Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

The post-anaphylaxis dilemma: How long is long enough to observe a patient after resolution of symptoms?

The post-anaphylaxis dilemma: How long is long enough to observe a patient after resolution of... Anaphylaxis may recur 1 to 72 hours after initial signs and symptoms apparently resolve. Reported incidence of biphasic anaphylaxis varies from 1% to 23%. Late-phase severity varies from mild to severe (rarely fatal). No evidence or expert consensus presently identifies distinguishing characteristics in the initial phase that predict a late phase. However, reports propose potential risk factors, including initial phase severity, delayed or suboptimal doses of epinephrine during initial treatment, laryngeal edema or hypotension during initial phase, delayed symptomatic onset after antigen exposure, or history of biphasic anaphylaxis. It is unclear whether systemic corticosteroids administered in the initial phase can prevent or weaken late-phase reactions. Based on available evidence, observation periods after complete resolution of uniphasic anaphylaxis should be individualized, particularly because there are no reliable predictors of biphasic anaphylaxis. A 10-hour observation period appears sufficient, but some investigators recommend 24 hours. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Allergy and Asthma Reports Springer Journals

The post-anaphylaxis dilemma: How long is long enough to observe a patient after resolution of symptoms?

Current Allergy and Asthma Reports , Volume 8 (1) – Jan 30, 2008

Loading next page...
 
/lp/springer-journals/the-post-anaphylaxis-dilemma-how-long-is-long-enough-to-observe-a-m67Qm1IiOB

References (27)

Publisher
Springer Journals
Copyright
Copyright © 2008 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Otorhinolaryngology; Pneumology/Respiratory System; Allergology
ISSN
1529-7322
eISSN
1534-6315
DOI
10.1007/s11882-008-0009-7
Publisher site
See Article on Publisher Site

Abstract

Anaphylaxis may recur 1 to 72 hours after initial signs and symptoms apparently resolve. Reported incidence of biphasic anaphylaxis varies from 1% to 23%. Late-phase severity varies from mild to severe (rarely fatal). No evidence or expert consensus presently identifies distinguishing characteristics in the initial phase that predict a late phase. However, reports propose potential risk factors, including initial phase severity, delayed or suboptimal doses of epinephrine during initial treatment, laryngeal edema or hypotension during initial phase, delayed symptomatic onset after antigen exposure, or history of biphasic anaphylaxis. It is unclear whether systemic corticosteroids administered in the initial phase can prevent or weaken late-phase reactions. Based on available evidence, observation periods after complete resolution of uniphasic anaphylaxis should be individualized, particularly because there are no reliable predictors of biphasic anaphylaxis. A 10-hour observation period appears sufficient, but some investigators recommend 24 hours.

Journal

Current Allergy and Asthma ReportsSpringer Journals

Published: Jan 30, 2008

There are no references for this article.