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The influence of medium composition on alkaloid biosynthesis by Penicillium citrinum

The influence of medium composition on alkaloid biosynthesis by Penicillium citrinum The fungus P. citrinum produces secondary metabolites, clavinet ergot alkaloids (EA), and quinoline alkaloids (quinocitrinines, QA) in medium with various carbon and nitrogen sources and in the presence of iron, copper, and zinc additives. Mannitol and sucrose are most favorable for EA biosynthesis and mannitol is most favorable for QA. Maximum alkaloid production is observed on urea. Iron and copper additives in the medium containing zinc ions stimulated fungal growth but inhibited alkaloid biosynthesis. The production of these secondary metabolites does not depend on the physiological state of culture, probably due to the constitutive nature of the enzymes involved in biosynthesis of these substances. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Biochemistry and Microbiology Springer Journals

The influence of medium composition on alkaloid biosynthesis by Penicillium citrinum

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References (1)

Publisher
Springer Journals
Copyright
Copyright © 2010 by Pleiades Publishing, Ltd.
Subject
Life Sciences; Medical Microbiology ; Microbiology ; Biochemistry, general
ISSN
0003-6838
eISSN
1608-3024
DOI
10.1134/S0003683810050108
Publisher site
See Article on Publisher Site

Abstract

The fungus P. citrinum produces secondary metabolites, clavinet ergot alkaloids (EA), and quinoline alkaloids (quinocitrinines, QA) in medium with various carbon and nitrogen sources and in the presence of iron, copper, and zinc additives. Mannitol and sucrose are most favorable for EA biosynthesis and mannitol is most favorable for QA. Maximum alkaloid production is observed on urea. Iron and copper additives in the medium containing zinc ions stimulated fungal growth but inhibited alkaloid biosynthesis. The production of these secondary metabolites does not depend on the physiological state of culture, probably due to the constitutive nature of the enzymes involved in biosynthesis of these substances.

Journal

Applied Biochemistry and Microbiology – Springer Journals

Published: Sep 11, 2010

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