Access the full text.
Sign up today, get DeepDyve free for 14 days.
N. Hammoudi, Dongtak Jeong, Rajvir Singh, Ahmed Farhat, M. Komajda, E. Mayoux, R. Hajjar, D. Lebeche (2017)
Empagliflozin Improves Left Ventricular Diastolic Dysfunction in a Genetic Model of Type 2 DiabetesCardiovascular Drugs and Therapy, 31
J. Westerbacka, H. Yki-Järvinen, A. Turpeinen, A. Rissanen, S. Vehkavaara, M. Syrjälä, R. Lassila (2002)
Inhibition of Platelet‐Collagen Interaction An In Vivo Action of Insulin Abolished by Insulin Resistance in ObesityArteriosclerosis, Thrombosis, and Vascular Biology, 22
(2013)
Sodium-glucose co-transporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysisAnn Intern Med, 159
N. Seecheran, A. Maharaj, Brent Boodhai, R. Seecheran, Valmiki Seecheran, S. Persad, K. Ramsaroop, S. Sandy, S. Giddings, S. Sakhamuri, R. Ali, Mohanchan Motilal, S. Teelucksingh, A. Tello-Montoliu (2019)
Prevalence of clOpidogrel ‘resIstaNce’ in a selected population of patients undergoing elective percutaneous coronary intervention at a tertiary cardiovascular centre in Trinidad: the POINT pilot studyOpen Heart, 6
Hoong Lim, A. Blann, G. Lip (2004)
Soluble CD40 Ligand, Soluble P-Selectin, Interleukin-6, and Tissue Factor in Diabetes Mellitus: Relationships to Cardiovascular Disease and Risk Factor InterventionCirculation: Journal of the American Heart Association, 109
H. Storgaard, Lise Gluud, Cathy Bennett, Magnus Grøndahl, M. Christensen, Filip Knop, Tina Vilsbøll (2016)
Benefits and Harms of Sodium-Glucose Co-Transporter 2 Inhibitors in Patients with Type 2 Diabetes: A Systematic Review and Meta-AnalysisPLoS ONE, 11
B. Bonora, A. Avogaro, G. Fadini (2020)
Extraglycemic Effects of SGLT2 Inhibitors: A Review of the EvidenceDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 13
Liang Xu, N. Nagata, M. Nagashimada, F. Zhuge, Y. Ni, Guanliang Chen, E. Mayoux, S. Kaneko, Tsuguhito Ota (2017)
SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese MiceEBioMedicine, 20
M. Yngen, A. Norhammar, P. Hjemdahl, N. Wallén (2006)
Effects of improved metabolic control on platelet reactivity in patients with type 2 diabetes mellitus following coronary angioplastyDiabetes & Vascular Disease Research, 3
P. Winocour, C. Watała, Raelene Kinglough-Rathbone (1992)
Membrane Fluidity Is Related to the Extent of Glycation of Proteins, but not to Alterations in the Cholesterol to Phospholipid Molar Ratio in Isolated Platelet Membranes from Diabetic and Control SubjectsThrombosis and Haemostasis, 67
N. Seecheran, Neval Nandlal, Sushanta Nankissoon, Cherisse Nancoo, C. Nelson, Austell Nkemakolam, N. Noel, Kwame Olivers, R. Parasram, Mario Rodriguez, R. Seecheran, Valmiki Seecheran, S. Persad, R. Ramlal, A. Maharaj, Brent Boodhai, K. Ramsaroop, Mohanchan Motilal (2017)
A trinidadian cardiovascular medication adherence survey: the ADHERE TNT studyInternational Journal of Community Medicine and Public Health, 4
R. Handin, R. Karabin, G. Boxer (1977)
Enhancement of platelet function by superoxide anion.The Journal of clinical investigation, 59 5
U. Tantry, L. Bonello, D. Aradi, M. Price, Y. Jeong, D. Angiolillo, G. Stone, N. Curzen, T. Geisler, J. Berg, A. Kirtane, J. Siller-Matula, E. Mahla, R. Becker, Deepak Bhatt, R. Waksman, S. Rao, D. Alexopoulos, R. Marcucci, J. Reny, D. Trenk, D. Sibbing, P. Gurbel (2013)
Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding.Journal of the American College of Cardiology, 62 24
Ferdinando Giacco, M. Brownlee (2010)
Oxidative stress and diabetic complications.Circulation research, 107 9
Amar Ali, S. Bain, D. Hicks, Phillip Jones, D. Patel, M. Evans, Kevin Fernando, J. James, N. Milne, A. Viljoen, J. Wilding (2019)
SGLT2 Inhibitors: Cardiovascular Benefits Beyond HbA1c—Translating Evidence into PracticeDiabetes Therapy, 10
R. Holman, S. Paul, M. Bethel, D. Matthews, H. Andrew, W. Neil (2008)
10-year follow-up of intensive glucose control in type 2 diabetes.The New England journal of medicine, 359 15
