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- Publisher
- Springer Journals
- Copyright
- Copyright © 2005 by Current Science Inc
- Subject
- Medicine & Public Health; Allergology; Pneumology/Respiratory System; Otorhinolaryngology; Infectious Diseases
- ISSN
- 1529-7322
- eISSN
- 1534-6315
- DOI
- 10.1007/s11882-005-0037-5
- Publisher site
- See Article on Publisher Site
Abstract
The interaction of immunoglobulin E (IgE) and its receptors is critical for the manifestation of allergic disease. Currently, IgE receptors include the high-affinity FcεRI and the lowaffinity FcεRII. FcεRI is a tetrameric or trimeric complex, and each has distinct expression patterns and unique functional consequences. In general, serum levels of IgE regulate FcεRI expression, and novel therapies that lower the concentration of IgE have provided insights into the contribution of this receptor in allergic disease. Newer therapies targeting FcεRI-signaling elements and the lowaffinity IgE receptor, FcεRII (CD23), are being developed.
Journal
Current Allergy and Asthma Reports – Springer Journals
Published: May 27, 2005