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Curr Allergy Asthma Rep (2017) 17: 6 DOI 10.1007/s11882-017-0674-5 ALLERGENS (RK BUSH AND JA WOODFOLK, SECTION EDITORS) The Skin as a Route of Allergen Exposure: Part I. Immune Components and Mechanisms 1 2,3 1 1,4 Anna R. Smith & George Knaysi & Jeffrey M. Wilson & Julia A. Wisniewski Published online: 9 February 2017 Springer Science+Business Media New York 2017 Abstract phoid cells (ILC2s), mast cells (MCs), and basophils have Purpose of Review To highlight recent contributions in the been shown to promote AD and pathogenic Th2 responses literature that enhance our understanding of the cutaneous in murine models. immune response to allergen. Summary Skin barrier disruption favors induction of systemic Th2-associated inflammatory pathways. A better understand- Recent Findings Defects in skin barrier function in infancy set ing of the ontogeny and regulation of these complex networks the stage for the development of atopic dermatitis (AD) and in infant skin is needed to guide future strategies for allergy allergy. Both genetic and environmental factors can contribute treatment and prevention. to damage of the stratum corneum (SC), with activation of specific protease enzymes under high pH conditions playing . . Keywords Atopic dermatitis Epicutaneous allergy a key role. Immune cells
Current Allergy and Asthma Reports – Springer Journals
Published: Feb 9, 2017
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