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The Residual Center of Mass: An Image Descriptor for the Diagnosis of Alzheimer Disease

The Residual Center of Mass: An Image Descriptor for the Diagnosis of Alzheimer Disease A crucial quest in neuroimaging is the discovery of image features (biomarkers) associated with neurodegenerative disorders. Recent works show that such biomarkers can be obtained by image analysis techniques. However, these techniques cannot be directly compared since they use different databases and validation protocols. In this paper, we present an extensive study of image descriptors for the diagnosis of Alzheimer Disease (AD) and introduce a new one, named Residual Center of Mass (RCM). The RCM descriptor explores image moments and other techniques to enhance brain regions and select discriminative features for the diagnosis of AD. For validation, a Support Vector Machine (SVM) is trained with the selected features to classify images from normal subjects and patients with AD. We show that RCM with SVM achieves the best accuracies on a considerable number of exams by 10-fold cross-validation — 95.1% on 507 FDG-PET scans and 90.3% on 1374 MRI scans. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroinformatics Springer Journals

The Residual Center of Mass: An Image Descriptor for the Diagnosis of Alzheimer Disease

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References (47)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Neurosciences; Bioinformatics; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Neurology
ISSN
1539-2791
eISSN
1559-0089
DOI
10.1007/s12021-018-9390-0
Publisher site
See Article on Publisher Site

Abstract

A crucial quest in neuroimaging is the discovery of image features (biomarkers) associated with neurodegenerative disorders. Recent works show that such biomarkers can be obtained by image analysis techniques. However, these techniques cannot be directly compared since they use different databases and validation protocols. In this paper, we present an extensive study of image descriptors for the diagnosis of Alzheimer Disease (AD) and introduce a new one, named Residual Center of Mass (RCM). The RCM descriptor explores image moments and other techniques to enhance brain regions and select discriminative features for the diagnosis of AD. For validation, a Support Vector Machine (SVM) is trained with the selected features to classify images from normal subjects and patients with AD. We show that RCM with SVM achieves the best accuracies on a considerable number of exams by 10-fold cross-validation — 95.1% on 507 FDG-PET scans and 90.3% on 1374 MRI scans.

Journal

Neuroinformatics – Springer Journals

Published: Oct 17, 2018

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