, E. Harrington, G. Evan (1992)
Cooperative interaction between c-myc and bcl-2 proto-oncogenesNature, 359
M. Iida, H. Iwata, H. Inoue, M. Enomoto, N. Horie, K. Takeishi (2000)
Correlation between Bcl-2 overexpression and H-ras mutation in naturally occurring hepatocellular proliferative lesions of the B6C3F1 mouse.Toxicological sciences : an official journal of the Society of Toxicology, 56 2
M. Berg, L. Birnbaum, M. Denison, Michael Vito, W. Farland, M. Feeley, H. Fiedler, H. Håkansson, A. Hanberg, L. Haws, M. Rose, S. Safe, D. Schrenk, C. Tohyama, A. Tritscher, J. Tuomisto, M. Tysklind, N. Walker, R. Peterson (2006)
The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds.Toxicological sciences : an official journal of the Society of Toxicology, 93 2
J. Namieśnik, B. Zabiegała, Á. Kot-Wasik, M. Partyka, A. Wasik (2005)
Passive sampling and/or extraction techniques in environmental analysis: a reviewAnalytical and Bioanalytical Chemistry, 381
W. Bursch, M. Chabicovsky, U. Wastl, B. Grasl-Kraupp, K. Bukowska, H. Taper, R. Schulte‐Hermann (2005)
Apoptosis in stages of mouse hepatocarcinogenesis: failure to counterbalance cell proliferation and to account for strain differences in tumor susceptibility.Toxicological sciences : an official journal of the Society of Toxicology, 85 1
Mi-Kyung Song, Mee Song, Han-Seam Choi, J. Ryu (2012)
Benzo[k]fluoranthene-induced changes in miRNA-mRNA interactions in human hepatocytesToxicology and Environmental Health Sciences, 4
Jinan Li, A. Ny, G. Leonardsson, Kutty Nandakumar, R. Holmdahl, T. Ny (2005)
The plasminogen activator/plasmin system is essential for development of the joint inflammatory phase of collagen type II-induced arthritis.The American journal of pathology, 166 3
M. Hansen, F. Matsumura (2001)
Effects of heptachlor epoxide on components of various signal transduction pathways important in tumor promotion in mouse hepatoma cells. Determination of the most sensitive tumor promoter related effect induced by heptachlor epoxide.Toxicology, 160 1-3
S. Dickerson, A. Gore (2007)
Estrogenic environmental endocrine-disrupting chemical effects on reproductive neuroendocrine function and dysfunction across the life cycleReviews in Endocrine and Metabolic Disorders, 8
E. Webster, D. Mackay, F. Wania (1998)
Evaluating environmental persistenceEnvironmental Toxicology and Chemistry, 17
I. Okazaki, Tetsu Watanabe, S. Hozawa, M. Arai, K. Maruyama (2000)
HEPATOLOGY: MICROCIRCULATION AND PATHOGENESIS OF ALCOHOLIC LIVER INJURY Molecular mechanism of the reversibility of hepatic fibrosis: With special reference to the role of matrix metalloproteinases
C. Jager, P. Farías, A. Barraza‐Villarreal, M. Ávila, P. Ayotte, É. Dewailly, C. Dombrowski, F. Rousseau, Vicente Sánchez, J. Bailey (2006)
Reduced seminal parameters associated with environmental DDT exposure and p,p'-DDE concentrations in men in Chiapas, Mexico: a cross-sectional study.Journal of andrology, 27 1
T. Aasen, M. Hodgins, M. Edward, S. Graham (2003)
The relationship between connexins, gap junctions, tissue architecture and tumour invasion, as studied in a novel in vitro model of HPV-16-associated cervical cancer progressionOncogene, 22
R. Yao, D. Davidson, A. López-Beltran, G. MacLennan, R. Montironi, L. Cheng (2007)
The S100 proteins for screening and prognostic grading of bladder cancer.Histology and histopathology, 22 9
S. Heymans, A. Luttun, D. Nuyens, G. Theilmeier, E. Creemers, L. Moons, G. Dyspersin, J. Cleutjens, M. Shipley, A. Angellilo, M. Levi, O. Nüβe, A. Baker, E. Keshet, F. Lupu, J. Herbert, J. Smits, S. Shapiro, M. Baes, M. Borgers, D. Collen, M. Daemen, P. Carmeliet (1999)
Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failureNature Medicine, 5
