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The Impact of Immunodeficiency on NK Cell Maturation and Function

The Impact of Immunodeficiency on NK Cell Maturation and Function Purpose of Review Natural killer cells are innate lymphoid cells (ILCs) that play critical roles in human host defense and are especially useful in combating viral pathogens and malignancy. Recent Findings The NK cell deficiency (NKD) is particularly underscored in patients with a congenital immunodefi- ciency in which NK cell development or function is affected. The classical NK cell deficiency (cNKD) is a result of absent or a profound decrease in the number of circulating NK cells. In contrast, functional NKD (fNKD) is charac- terized by abnormal NK cell function but with normal number of NK cells. The combined immune deficiencies with significant impact on NK cells are not considered classical or functional NK cell deficiencies. In these disorders, the impairment of NK cells represents an important aspect of the overall immunodeficiency. In turn, this leads to improved insights on the NK cell development and function. Summary Here, we detail the NK cell biology based upon recent natural killer cell defects described in combined immune deficiencies. Keywords Natural killer cells NK cell deficiency Introduction and severe viral infections. It is a deficiency in NK cell number, less than 1% of circulating lymphocytes, ac- In humans, the importance of NK http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Allergy and Asthma Reports Springer Journals

The Impact of Immunodeficiency on NK Cell Maturation and Function

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References (82)

Publisher
Springer Journals
Copyright
Copyright © 2019 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Allergology
ISSN
1529-7322
eISSN
1534-6315
DOI
10.1007/s11882-019-0836-8
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Natural killer cells are innate lymphoid cells (ILCs) that play critical roles in human host defense and are especially useful in combating viral pathogens and malignancy. Recent Findings The NK cell deficiency (NKD) is particularly underscored in patients with a congenital immunodefi- ciency in which NK cell development or function is affected. The classical NK cell deficiency (cNKD) is a result of absent or a profound decrease in the number of circulating NK cells. In contrast, functional NKD (fNKD) is charac- terized by abnormal NK cell function but with normal number of NK cells. The combined immune deficiencies with significant impact on NK cells are not considered classical or functional NK cell deficiencies. In these disorders, the impairment of NK cells represents an important aspect of the overall immunodeficiency. In turn, this leads to improved insights on the NK cell development and function. Summary Here, we detail the NK cell biology based upon recent natural killer cell defects described in combined immune deficiencies. Keywords Natural killer cells NK cell deficiency Introduction and severe viral infections. It is a deficiency in NK cell number, less than 1% of circulating lymphocytes, ac- In humans, the importance of NK

Journal

Current Allergy and Asthma Reports – Springer Journals

Published: Jan 19, 2019

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