Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/the-immune-microenvironment-of-human-tumors-general-significance-and-bPRnaTF9ts
References (65)
-
F. Pagès, A. Berger, M. Camus, F. Sánchez-Cabo, A. Costes, Robert Molidor, B. Mlecnik, A. Kirilovsky, M. Nilsson, D. Damotte, T. Méatchi, P. Bruneval, P. Cugnenc, Z. Trajanoski, W. Fridman, J. Galon (2005)
Effector memory T cells, early metastasis, and survival in colorectal cancer.The New England journal of medicine, 353 25
-
R. Schreiber, L. Old, M. Smyth (2011)
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and PromotionScience, 331
-
E. Tartour, F. Fossiez, I. Joyeux, A. Galinha, A. Gey, E. Claret, X. Sastre-Garau, J. Couturier, V. Mosseri, V. Vives, J. Banchereau, W. Fridman, J. Wijdenes, S. Lebecque, Catherine Sautèes-Fridman (1999)
Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice.Cancer research, 59 15
-
J. Galon, W. Fridman, F. Pagès (2007)
The adaptive immunologic microenvironment in colorectal cancer: a novel perspective.Cancer research, 67 5
-
S. Birkeland, H. Storm, L. Lamm, L. Barlow, I. Blohmé, B. Forsberg, B. Eklund, O. Fjeldborg, Michael Friedberg, L. Frödin, E. Glattre, S. Halvorsen, N. Holm, A. Jakobsen, H. Jorgensen, J. Ladefoged, T. Lindholm, G. Lundgren, E. Pukkala (1995)
Cancer risk after renal transplantation in the nordic countries, 1964–1986International Journal of Cancer, 60
-
E. Mamessier, A. Sylvain, Marie‐Laure Thibult, G. Houvenaeghel, J. Jacquemier, R. Castellano, A. Gonçalves, P. André, F. Romagné, G. Thibault, P. Viens, D. Birnbaum, F. Bertucci, A. Moretta, D. Olive (2011)
Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity.The Journal of clinical investigation, 121 9
-
H. Long, G. Taylor, A. Rickinson (2011)
Immune defence against EBV and EBV-associated disease.Current opinion in immunology, 23 2
-
J. Moyron-Quiroz, J. Rangel-Moreno, Louise Hartson, Kim Kusser, Michael Tighe, K. Klonowski, L. Lefrançois, L. Cauley, A. Harmsen, F. Lund, T. Randall (2006)
Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organs.Immunity, 25 4
-
J. Wilmott, G. Long, J. Howle, L. Haydu, Raghwa Sharma, J. Thompson, R. Kefford, P. Hersey, R. Scolyer (2011)
Selective BRAF Inhibitors Induce Marked T-cell Infiltration into Human Metastatic MelanomaClinical Cancer Research, 18
-
B. Mlecnik, M. Tosolini, P. Charoentong, A. Kirilovsky, G. Bindea, A. Berger, M. Camus, M. Gillard, P. Bruneval, W. Fridman, F. Pagès, Z. Trajanoski, J. Galon (2010)
Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer.Gastroenterology, 138 4
-
O. Nakano, Makoto Sato, Y. Naito, Kensho Suzuki, S. Orikasa, M. Aizawa, Yasuyoshi Suzuki, Ichirou Shintaku, H. Nagura, H. Ohtani (2001)
Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity.Cancer research, 61 13
-
Zhihai Qin, G. Richter, T. Schüler, Sabrina Ibe, Xuetao Cao, T. Blankenstein (1998)
B cells inhibit induction of T cell-dependent tumor immunityNature Medicine, 4
-
Neĭman Im (1974)
[Inflammation and cancer].Patologicheskaia fiziologiia i eksperimental'naia terapiia, 0 4
-
J. Galon, F. Pagès, F. Marincola, M. Thurin, G. Trinchieri, B. Fox, T. Gajewski, P. Ascierto (2012)
The immune score as a new possible approach for the classification of cancerJournal of Translational Medicine, 10
-
O. Adotévi, H. Péré, P. Ravel, N. Haicheur, C. Badoual, N. Merillon, J. Medioni, S. Peyrard, S. Roncelin, V. Verkarre, A. Méjean, W. Fridman, S. Oudard, E. Tartour (2010)
A Decrease of Regulatory T Cells Correlates With Overall Survival After Sunitinib-based Antiangiogenic Therapy in Metastatic Renal Cancer PatientsJournal of Immunotherapy, 33
-
J. Jass (1986)
Lymphocytic infiltration and survival in rectal cancer.Journal of Clinical Pathology, 39
-
T. Nomi, M. Sho, T. Akahori, K. Hamada, A. Kubo, H. Kanehiro, Shinji Nakamura, K. Enomoto, H. Yagita, M. Azuma, Y. Nakajima (2007)
