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The Reactivity of 3-Hydroxy-6-methyl-2-ethylpyridine 2-Nitroxysuccinate and Reference Drugs in Model NO-Generating Systems

The Reactivity of 3-Hydroxy-6-methyl-2-ethylpyridine 2-Nitroxysuccinate and Reference Drugs in... ISSN 0012-5008, Doklady Chemistry, 2019, Vol. 486, Part 2, pp. 152–155. © Pleiades Publishing, Ltd., 2019. Russian Text © The Author(s), 2019, published in Doklady Akademii Nauk, 2019, Vol. 486, No. 4. CHEMISTRY The Reactivity of 3-Hydroxy-6-methyl-2-ethylpyridine 2-Nitroxysuccinate and Reference Drugs in Model NO-Generating Systems a, b a a a† a,c O. V. Pokidova *, E. V. Batova , A. P. Sadkov , A. B. Eremeev , B. S. Fedorov , and A. I. Kotelnikov Presented by Academician S.M. Aldoshin January 14, 2019 Received February 13, 2019 Abstract—The ability of 3-hydroxy-6-methyl-2-ethylpyridine 2-nitroxysuccinate (I) to generate nitrite ions (NO ) and nitrogen monoxide (NO) in model systems with cysteine (Cys) and deoxyhemoglobin (Hb) has been studied. Compound I has been found to release NO and NO more efficiently than Nicorandil. The accumulation rate of in the system of Cys with I is by a factor of 1.5 higher than that with Nitroglycerin. NO It has been shown that, in contrast to Nitroglycerin, compound I is not reduced by Hb. DOI: 10.1134/S0012500819060016 compound also behaves as a good inhibitor of phos- At present time, an important task of public health phodiesterase [6], an enzyme, which, along with gua- is to decrease http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Doklady Chemistry Springer Journals

The Reactivity of 3-Hydroxy-6-methyl-2-ethylpyridine 2-Nitroxysuccinate and Reference Drugs in Model NO-Generating Systems

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References (11)

Publisher
Springer Journals
Copyright
Copyright © 2019 by Pleiades Publishing, Ltd.
Subject
Chemistry; Chemistry/Food Science, general; Industrial Chemistry/Chemical Engineering
ISSN
0012-5008
eISSN
1608-3113
DOI
10.1134/S0012500819060016
Publisher site
See Article on Publisher Site

Abstract

ISSN 0012-5008, Doklady Chemistry, 2019, Vol. 486, Part 2, pp. 152–155. © Pleiades Publishing, Ltd., 2019. Russian Text © The Author(s), 2019, published in Doklady Akademii Nauk, 2019, Vol. 486, No. 4. CHEMISTRY The Reactivity of 3-Hydroxy-6-methyl-2-ethylpyridine 2-Nitroxysuccinate and Reference Drugs in Model NO-Generating Systems a, b a a a† a,c O. V. Pokidova *, E. V. Batova , A. P. Sadkov , A. B. Eremeev , B. S. Fedorov , and A. I. Kotelnikov Presented by Academician S.M. Aldoshin January 14, 2019 Received February 13, 2019 Abstract—The ability of 3-hydroxy-6-methyl-2-ethylpyridine 2-nitroxysuccinate (I) to generate nitrite ions (NO ) and nitrogen monoxide (NO) in model systems with cysteine (Cys) and deoxyhemoglobin (Hb) has been studied. Compound I has been found to release NO and NO more efficiently than Nicorandil. The accumulation rate of in the system of Cys with I is by a factor of 1.5 higher than that with Nitroglycerin. NO It has been shown that, in contrast to Nitroglycerin, compound I is not reduced by Hb. DOI: 10.1134/S0012500819060016 compound also behaves as a good inhibitor of phos- At present time, an important task of public health phodiesterase [6], an enzyme, which, along with gua- is to decrease

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Doklady Chemistry – Springer Journals

Published: Aug 5, 2019

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