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ISSN 0003-6838, Applied Biochemistry and Microbiology, 2019, Vol. 55, No. 6, pp. 639–648. © Pleiades Publishing, Inc., 2019. Russian Text © The Author(s), 2019, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2019, Vol. 55, No. 6, pp. 542–552. The Role of LaeA and LovE Regulators in Lovastatin Biosynthesis with Exogenous Polyamines in Aspergillus terreus a, a a A. A. Zhgun *, G. K. Nuraeva , and M. A. Eldarov Institute of Bioengineering, Fundamentals of Biotechnology Federal Research Center, Russian Academy of Sciences, Moscow, 119071 Russia *e-mail: Zzhgun@mail.ru Received February 27, 2019; revised May 16, 2019; accepted June 20, 2019 Abstract—The f ilamentous fungus Aspergillus terreus is the main industrial producer of a cholesterol-lowering drug, lovastatin, and simvastatin obtained on its basis. The biosynthesis of lovastatin in A. terreus is under the control of two major positive regulators, the LovE pathway-specific regulator and LaeA global regulator of the secondary metabolism of fungi. It is shown that laeA expression can be negatively regulated by LovE, the Zn Cys transcription factor of lovastatin biosynthesis. The overexpression of lovE under the control of the 2 6 gpdA constitutive promoter from Aspergillus nidulans, which results in a 10- to 30-fold increase in lovastatin production is
Applied Biochemistry and Microbiology – Springer Journals
Published: Dec 6, 2019
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