Clinical Significance and Therapeutic Potential of the Programmed Death-1 Ligand/Programmed Death-1 Pathway in Human Pancreatic CancerClinical Cancer Research, 13
-
J. Brahmer, S. Tykodi, L. Chow, W. Hwu, S. Topalian, P. Hwu, C. Drake, L. Camacho, J. Kauh, K. Odunsi, H. Pitot, O. Hamid, S. Bhatia, R. Martins, K. Eaton, Shuming Chen, Theresa Salay, S. Alaparthy, J. Grosso, A. Korman, S. Parker, S. Agrawal, S. Goldberg, D. Pardoll, A. Gupta, J. Wigginton (2012)
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.The New England journal of medicine, 366 26
-
F. Pagès, J. Galon, J. Galon, J. Galon, M. Dieu-Nosjean, M. Dieu-Nosjean, M. Dieu-Nosjean, E. Tartour, C. Sautès-Fridman, C. Sautès-Fridman, C. Sautès-Fridman, W. Fridman (2010)
Immune infiltration in human tumors: a prognostic factor that should not be ignoredOncogene, 29
-
D. Carragher, J. Rangel-Moreno, T. Randall (2008)
Ectopic lymphoid tissues and local immunity.Seminars in immunology, 20 1
-
N. Halama, S. Michel, M. Kloor, I. Zoernig, A. Benner, Anna Spille, T. Pommerencke, D. Knebel, G. Folprecht, B. Luber, Nadine Feyen, U. Martens, P. Beckhove, S. Gnjatic, P. Schirmacher, E. Herpel, J. Weitz, N. Grabe, D. Jaeger (2011)
Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy.Cancer research, 71 17
-
C. Sautès-Fridman, Julien Cherfils-Vicini, D. Damotte, S. Fisson, W. Fridman, I. Cremer, M. Dieu-Nosjean (2011)
Tumor microenvironment is multifacetedCancer and Metastasis Reviews, 30
-
F Pagès, A Kirilovsky, B Mlecnik, M Asslaber, M Tosolini, G Bindea, C Lagorce, P Wind, P Bruneval, K Zatloukal, Z Trajanoski, A Berger, WH Fridman, J Galon (2009)
In situ cytotoxic and memory T cells predict outcome in early-stage colorectal cancer patientsJ Clin Oncol, 27
-
M. Noman, Y. Messai, Thibault Carré, Intissar Akalay, Marine Méron, B. Janji, M. Hasmim, S. Chouaib (2011)
Microenvironmental hypoxia orchestrating the cell stroma cross talk, tumor progression and antitumor response.Critical reviews in immunology, 31 5
-
P. Simsa, J. Teillaud, D. Stott, J. Tóth, B. Kotlán (2008)
Tumor-infiltrating B cell immunoglobulin variable region gene usage in invasive ductal breast carcinomaPathology & Oncology Research, 11
-
Pauline Andreu, M. Johansson, Nesrine Affara, F. Pucci, T. Tan, S. Junankar, Lidiya Korets, J. Lam, D. Tawfik, D. DeNardo, L. Naldini, K. Visser, Michele Palma, L. Coussens (2010)
FcRgamma activation regulates inflammation-associated squamous carcinogenesis.Cancer cell, 17 2
-
A. Nardin, Wing-Cheong Wong, C. Tow, T. Molina, F. Tissier, Anne Audebourg, M. Garcette, A. Caignard, M. Avril, J. Abastado, A. Prévost-Blondel (2011)
Dacarbazine promotes stromal remodeling and lymphocyte infiltration in cutaneous melanoma lesions.The Journal of investigative dermatology, 131 9
-
E. Tartour, A. Gey, W. Fridman, X. Sastre-Garau, Isabelle Surin, V. Mosseri (1998)
Prognostic value of intratumoral interferon gamma messenger RNA expression in invasive cervical carcinomas.Journal of the National Cancer Institute, 90 4
-
Q. Gao, S. Qiu, Jia Fan, Jian Zhou, Xiao-Ying Wang, Yong-sheng Xiao, Yang Xu, Yi-wei Li, Zhao-You Tang (2007)
Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 25 18
-
J. Yang, Leah Haworth, R. Sherry, P. Hwu, D. Schwartzentruber, S. Topalian, S. Steinberg, Helen Chen, S. Rosenberg (2003)
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer.The New England journal of medicine, 349 5
-
B. Mlecnik, M. Tosolini, A. Kirilovsky, A. Berger, G. Bindea, T. Méatchi, P. Bruneval, Z. Trajanoski, W. Fridman, F. Pagès, J. Galon (2011)
Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29 6
-
L Thomas (1982)
On immunosurveillance in human cancerYale J Biol, 55
-
