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The effects of Fumaria officinalis hydroalcoholic extracts on haematological profile of New Zealand rabbits

The effects of Fumaria officinalis hydroalcoholic extracts on haematological profile of New... Plants and plant extracts are used extensively to treat many diseases. Fumaria officinalis is an annual plant from the genus Fumaria which has long been used in herbal medicine. The aim of this study was to examine the haematological effects of F. officinalis hydroalcoholic extract in rabbits. This study was conducted over a period of 28 days. Two doses of F. officinalis hydroalcoholic extract (200 and 400 mg/kg body weight) were administrated orally to two groups of rabbits. Parameters evaluated included packed cell volume (PCV), Hb, mean corpuscular volume (MCV), RBC and total and differential WBC count. The results showed that F. officinalis hydroalcoholic extract (FOHE) produces a non-dose-dependent significant (P < 0.05) decrease in PCV, Hb, MCV, RBC, total WBC and neutrophil percentage in the two experimental groups when compared with the control group. However, it increased lymphocyte, eosinophil and monocyte percentages. In conclusion, FOHE reduces haematological activity in rabbits which should warrant its consideration in the management of anaemia and immunity-dependent disorders. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

The effects of Fumaria officinalis hydroalcoholic extracts on haematological profile of New Zealand rabbits

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References (34)

Publisher
Springer Journals
Copyright
Copyright © 2013 by Springer-Verlag London
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1618-565X
DOI
10.1007/s00580-013-1705-9
Publisher site
See Article on Publisher Site

Abstract

Plants and plant extracts are used extensively to treat many diseases. Fumaria officinalis is an annual plant from the genus Fumaria which has long been used in herbal medicine. The aim of this study was to examine the haematological effects of F. officinalis hydroalcoholic extract in rabbits. This study was conducted over a period of 28 days. Two doses of F. officinalis hydroalcoholic extract (200 and 400 mg/kg body weight) were administrated orally to two groups of rabbits. Parameters evaluated included packed cell volume (PCV), Hb, mean corpuscular volume (MCV), RBC and total and differential WBC count. The results showed that F. officinalis hydroalcoholic extract (FOHE) produces a non-dose-dependent significant (P < 0.05) decrease in PCV, Hb, MCV, RBC, total WBC and neutrophil percentage in the two experimental groups when compared with the control group. However, it increased lymphocyte, eosinophil and monocyte percentages. In conclusion, FOHE reduces haematological activity in rabbits which should warrant its consideration in the management of anaemia and immunity-dependent disorders.

Journal

Comparative Clinical PathologySpringer Journals

Published: Mar 2, 2013

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