M. Ranucci, Tommaso Aloisio, U. Dedda, M. Rovere, Blanca Arroyabe, E. Baryshnikova (2018)
Platelet reactivity in overweight and obese patients undergoing cardiac surgery.Platelets, 30 5
(2013)
World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects.JAMA, 310 20
R. Cook, B. Dickens, M. Fathalla (2003)
World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects.The Journal of the American College of Dentists, 81 3
B. Zinman, C. Wanner, J. Lachin, D. Fitchett, E. Bluhmki, S. Hantel, M. Mattheus, T. Devins, O. Johansen, H. Woerle, U. Broedl, S. Inzucchi (2015)
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes.The New England journal of medicine, 373 22
J. Pedreño, E. Hurt-Camejo, O. Wiklund, L. Badimón, L. Masana (2000)
Platelet function in patients with familial hypertriglyceridemia: evidence that platelet reactivity is modulated by apolipoprotein E content of very-low-density lipoprotein particles.Metabolism: clinical and experimental, 49 7
N. Seecheran, Victoria Seebalack, R. Seecheran, A. Maharaj, Brent Boodhai, Valmiki Seecheran, S. Persad, Mohanchan Motilal, A. Tello-Montoliu, D. Schneider (2019)
TRimetazidine as an Agent to affeCt clopidogrEl Response: The TRACER StudyCardiology and Therapy, 8
Tushar Madaan, Ibraheem Husain, M. Akhtar, A. Najmi (2018)
Exploring novel pharmacotherapeutic applications and repurposing potential of sodium glucose CoTransporter 2 inhibitorsClinical and Experimental Pharmacology and Physiology, 45
N. Seecheran, Brent Boodhai, A. Maharaj, Arvinash Ramdeen, Niranjan Debideen, Vishesh Ochalal, Ranweer Singh, R. Seecheran, Valmiki Seecheran, S. Persad, Harun Abdullah, Lakshmipathi Peram, S. Motilal, A. Tello-Montoliu, David Schneider (2020)
The Effect of Low-Dose Ticagrelor on Platelet Function Profiles in Patients With Stable Coronary Artery Disease in Trinidad: The TWIST Pilot StudyCardiology and Therapy, 9
S. Verma, J. McMurray (2018)
SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art reviewDiabetologia, 61
C. Komiya, K. Tsuchiya, K. Shiba, Yasutaka Miyachi, Shunsaku Furuke, N. Shimazu, Shinobu Yamaguchi, Kazuo Kanno, Yoshihiro Ogawa (2016)
Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight ReductionPLoS ONE, 11
N. Seecheran, S. Baldeo, Khadia Balbosa, Salisha Baksh, Shantel Bethelmy, S. Balkaran, Karishma Bhagaloo, P. Bethel, R. Seecheran, Mario Rodriguez, Valmiki Seecheran, R. Ramlal, S. Persad, Mohanchan Motilal (2017)
Epidemiologic insight into Trinidad’s awareness and prevention of heart disease. The EPITAPH study - a trinidadian cardiovascular health literacy surveyInternational Journal of Community Medicine and Public Health, 4
Norihisa Nishimura, Mitsuteru Kitade, R. Noguchi, T. Namisaki, K. Moriya, K. Takeda, Yasushi Okura, Y. Aihara, A. Douhara, H. Kawaratani, K. Asada, H. Yoshiji (2016)
Ipragliflozin, a sodium–glucose cotransporter 2 inhibitor, ameliorates the development of liver fibrosis in diabetic Otsuka Long–Evans Tokushima fatty ratsJournal of Gastroenterology, 51
Christiane, Druml, Wolzt, Pleiner (2000)
World Medical Association Declaration of HelsinkiInternational Journal of Pharmaceutical Medicine, 14
A. Schäfer, J. Bauersachs (2008)
Endothelial dysfunction, impaired endogenous platelet inhibition and platelet activation in diabetes and atherosclerosis.Current vascular pharmacology, 6 1
JukkaWesterbacka, HanneleYki-Järvinen, AnuTurpeinen, AilaRissanen, SatuVehkavaara, MarttiSyrjälä, RiittaLassila (2002)
Inhibition of Platelet-Collagen Interaction
J. Freedman (2008)
Oxidative stress and platelets.Arteriosclerosis, thrombosis, and vascular biology, 28 3
G. Schaeffer, T. Wascher, G. Kostner, W. Graier (1999)
Alterations in platelet Ca2+ signalling in diabetic patients is due to increased formation of superoxide anions and reduced nitric oxide productionDiabetologia, 42
U. Förstermann, N. Xia, Huige Li (2017)
Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of AtherosclerosisCirculation Research, 120