J. Galon, A. Costes, F. Sánchez-Cabo, A. Kirilovsky, B. Mlecnik, C. Lagorce-Pagès, M. Tosolini, M. Camus, A. Berger, P. Wind, F. Zinzindohoué, P. Bruneval, P. Cugnenc, Z. Trajanoski, W. Fridman, F. Pagès (2006)
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical OutcomeScience, 313
-
I. Mellman, G. Coukos, G. Dranoff (2011)
Cancer immunotherapy comes of ageNature, 480
-
Zhihai Qin, T. Blankenstein (2004)
A cancer immunosurveillance controversyNature Immunology, 5
-
F. Hodi, S. O'Day, D. McDermott, R. Weber, J. Sosman, J. Haanen, R. Gonzalez, C. Robert, D. Schadendorf, Jessica Hassel, W. Akerley, A. Eertwegh, J. Lutzky, P. Lorigan, Julia Vaubel, G. Linette, D. Hogg, C. Ottensmeier, C. Lebbé, C. Peschel, I. Quirt, Joseph Clark, J. Wolchok, J. Weber, Jason Tian, M. Yellin, G. Nichol, A. Hoos, W. Urba (2010)
Improved survival with ipilimumab in patients with metastatic melanoma.The New England journal of medicine, 363 8
-
M. Tosolini, A. Kirilovsky, B. Mlecnik, T. Fredriksen, S. Mauger, G. Bindea, A. Berger, P. Bruneval, W. Fridman, F. Pagès, J. Galon (2011)
Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer.Cancer research, 71 4
-
R. Menegaz, M. Michelin, R. Etchebehere, P. Fernandes, E. Murta (2008)
Peri- and intratumoral T and B lymphocytic infiltration in breast cancer.European journal of gynaecological oncology, 29 4
-
Ludovic Martinet, I. Garrido, T. Filleron, S. Guellec, E. Bellard, J. Fournié, P. Rochaix, J. Girard (2011)
Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer.Cancer research, 71 17
-
M. Burnet (1964)
IMMUNOLOGICAL FACTORS IN THE PROCESS OF CARCINOGENESIS.British medical bulletin, 20
-
G. Dunn, L. Old, R. Schreiber (2004)
The three Es of cancer immunoediting.Annual review of immunology, 22
-
F. Pagès, A. Kirilovsky, B. Mlecnik, M. Asslaber, M. Tosolini, G. Bindea, C. Lagorce, P. Wind, F. Marliot, P. Bruneval, K. Zatloukal, Z. Trajanoski, A. Berger, W. Fridman, J. Galon (2009)
In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 27 35
-
Catherine Koebel, W. Vermi, J. Swann, N. Zerafa, S. Rodig, L. Old, M. Smyth, R. Schreiber (2007)
Adaptive immunity maintains occult cancer in an equilibrium stateNature, 450
-
W. Fridman, J. Teillaud, C. Sautès-Fridman, F. Pagès, J. Galon, J. Zucman‐Rossi, E. Tartour, L. Zitvogel, G. Kroemer (2011)
The Ultimate Goal of Curative Anti-Cancer Therapies: Inducing an Adaptive Anti-Tumor Immune ResponseFrontiers in Immunology, 2
-
L. Chaisemartin, J. Goc, D. Damotte, P. Validire, P. Magdeleinat, M. Alifano, I. Cremer, W. Fridman, C. Sautès-Fridman, M. Dieu-Nosjean (2011)
Characterization of chemokines and adhesion molecules associated with T cell presence in tertiary lymphoid structures in human lung cancer.Cancer research, 71 20
-
S. Topalian, F. Hodi, J. Brahmer, S. Gettinger, David Smith, David McDermott, J. Powderly, Richard Carvajal, J. Sosman, M. Atkins, P. Leming, D. Spigel, S. Antonia, L. Horn, Charles Drake, D. Pardoll, Lieping Chen, W. Sharfman, Robert Anders, J. Taube, T. McMiller, Haiying Xu, A. Korman, M. Jure-Kunkel, S. Agrawal, D. McDonald, G. Kollia, A. Gupta, J. Wigginton, M. Sznol (2012)
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.The New England journal of medicine, 366 26
-
L. Zitvogel, O. Kepp, G. Kroemer (2011)
Immune parameters affecting the efficacy of chemotherapeutic regimensNature Reviews Clinical Oncology, 8
-
F. Donskov, H. Maase (2006)
Impact of immune parameters on long-term survival in metastatic renal cell carcinoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24 13
-
B. Kotlán, P. Simsa, J. Teillaud, W. Fridman, J. Tóth, M. McKnight, M. Glassy (2005)
Novel Ganglioside Antigen Identified by B Cells in Human Medullary Breast Carcinomas: The Proof of Principle Concerning the Tumor-Infiltrating B Lymphocytes1The Journal of Immunology, 175
-
Samuel Kim, Z. Fridlender, R. Dunn, M. Kehry, V. Kapoor, A. Blouin, L. Kaiser, S. Albelda (2008)
