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The Role of Angiogenesis in Neuroblastoma

The Role of Angiogenesis in Neuroblastoma Neuroblastoma (NB), a common pediatric neoplasm arising from neural crest cells, is characterized by a diversity of clinical behavior ranging from spontaneous remission to rapid tumor progression and death. Biologic and genetic factors have been identified which, to a certain extent, can predict prognosis and guide risk-based therapy. Recent research has focused on the role of angiogenesis in NB tumor biology and in determining clinical phenotype. Preclinical studies have explored the efficacy of antiangiogenic therapies as a novel treatment modality for children with NB. This review discusses the current understanding of angiogenesis in NB, the clinical implications, and future directions for antiangiogenic therapeutic strategies in NB. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Cancer Springer Journals

The Role of Angiogenesis in Neuroblastoma

American Journal of Cancer , Volume 2 (4) – Aug 10, 2012

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Publisher
Springer Journals
Copyright
Copyright © 2003 by Adis Data Information BV
Subject
Pharmacy; Pharmacy
ISSN
1175-6357
DOI
10.2165/00024669-200302040-00002
Publisher site
See Article on Publisher Site

Abstract

Neuroblastoma (NB), a common pediatric neoplasm arising from neural crest cells, is characterized by a diversity of clinical behavior ranging from spontaneous remission to rapid tumor progression and death. Biologic and genetic factors have been identified which, to a certain extent, can predict prognosis and guide risk-based therapy. Recent research has focused on the role of angiogenesis in NB tumor biology and in determining clinical phenotype. Preclinical studies have explored the efficacy of antiangiogenic therapies as a novel treatment modality for children with NB. This review discusses the current understanding of angiogenesis in NB, the clinical implications, and future directions for antiangiogenic therapeutic strategies in NB.

Journal

American Journal of CancerSpringer Journals

Published: Aug 10, 2012

References