R. Assert, G. Scherk, A. Bumbure, V. Pīrāgs, H. Schatz, A. Pfeiffer (2001)
Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitroDiabetologia, 44
M. Nassif, Sheryl Windsor, F. Tang, Yevgeniy Khariton, M. Husain, S. Inzucchi, D. McGuire, B. Pitt, B. Scirica, B. Austin, M. Drazner, Michael Fong, M. Givertz, R. Gordon, R. Jermyn, S. Katz, S. Lamba, D. Lanfear, S. Larue, J. Lindenfeld, M. Malone, K. Margulies, R. Mentz, R. Mutharasan, M. Pursley, G. Umpierrez, M. Kosiborod, A. Malik, Nannette Wenger, Modele Ogunniyi, P. Vellanki, B. Murphy, J. Newman, J. Hartupee, Charu Gupta, Marcela Goldsmith, Paramdeep Baweja, M. Montero, S. Gottlieb, M. Costanzo, Thanh Hoang, A. Warnock, L. Allen, Wilson Tang, Horng Chen, J. Cox (2019)
Dapagliflozin Effects on Biomarkers, Symptoms, and Functional Status in Patients With Heart Failure With Reduced Ejection Fraction: The DEFINE-HF Trial.Circulation
A. Scheen (2020)
Reduction in HbA1c with SGLT2 inhibitors vs DPP-4 inhibitors as add-ons to metformin monotherapy according to baseline HbA1c: a systematic review of randomized controlled trials.Diabetes & metabolism
Sandeep Das, Brendan Everett, K. Birtcher, Jenifer Brown, J. Januzzi, R. Kalyani, M. Kosiborod, M. Magwire, P. Morris, Joshua Neumiller, L. Sperling (2020)
2020 Expert Consensus Decision Pathway on Novel Therapies for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes: A Report of the American College of Cardiology Solution Set Oversight Committee.Journal of the American College of Cardiology
D. Schneider (2009)
Factors Contributing to Increased Platelet Reactivity in People With DiabetesDiabetes Care, 32
F. Keating, B. Sobel, D. Schneider (2003)
Effects of increased concentrations of glucose on platelet reactivity in healthy subjects and in patients with and without diabetes mellitus.The American journal of cardiology, 92 11
A. Tahara, E. Kurosaki, Masanori Yokono, Daisuke Yamajuku, Rumi Kihara, Yuka Hayashizaki, T. Takasu, Masakazu Imamura, Qun Li, H. Tomiyama, Yoshinori Kobayashi, Atsushi Noda, M. Sasamata, M. Shibasaki (2014)
Effects of sodium‐glucose cotransporter 2 selective inhibitor ipragliflozin on hyperglycaemia, oxidative stress, inflammation and liver injury in streptozotocin‐induced type 1 diabetic ratsJournal of Pharmacy and Pharmacology, 66
V. Vallon, S. Thomson (2017)
Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibitionDiabetologia, 60
IntroductionThis prospective pharmacodynamic (PD) study aimed to assess the effect of the sodium–glucose cotransporter 2 inhibitor (SGLT2i) empagliflozin on platelet reactivity.MethodsPatients with stable coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) (n = 20) who were actively treated with dual antiplatelet therapy (DAPT) of aspirin 81 mg daily and clopidogrel 75 mg daily were recruited. Platelet function was measured with the VerifyNow™ P2Y12 assay (Instrumentation Laboratory, Massachusetts, USA) and assessed before the initiation of and after 10 days of treatment with empagliflozin 25 mg once daily maintenance dose regimen. Results were compared with a paired t test.ResultsThe mean P2Y12 reaction units (PRU) on empagliflozin was significantly less than without empagliflozin at baseline (187.35, 95% confidence interval (CI) 155.38–219.32 vs. 217.25, CI 180.60–253.90; p < 0.030). The mean difference in PRU was 29.90 (95% CI 3.17–56.63). No patients experienced any serious adverse events (SAEs).ConclusionsSignificantly attenuated platelet reactivity was observed on empagliflozin as compared to without empagliflozin. This dedicated pharmacodynamic study could be clinically pertinent for Trinidadian patients with stable CAD and T2DM on DAPT. Further studies are required to confirm these exploratory findings. (Funded by the University of the West Indies, St. Augustine; EFFECT).Clinical Trial RegistrationClinicalTrials.gov number NCT04342819.
Cardiology and Therapy – Springer Journals
Published: Dec 11, 2020
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.