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The haematology ofTrypanosoma congolense infection in cattle I. Sequential cytomorphological changes in the blood and bone marrow of Boran cattle

The haematology ofTrypanosoma congolense infection in cattle I. Sequential cytomorphological... Five adult Boran cattle (Bos indicus), infected with a clone ofTrypanosoma congolense IL13-E3 three years earlier and treated, were re-challenged with the same clone. Changes in the peripheral blood were monitored twice weekly, and events in the bone marrow (BM) were assessed by weekly biopsies of the sternal BM, until day 98 postinfection (dpi) when the three surviving animals were treated with diminazene aceturate. One animal died on 57 dpi whereas another was treated on 63 dpi when the packed cell volume was 15%. The infected animals developed anaemia, leucopenia and thrombocytopenia during the first peak of parasitaemia which persisted until the experiment was terminated. Three phases of BM response were demonstrated on light microscopic examination of BM smears. The first, the preparasitaemic phase represented by samples taken on 15 dpi, was an immunological response with slight but significant increases in lymphoblasts, lymphocytes, plasma cells and macrophages (Mø) whereas erythroid and granulocytic cells were unchanged. The second, the early parasitaemic or acute phase (21–57 dpi) associated with the development of anaemia, leucopenia and thrombocytopenia, was characterised by intensification of the immunological response, and an early but transient granulocytic hyperplasia. The third, the late parasitaemic or chronic phase (63–98 dpi) associated with persisting pancytopenia, was characterised by erythroid, megakaryocytic and Mø hyperplasia, dyserythropoiesis, granulocyte hypoplasia and return of lymphoid cell counts to preinfection numbers. Transmission electron microscopy confirmed these findings and showed that intact trypanosomes were not observed in the sinusoids and haemopoiesic compartment of the BM. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

The haematology ofTrypanosoma congolense infection in cattle I. Sequential cytomorphological changes in the blood and bone marrow of Boran cattle

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References (43)

Publisher
Springer Journals
Copyright
Copyright © 1997 by Springer-Verlag London Limited
Subject
Medicine & Public Health; Hematology; Oncology
eISSN
1433-2973
DOI
10.1007/BF01320994
Publisher site
See Article on Publisher Site

Abstract

Five adult Boran cattle (Bos indicus), infected with a clone ofTrypanosoma congolense IL13-E3 three years earlier and treated, were re-challenged with the same clone. Changes in the peripheral blood were monitored twice weekly, and events in the bone marrow (BM) were assessed by weekly biopsies of the sternal BM, until day 98 postinfection (dpi) when the three surviving animals were treated with diminazene aceturate. One animal died on 57 dpi whereas another was treated on 63 dpi when the packed cell volume was 15%. The infected animals developed anaemia, leucopenia and thrombocytopenia during the first peak of parasitaemia which persisted until the experiment was terminated. Three phases of BM response were demonstrated on light microscopic examination of BM smears. The first, the preparasitaemic phase represented by samples taken on 15 dpi, was an immunological response with slight but significant increases in lymphoblasts, lymphocytes, plasma cells and macrophages (Mø) whereas erythroid and granulocytic cells were unchanged. The second, the early parasitaemic or acute phase (21–57 dpi) associated with the development of anaemia, leucopenia and thrombocytopenia, was characterised by intensification of the immunological response, and an early but transient granulocytic hyperplasia. The third, the late parasitaemic or chronic phase (63–98 dpi) associated with persisting pancytopenia, was characterised by erythroid, megakaryocytic and Mø hyperplasia, dyserythropoiesis, granulocyte hypoplasia and return of lymphoid cell counts to preinfection numbers. Transmission electron microscopy confirmed these findings and showed that intact trypanosomes were not observed in the sinusoids and haemopoiesic compartment of the BM.

Journal

Comparative Clinical PathologySpringer Journals

Published: Dec 7, 2004

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