Yoshio Takeda, H. Togashi, H. Shinzawa, S. Miyano, Rika Ishii, Tetsuru Karasawa, Yumiko Takeda, Takafumi Saito, Koji Saito, Hiroko Haga, T. Matsuo, M. Aoki, H. Mitsuhashi, Hisayoshi Watanabe, Tsuneo Takahashi (2000)
Spontaneous regression of hepatocellular carcinoma and review of literatureJournal of Gastroenterology and Hepatology, 15
M. Sakaguchi, M. Miyazaki, T. Kondo, M. Namba (2001)
Up-regulation of S100C in normal human fibroblasts in the process of aging in vitroExperimental Gerontology, 36
M. Fischer, M. Ma, S. Goerg, X Zhou, J. Xia, O. Finco, S. Han, G. Kelsoe, R. Howard, T. Rothstein, E. Kremmer, F. Rosen, M. Carroll (1996)
Regulation of the B cell response to T-dependent antigens by classical pathway complement.Journal of immunology, 157 2
G. Daston, E. Faustman, G. Ginsberg, P. Fenner-Crisp, S. Olin, B. Sonawane, J. Bruckner, W. Breslin, T. McLaughlin (2004)
A framework for assessing risks to children from exposure to environmental agents.Environmental Health Perspectives, 112
Dan Luo, S. Cheng, Hong Xie, Yong Xie (2000)
Effects of Bcl-2 and Bcl-XL protein levels on chemoresistance of hepatoblastoma HepG2 cell line.Biochemistry and cell biology = Biochimie et biologie cellulaire, 78 2
S. Snedeker (2001)
Pesticides and breast cancer risk: a review of DDT, DDE, and dieldrin.Environmental Health Perspectives, 109
Hongming Zhou, I. Bolon, A. Nichols, A. Wohlwend, J. Vassalli (2001)
Overexpression of plasminogen activator inhibitor type 2 in basal keratinocytes enhances papilloma formation in transgenic mice.Cancer research, 61 3
E. Hill, Mairi Clarke, F. Barr (2000)
The Rab6‐binding kinesin, Rab6‐KIFL, is required for cytokinesisThe EMBO Journal, 19
M. Aardema, J. Macgregor (2002)
Toxicology and genetic toxicology in the new era of "toxicogenomics": impact of "-omics" technologies.Mutation research, 499 1
N. Julen, H. Dauchel, C. Lemercier, Robert Sim, M. Fontaine, J. Ripoche (1992)
In vitro biosynthesis of complement factor I by human endothelial cellsEuropean Journal of Immunology, 22
R Tibshirani VG Tusher (2001)
Significance analysis of microarrays applied to the ionizing radiation responseProc. Natl. Acad. Sci. USA, 98
Abstract Persistent organic pollutants (POPs) are a major group of contaminants. They are geographically widely distributed, circulate globally, and remain intact in the environment for a long period. POPs accumulate particularly in the fatty tissue of living organisms. Although many chemicals are suspected to have hazardous effects, evaluation of their toxicities remains difficult and challenging. In this study, we used toxicogenomic tools that are simple and economical, as compared to other tools of risk assessment. To predict the risk of environmental toxic substances or compounds, investigation of toxicological mechanisms or biomarkers is important. In this study, we identified hepatotoxicity-related genes induced by three POPs (chlordane, toxaphene, and mirex) in the human hepatocellular carcinoma (HepG2) cell line using microarray and gene ontology (GO) analyses. Using microarray analyses, we identified genes that were up- and down-regulated by greater than 1.5-fold. After the GO analyses, we determined several key pathways that are known to be related to hepatotoxicity, including the metabolism of xenobiotics by apoptosis, complement and coagulation cascades, and cell cycle regulation. Thus, our present study suggests that differentially expressed genes by POPs may provide clues for the hepatotoxic mechanism of POPs. In addition, gene expression profiling by toxicogenomic analyses also affords promising opportunities to reveal new toxicity mechanistic markers.
BioChip Journal – Springer Journals
Published: Mar 1, 2013
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