B-cell Depletion Using an Anti-CD20 Antibody Augments Antitumor Immune Responses and Immunotherapy in Nonhematopoetic Murine Tumor ModelsJournal of Immunotherapy, 31
-
K. Visser, Lidiya Korets, L. Coussens (2005)
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent.Cancer cell, 7 5
-
S. Katz, V. Pillarisetty, Zubin Bamboat, J. Shia, C. Hedvat, M. Gonen, W. Jarnagin, Y. Fong, L. Blumgart, M. D'Angelica, R. DeMatteo (2009)
T Cell Infiltrate Predicts Long-Term Survival Following Resection of Colorectal Cancer Liver MetastasesAnnals of Surgical Oncology, 16
-
J. Moyron-Quiroz, J. Rangel-Moreno, Kim Kusser, Louise Hartson, F. Sprague, S. Goodrich, D. Woodland, F. Lund, T. Randall (2004)
Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunityNature Medicine, 10
-
W. Fridman, F. Pagès, C. Sautès-Fridman, J. Galon (2012)
The immune contexture in human tumours: impact on clinical outcomeNature Reviews Cancer, 12
-
D. Pardoll (2012)
The blockade of immune checkpoints in cancer immunotherapyNature Reviews Cancer, 12
-
W. Fridman, B. Mlecnik, G. Bindea, F. Pagès, J. Galon (2011)
Immunosurveillance in human non-viral cancers.Current opinion in immunology, 23 2
-
N. Leffers, M. Gooden, R. Jong, B. Hoogeboom, K. Hoor, H. Hollema, H. Boezen, A. Zee, T. Daemen, H. Nijman (2009)
Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancerCancer Immunology, Immunotherapy, 58
-
S. Platonova, Julien Cherfils-Vicini, D. Damotte, L. Crozet, V. Vieillard, P. Validire, P. André, M. Dieu-Nosjean, M. Alifano, J. Régnard, W. Fridman, C. Sautès-Fridman, I. Cremer (2011)
Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma.Cancer research, 71 16
-
A. Mantovani, P. Allavena, A. Sica, F. Balkwill (2008)
Cancer-related inflammationNature, 454
-
J. Rosenblatt, B. Glotzbecker, Heidi Mills, B. Vasir, D. Tzachanis, J. Levine, R. Joyce, Kerry Wellenstein, Whitney Keefe, M. Schickler, R. Rotem‐Yehudar, D. Kufe, D. Avigan (2011)
PD-1 Blockade by CT-011, Anti-PD-1 Antibody, Enhances Ex Vivo T-cell Responses to Autologous Dendritic Cell/Myeloma Fusion VaccineJournal of Immunotherapy, 34
-
M. Dieu-Nosjean, M. Antoine, C. Danel, D. Heudes, M. Wislez, V. Poulot, N. Rabbe, L. Laurans, E. Tartour, L. Chaisemartin, S. Lebecque, W. Fridman, J. Cadranel (2008)
Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 26 27
-
Lin Zhang, J. Conejo-Garcia, D. Katsaros, P. Gimotty, M. Massobrio, G. Regnani, A. Makrigiannakis, H. Gray, K. Schlienger, M. Liebman, S. Rubin, G. Coukos (2003)
Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.The New England journal of medicine, 348 3
-
L. Coussens, Z. Werb (2002)
Inflammation and cancerNature, 420
-
R. MacKie, R. Reid, B. Junor (2003)
Fatal melanoma transferred in a donated kidney 16 years after melanoma surgery.The New England journal of medicine, 348 6
-
D. Hanahan, R. Weinberg (2011)
Hallmarks of Cancer: The Next GenerationCell, 144
- Publisher
- Springer Journals
- Copyright
- Copyright © 2012 by Springer Science+Business Media Dordrecht
- Subject
- Biomedicine; Cancer Research; Oncology; Immunology; Cell Biology; Biochemistry, general; Biomedicine general
- ISSN
- 1875-2292
- eISSN
- 1875-2284
- DOI
- 10.1007/s12307-012-0124-9
- pmid
- 23108700
- Publisher site
- See Article on Publisher Site
Abstract
Human cancers grow in a microenvironment of stromal, inflammatory and immunocompetent cells which is variable from tumor to tumor. The characterization of the immune contexture, i.e. the type, density and functional orientation of immunocompetent cells, the presence or absence of tertiary lymphoid structures is a major prognostic factor for patients survival and represent a guide and a target for innovative cancer therapies.
Journal
Cancer Microenvironment – Springer Journals
Published: Oct 30, 2012