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References (73)
-
S. Lajoie, I. Lewkowich, Yusuke Suzuki, J. Clark, A. Sproles, K. Dienger, A. Budelsky, M. Wills-Karp (2010)
Complement-mediated regulation of the interleukin 17A axis is a central genetic determinant of the severity of experimental allergic asthmaNature immunology, 11
-
T. Moseley, Dominik Haudenschild, L. Rose, A. Reddi (2003)
Interleukin-17 family and IL-17 receptors.Cytokine & growth factor reviews, 14 2
-
A. Maitra, F. Shen, W. Hanel, K. Mossman, J. Tocker, David Swart, S. Gaffen (2007)
Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expressionProceedings of the National Academy of Sciences, 104
-
S. Nakae, Yutaka Komiyama, Aya Nambu, K. Sudo, M. Iwase, I. Homma, K. Sekikawa, M. Asano, Y. Iwakura (2002)
Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses.Immunity, 17 3
-
Z. Yao, S. Painter, W. Fanslow, D. Ulrich, B. Macduff, M. Spriggs, R. Armitage (1995)
Human IL-17: a novel cytokine derived from T cells.Journal of immunology, 155 12
-
M. Epstein (2006)
Targeting memory Th2 cells for the treatment of allergic asthma.Pharmacology & therapeutics, 109 1-2
-
Hanzhong Li, Jian Chen, A. Huang, Jeremy Stinson, Sherry Heldens, J. Foster, P. Dowd, A. Gurney, W. Wood (2000)
Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family.Proceedings of the National Academy of Sciences of the United States of America, 97 2
-
F Spinozzi, E Agea, O Bistoni (1996)
Increased allergen-specific, steroid-sensitive gamma delta T cells in bronchoalveolar lavage fluid from patients with asthmaAnn Intern Med, 124
-
James Lee, W. Ho, M. Maruoka, Racquel Corpuz, Daryl Baldwin, J. Foster, A. Goddard, D. Yansura, R. Vandlen, W. Wood, A. Gurney (2001)
IL-17E, a Novel Proinflammatory Ligand for the IL-17 Receptor Homolog IL-17Rh1*The Journal of Biological Chemistry, 276
-
G. Anderson (2008)
Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous diseaseThe Lancet, 372
-
Eva Acosta-Rodriguez, G. Napolitani, A. Lanzavecchia, F. Sallusto (2007)
Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cellsNature Immunology, 8
-
Xuexian Yang, B. Pappu, R. Nurieva, A. Akimzhanov, Hong Kang, Yeonseok Chung, Li Ma, Bhavin Shah, Athanasia Panopoulos, K. Schluns, S. Watowich, Qiang Tian, A. Jetten, C. Dong (2008)
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma.Immunity, 28 1
-
Zhengbin Yao, Eugene Maraskovsky, M. Spriggs, J. Cohen, R. Armitage, M. Alderson (1996)
Herpesvirus saimiri open reading frame 14, a protein encoded by T lymphotropic herpesvirus, binds to MHC class II molecules and stimulates T cell proliferation.Journal of immunology, 156 9
-
Trevor Starnes, M. Robertson, G. Sledge, S. Kelich, H. Nakshatri, H. Broxmeyer, R. Hromas (2001)
Cutting Edge: IL-17F, a Novel Cytokine Selectively Expressed in Activated T Cells and Monocytes, Regulates Angiogenesis and Endothelial Cell Cytokine Production1The Journal of Immunology, 167
-
Paul Mangan, L. Harrington, Darrell O'Quinn, Whitney Helms, D. Bullard, C. Elson, R. Hatton, S. Wahl, T. Schoeb, C. Weaver (2006)
Transforming growth factor-beta induces development of the T(H)17 lineage.Nature, 441 7090
-
H. Wakashin, K. Hirose, Y. Maezawa, S. Kagami, A. Suto, N. Watanabe, Y. Saito, M. Hatano, T. Tokuhisa, Y. Iwakura, P. Puccetti, I. Iwamoto, H. Nakajima (2008)
IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice.American journal of respiratory and critical care medicine, 178 10
-
Jill Wright, Frann Bennett, Bilian Li, J. Brooks, D. Luxenberg, M. Whitters, K. Tomkinson, L. Fitz, N. Wolfman, M. Collins, K. Dunussi-joannopoulos, M. Chatterjee‐Kishore, B. Carreno (2008)
The Human IL-17F/IL-17A Heterodimeric Cytokine Signals through the IL-17RA/IL-17RC Receptor ComplexThe Journal of Immunology, 181
-
J. Chakir, J. Shannon, S. Molet, M. Fukakusa, J. Elias, M. Laviolette, L. Boulet, Q. Hamid (2003)
Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression.The Journal of allergy and clinical immunology, 111 6
-
P. Ye, F. Rodriguez, S. Kanaly, K. Stocking, J. Schurr, P. Schwarzenberger, P. Oliver, Weitao Huang, Ping Zhang, Jason Zhang, J. Shellito, G. Bagby, S. Nelson, K. Charrier, J. Peschon, J. Kolls (2001)
Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host DefenseThe Journal of Experimental Medicine, 194
-
S. Schnyder‐Candrian, D. Togbe, I. Couillin, I. Mercier, F. Brombacher, V. Quesniaux, F. Fossiez, B. Ryffel, B. Schnyder (2006)
Interleukin-17 is a negative regulator of established allergic asthmaThe Journal of Experimental Medicine, 203
-
A. Barczyk, W. Pierzchała, E. Sozańska (2003)
Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine.Respiratory medicine, 97 6
-
Jean-Marc Doisne, V. Soulard, C. Bécourt, L. Amniai, P. Henrot, C. Havenar-Daughton, C. Blanchet, L. Zitvogel, B. Ryffel, J. Cavaillon, J. Marie, I. Couillin, K. Benlagha (2011)
Cutting Edge: Crucial Role of IL-1 and IL-23 in the Innate IL-17 Response of Peripheral Lymph Node NK1.1− Invariant NKT Cells to BacteriaThe Journal of Immunology, 186
-
W. Leonard, R. Zeng, R. Spolski (2008)
Interleukin 21: a cytokine/cytokine receptor system that has come of ageJournal of Leukocyte Biology, 84
-
I. Ivanov, Brent McKenzie, Liang Zhou, C. Tadokoro, A. Lepelley, J. Lafaille, D. Cua, D. Littman (2006)
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper CellsCell, 126
-
S. Molet, Q. Hamid, Francis Davoineb, E. Nutku, Rame Tahaa, N. Pagé, R. Olivenstein, J. Elias, J. Chakir (2001)
IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines.The Journal of allergy and clinical immunology, 108 3
-
Yu Wang, K. Voo, Bo Liu, Chun-Yu Chen, Burcin Uygungil, W. Spoede, J. Bernstein, D. Huston, Yong‐jun Liu (2010)
A novel subset of CD4+ TH2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthmaThe Journal of Experimental Medicine, 207
-
M. Laan, Zhan-Qun Cui, H. Hoshino, J. Lötvall, M. Sjöstrand, D. Gruenert, B. Skoogh, A. Lindén (1999)
Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways.Journal of immunology, 162 4
-
ML Michel, AC Keller, C Paget (2007)
Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophiliaJ Exp Med, 204
-
Rhonda Wilson, G. Whitehead, H. Nakano, M. Free, J. Kolls, D. Cook (2009)
Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness.American journal of respiratory and critical care medicine, 180 8
-
Frangois Fossiez, O. Djossou, Pascale Chornarat, L. Flores-Romo, S. Ait-Yahia, C. Maat, J. Pin, P. Garrone, Eric García, S. Saeland, D. Blanchard, Claude Gaillard, B. Mahapatra, Eric Rouvierfl, Pierre Golsteinfl, J. Banchereau, S. Lebecque (1996)
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokinesThe Journal of Experimental Medicine, 183
-
