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- Publisher
- Springer Journals
- Copyright
- Copyright © 2012 by Korean Society of Nuclear Medicine
- Subject
- Medicine & Public Health; Cardiology; Imaging / Radiology; Oncology; Nuclear Medicine; Orthopedics
- ISSN
- 1869-3474
- eISSN
- 1869-3482
- DOI
- 10.1007/s13139-012-0158-4
- pmid
- 24900070
- Publisher site
- See Article on Publisher Site
Abstract
Nucl Med Mol Imaging (2012) 46:239–246 DOI 10.1007/s13139-012-0158-4 ORIGINAL ARTICLE The Effect of Tanespimycin (17-AAG) on Radioiodine Accumulation in Sodium-Iodide Symporter Expressing Cells Kyoung Hyun Yu & Hyewon Youn & Myung Geun Song & Dong Soo Lee & June-Key Chung Received: 17 September 2011 /Revised: 4 May 2012 /Accepted: 15 July 2012 /Published online: 15 August 2012 # Korean Society of Nuclear Medicine 2012 Abstract levels of NIS mRNA after tanespimycin treatment was an Purpose The heat shock protein 90 inhibitor, tanespimycin, is observed increase in the hNIS-ARO cells. an anticancer agent known to increase iodine accumulation in Conclusions These results indicate that cellular responses normal and cancerous thyroid cells. Iodine accumulation is against tanespimycin treatment differed between the normal regulated by membrane proteins such as sodium iodide sym- rat thyroid cells and human cancer cells, and the reduction in porter (NIS) and pendrin (PDS), and thus we attempted to the I efflux rate by tanespimycin in the normal rat thyroid characterize the effects of tanespimycin on those genes. cells might be attributable to reduced PDS gene expression. Methods Cells were incubated with tanespimycin in order to . . evaluate I accumulation and efflux ability. Radioiodine Keywords Thyroid cancer
Journal
Nuclear Medicine and Molecular Imaging – Springer Journals
Published: Aug 15, 2012