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The Influence of Gender and Age on Upper Airway Reflexes

The Influence of Gender and Age on Upper Airway Reflexes Purpose of Review Differences in upper airway collapsibility are thought to underlie the observations that obstructive sleep apnea (OSA) is more common in men and in older individuals. Baseline neuromuscular activity and upper airway reflexes are two of the determinants of upper airway size and collapsibility and gender and aging differences in these determinants could explain, in part, differences in OSA prevalence. The purpose of this review is to review the influence of gender and age on upper airway reflexes. Recent Findings Most recent findings indicate that aging is associated with both changes in baseline neuromuscular activity of the genioglossus muscle (when studied as muscle unit potentials) and is associated with impairment in upper airway reflexes, particularly the perception response to inspiratory loading. Summary The limited data on gender differences in upper airway reflexes shows no difference in the negative pressure reflex or relationship between epiglottic pressure and genioglossus activity. Thus, gender differences in upper airway collapsibility are probably not explained by differences in upper airway reflexes. In contrast, there is evidence that upper airway reflexes are impaired with aging and these impairments might contribute to the increased collapsibility of the upper airway observed in some, though not all, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Sleep Medicine Reports Springer Journals

The Influence of Gender and Age on Upper Airway Reflexes

Rowley, James
Current Sleep Medicine Reports , Volume 4 (4) – Oct 6, 2018
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References (40)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Nature Switzerland AG
Subject
Medicine & Public Health; Internal Medicine; General Practice / Family Medicine; Otorhinolaryngology; Neurology; Cardiology; Psychiatry
eISSN
2198-6401
DOI
10.1007/s40675-018-0128-1
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Differences in upper airway collapsibility are thought to underlie the observations that obstructive sleep apnea (OSA) is more common in men and in older individuals. Baseline neuromuscular activity and upper airway reflexes are two of the determinants of upper airway size and collapsibility and gender and aging differences in these determinants could explain, in part, differences in OSA prevalence. The purpose of this review is to review the influence of gender and age on upper airway reflexes. Recent Findings Most recent findings indicate that aging is associated with both changes in baseline neuromuscular activity of the genioglossus muscle (when studied as muscle unit potentials) and is associated with impairment in upper airway reflexes, particularly the perception response to inspiratory loading. Summary The limited data on gender differences in upper airway reflexes shows no difference in the negative pressure reflex or relationship between epiglottic pressure and genioglossus activity. Thus, gender differences in upper airway collapsibility are probably not explained by differences in upper airway reflexes. In contrast, there is evidence that upper airway reflexes are impaired with aging and these impairments might contribute to the increased collapsibility of the upper airway observed in some, though not all,

Journal

Current Sleep Medicine Reports – Springer Journals

Published: Oct 6, 2018

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