Jill Wright, Yongjing Guo, A. Quazi, D. Luxenberg, Frann Bennett, J. Ross, Y. Qiu, M. Whitters, K. Tomkinson, K. Dunussi-joannopoulos, B. Carreno, M. Collins, N. Wolfman (2007)
Identification of an Interleukin 17F/17A Heterodimer in Activated Human CD4+ T Cells*Journal of Biological Chemistry, 282
-
J. Renauld (2001)
New insights into the role of cytokines in asthmaJournal of Clinical Pathology, 54
-
O. Akbari, P. Stock, E. Meyer, M. Kronenberg, S. Sidobre, T. Nakayama, M. Taniguchi, M. Grusby, R. DeKruyff, D. Umetsu (2003)
Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivityNature Medicine, 9
-
E. Bettelli, Yijun Carrier, Wenda Gao, T. Korn, T. Strom, M. Oukka, H. Weiner, V. Kuchroo (2006)
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsNature, 441
-
Carol Jones, Katie Chan (2002)
Interleukin-17 stimulates the expression of interleukin-8, growth-related oncogene-alpha, and granulocyte-colony-stimulating factor by human airway epithelial cells.American journal of respiratory cell and molecular biology, 26 6
-
F. Polack, M. Teng, Peter L.Collins, G. Prince, M. Exner, H. Regele, Dario Lirman, R. Rabold, S. Hoffman, C. Karp, S. Kleeberger, M. Wills-Karp, R. Karron (2002)
A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus DiseaseThe Journal of Experimental Medicine, 196
-
Xun Zhang, I. Lewkowich, Gabriele Köhl, J. Clark, M. Wills-Karp, J. Köhl (2009)
A Protective Role for C5a in the Development of Allergic Asthma Associated with Altered Levels of B7-H1 and B7-DC on Plasmacytoid Dendritic Cells 1The Journal of Immunology, 182
-
C. Karp, A. Grupe, E. Schadt, S. Ewart, Michelle Keane-Moore, P. Cuomo, J. Köhl, L. Wahl, D. Kuperman, S. Germer, D. Aud, G. Peltz, M. Wills-Karp (2000)
Identification of complement factor 5 as a susceptibility locus for experimental allergic asthmaNature Immunology, 1
-
R Nakamura, K Shibata, H Yamada, K Shimoda, K Nakayama, Y Yoshikai (2008)
Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cellsJ Immunol, 181
-
C. Nembrini, B. Marsland, M. Kopf (2009)
IL-17-producing T cells in lung immunity and inflammation.The Journal of allergy and clinical immunology, 123 5
-
P. Matangkasombut, G. Marigowda, A. Ervine, L. Idris, M. Pichavant, Hye Kim, T. Yasumi, S. Wilson, R. DeKruyff, J. Faul, E. Israel, O. Akbari, D. Umetsu (2009)
Natural killer T cells in the lungs of patients with asthma.The Journal of allergy and clinical immunology, 123 5
-
Li Yang, David Anderson, C. Baecher-Allan, W. Hastings, E. Bettelli, M. Oukka, V. Kuchroo, D. Hafler (2008)
IL-21 and TGF-β are required for differentiation of human TH17 cellsNature, 454
-
M. McGeachy, Yi Chen, C. Tato, A. Laurence, B. Joyce-Shaikh, W. Blumenschein, T. Mcclanahan, J. O’Shea, D. Cua (2009)
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivoNature Immunology, 10
-
J. Milner, J. Brenchley, A. Laurence, A. Freeman, Brenna Hill, K. Elias, Y. Kanno, C. Spalding, H. Elloumi, Michelle Paulson, Joie Davis, A. Hsu, A. Asher, J. O’Shea, S. Holland, W. Paul, D. Douek (2008)
Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndromeNature, 452
-
J. Simpson, R. Scott, M. Boyle, P. Gibson (2006)
Inflammatory subtypes in asthma: Assessment and identification using induced sputumRespirology, 11
-
M. Wills-Karp (1999)
Immunologic basis of antigen-induced airway hyperresponsiveness.Annual review of immunology, 17
-
C. Dinarello (2011)
Blocking interleukin‐1β in acute and chronic autoinflammatory diseasesJournal of Internal Medicine, 269
-
Dror Luger, P. Silver, Jun Tang, D. Cua, Zoe Chen, Y. Iwakura, E. Bowman, Nicole Sgambellone, C. Chan, R. Caspi (2008)
Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector categoryThe Journal of Experimental Medicine, 205
-
N. Manel, D. Unutmaz, D. Littman (2008)
The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγtNature Immunology, 9
-
Wisam Al-Ramli, D. Préfontaine, F. Chouiali, James Martin, R. Olivenstein, C. Lemière, Q. Hamid (2009)
T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma.The Journal of allergy and clinical immunology, 123 5
-
F. Spinozzi, E. Agea, O. Bistoni, N. Forenza, A. Monaco, G. Bassotti, I. Nicoletti, C. Riccardi, F. Grignani, A. Bertotto (1996)
Increased Allergen-Specific, Steroid-Sensitive T Cells in Bronchoalveolar Lavage Fluid from Patients with AsthmaAnnals of Internal Medicine, 124
-
R. Nakamura, K. Shibata, H. Yamada, K. Shimoda, K. Nakayama, Y. Yoshikai (2008)
Tyk2-Signaling Plays an Important Role in Host Defense against Escherichia coli through IL-23-Induced IL-17 Production by γδ T Cells1The Journal of Immunology, 181
-
M. Veldhoen, R. Hocking, C. Atkins, R. Locksley, B. Stockinger (2006)
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.Immunity, 24 2
-
S. Chang, C. Dong (2007)
A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responsesCell Research, 17
-
Liang Zhou, I. Ivanov, R. Spolski, Roy Min, K. Shenderov, Takeshi Egawa, D. Levy, W. Leonard, D. Littman (2007)
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathwaysNature Immunology, 8
-
D. Jovanovic, J. Battista, J. Martel-Pelletier, F. Jolicoeur, Yulan He, Mengkun Zhang, F. Mineau, J. Pelletier (1998)
IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages.Journal of immunology, 160 7
-
Heon Park, Zhaoxia Li, Xuexian Yang, S. Chang, R. Nurieva, Yi-hong Wang, Ying Wang, L. Hood, Zhou Zhu, Qiang Tian, C. Dong (2005)
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Nature Immunology, 6
-
C. Murphy, C. Langrish, Yi Chen, W. Blumenschein, T. Mcclanahan, R. Kastelein, J. Sedgwick, D. Cua (2003)
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune InflammationThe Journal of Experimental Medicine, 198
-
A. Hastie, W. Moore, D. Meyers, Penny Vestal, Huashi Li, S. Peters, E. Bleecker (2010)
Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes.The Journal of allergy and clinical immunology, 125 5
-
Youcun Qian, Caini Liu, J. Hartupee, C. Altuntas, M. Gulen, Dan Jane-wit, Jianhua Xiao, Yi Lu, N. Giltiay, Jinbo Liu, T. Kordula, Qiwei Zhang, B. Vallance, S. Swaidani, M. Aronica, V. Tuohy, T. Hamilton, Xiaoxia Li (2007)
The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory diseaseNature Immunology, 8
-
S. Gaffen (2009)
Structure and signalling in the IL-17 receptor familyNature Reviews Immunology, 9
-
L. Mckinley, J. Alcorn, Alanna Peterson, Rachel Dupont, S. Kapadia, A. Logar, Adam Henry, C. Irvin, J. Piganelli, A. Ray, J. Kolls (2008)
TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice1The Journal of Immunology, 181
-
N. Wilson, K. Boniface, J. Chan, Brent McKenzie, W. Blumenschein, J. Mattson, B. Basham, Kathleen Smith, Taiying Chen, F. Morel, J. Lecron, R. Kastelein, D. Cua, T. Mcclanahan, E. Bowman, R. Malefyt (2007)
Development, cytokine profile and function of human interleukin 17–producing helper T cellsNature Immunology, 8
-
S. Hymowitz, E. Filvaroff, Jianping Yin, James Lee, L. Cai, P. Risser, M. Maruoka, W. Mao, J. Foster, R. Kelley, Guohua Pan, A. Gurney, A. Vos, M. Starovasnik (2001)
IL‐17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL‐17F, and implications for receptor bindingThe EMBO Journal, 20
-
Xuexian Yang, Athanasia Panopoulos, R. Nurieva, S. Chang, Demin Wang, S. Watowich, C. Dong (2007)
STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells*Journal of Biological Chemistry, 282
-
C. Lloyd, E. Hessel (2010)
Functions of T cells in asthma: more than just TH2 cellsNature Reviews Immunology, 10
-
C. Reynolds, J. Barkans, P. Clark, H. Kariyawasam, D. Altmann, B. Kay, R. Boyton (2009)
Natural killer T cells in bronchial biopsies from human allergen challenge model of allergic asthma.The Journal of allergy and clinical immunology, 124 4
-
L. Harrington, Paul Mangan, C. Weaver (2006)
Expanding the effector CD4 T-cell repertoire: the Th17 lineage.Current opinion in immunology, 18 3
-
L. Romani, F. Fallarino, A. Luca, C. Montagnoli, C. D’Angelo, T. Zelante, C. Vacca, F. Bistoni, M. Fioretti, U. Grohmann, B. Segal, P. Puccetti (2008)
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous diseaseNature, 451
-
E. Bettelli, T. Korn, M. Oukka, V. Kuchroo (2008)
Induction and effector functions of TH17 cellsNature, 453
-
Marie‐Laure Michel, A. Keller, C. Paget, M. Fujio, F. Trottein, P. Savage, Chi‐Huey Wong, E. Schneider, M. Dy, M. Leite-de-Moraes
Brief Definitive Report Identifi Cation of an Il-17–producing Nk1.1 Neg Inkt Cell Population Involved in Airway Neutrophilia -
M. McGeachy, D. Cua (2007)
The link between IL-23 and Th17 cell-mediated immune pathologies.Seminars in immunology, 19 6
-
D. Cua, J. Sherlock, Yi Chen, C. Murphy, Barbara Joyce, B. Seymour, L. Lucian, W. To, Sylvia Kwan, T. Churakova, S. Zurawski, M. Wiekowski, S. Lira, D. Gorman, R. Kastelein, J. Sedgwick (2003)
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainNature, 421
- Publisher
- Springer Journals
- Copyright
- Copyright © 2011 by Springer Science+Business Media, LLC
- Subject
- Medicine & Public Health; Allergology
- ISSN
- 1529-7322
- eISSN
- 1534-6315
- DOI
- 10.1007/s11882-011-0210-y
- pmid
- 21773747
- Publisher site
- See Article on Publisher Site
Abstract
Asthma has long been characterized as a disease of dysregulated T-helper type 2 immune responses to environmental allergens. Clinical studies suggest that asthma is a heterogeneous disorder with distinct types of inflammatory processes. Accumulating evidence suggests that aberrant interleukin (IL)-17 production is a key determinant of severe forms of asthma. However, the identity of IL-17–producing cells and the factors regulating IL-17 production during the course of allergic inflammation remain elusive. In this review, we summarize the potential IL-17–producing cells and their involvement in the inflammatory responses that mediate distinct features of asthma. The role of proinflammatory cytokines and the complement pathway in regulating the generation of IL-17–producing T cells is also discussed. Understanding the biology of IL-17 in the context of allergic inflammation may be informative in the development of novel approaches to the diagnosis and treatment of asthma.
Journal
Current Allergy and Asthma Reports – Springer Journals
Published: Jul 20, 2011