Access the full text.
Sign up today, get DeepDyve free for 14 days.
A. Hoffman (2001)
Hydrogels for Biomedical ApplicationsAnnals of the New York Academy of Sciences, 944
Y. Tien, Po-Lin Wu, Wei-Hsing Huang, M. Kuo, C. Chu (2007)
Wall friction measurement and compaction characteristics of bentonite powdersPowder Technology, 173
A. Hodsdon, J. Mitchell, M. Davies, C. Melia (1995)
Structure and behaviour in hydrophilic matrix sustained release dosage forms: 3. The influence of pH on the sustained-release performance and internal gel structure of sodium alginate matricesJournal of Controlled Release, 33
D. Tada, T. Tanabe, A. Tachibana, K. Yamauchi (2007)
Albumin-crosslinked alginate hydrogels as sustained drug release carrierMaterials Science and Engineering: C, 27
K. Br (2000)
Current status of DNA vaccines in veterinary medicine.Advanced Drug Delivery Reviews, 43
P. Finotelli, M. Morales, M. Rocha-Leão, E. Baggio-Saitovitch, A. Rossi (2004)
Magnetic studies of iron(III) nanoparticles in alginate polymer for drug delivery applicationsMaterials Science and Engineering: C, 24
W. Hennink, C. Nostrum (2002)
Novel crosslinking methods to design hydrogelsAdvanced Drug Delivery Reviews, 54
L. Chan, H.Y Lee, P.W.S Heng (2002)
Production of alginate microspheres by internal gelation using an emulsification method.International journal of pharmaceutics, 242 1-2
S. Sakai, T. Ono, H. Ijima, K. Kawakami (2004)
Behavior of enclosed sol- and gel-alginates in vivoBiochemical Engineering Journal, 22
C. Chretien, J. Chaumeil (2005)
Release of a macromolecular drug from alginate-impregnated microspheres.International journal of pharmaceutics, 304 1-2
Sung-Ching Chen, Yung-Chih Wu, F. Mi, Yu-Hsin Lin, L. Yu, Hsing‐Wen Sung (2004)
A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery.Journal of controlled release : official journal of the Controlled Release Society, 96 2
F. Iemma, U. Spizzirri, F. Puoci, R. Muzzalupo, S. Trombino, R. Cassano, Sonia Leta, N. Picci (2006)
pH-sensitive hydrogels based on bovine serum albumin for oral drug delivery.International journal of pharmaceutics, 312 1-2
L. Chan, Huey Lee, P. Heng (2006)
Mechanisms of external and internal gelation and their impact on the functions of alginate as a coat and delivery systemCarbohydrate Polymers, 63
Seong-Ryul Yang, Oh-Jin Kwon, Daehan Kim, Jongshin Park (2007)
Characterization of the polyurethane foam using alginic acid as a polyolFibers and Polymers, 8
Zhanfeng Dong, Qun Wang, Yumin Du (2006)
Alginate/gelatin blend films and their properties for drug controlled releaseJournal of Membrane Science, 280
P. Liebmann, G. Loew, S. Burt, J. Lawless, R. MacElroy (1982)
Interaction of metal ions and nucleotides: possible mechanisms for the adsorption of nucleotides on homoionic bentonite claysInorganic Chemistry, 21
Bassem Mostafa, F. Assaad (2007)
Rheological and electrical properties of bentonite in anionic polystyrene sulfonate and nonionic poly(vinyl alcohol)Journal of Applied Polymer Science, 104
C. Gray, J. Dowsett (1988)
Retention of insulin in alginate gel beads.Biotechnology and bioengineering, 31 6
Oh-Jin Kwon, Seung-Taek Oh, Sang‐Do Lee, Nari Lee, C. Shin, Jongshin Park (2007)
Hydrophilic and flexible polyurethane foams using sodium alginate as polyol: Effects of PEG molecular weight and cross-linking agent content on water absorbencyFibers and Polymers, 8
F. Garrido-Herrera, E. González-Pradas, M. Fernández-Pérez (2006)
Controlled release of isoproturon, imidacloprid, and cyromazine from alginate-bentonite-activated carbon formulations.Journal of agricultural and food chemistry, 54 26
P. Eiselt, J. Yeh, Rachel Latvala, L. Shea, D. Mooney (2000)
Porous carriers for biomedical applications based on alginate hydrogels.Biomaterials, 21 19
Chong-K. Kim, Eun-Jin Lee (1992)
The controlled release of blue dextran from alginate beadsInternational Journal of Pharmaceutics, 79
A. S. Hoffman (2002)
10.1016/S0169-409X(01)00239-3Adv. Drug Delivery Rev., 43
M. Fernández-Pérez, E. González-Pradas, M. Villafranca-Sánchez, F. Flores-Céspedes (2000)
Mobility of isoproturon from an alginate-bentonite controlled release formulation in layered soil.Chemosphere, 41 9
P. Aslani, R. Kennedy (1996)
Studies on diffusion in alginate gels. I. Effect of cross-linking with calcium or zinc ions on diffusion of acetaminophenJournal of Controlled Release, 42
Abstract We produced a protein loaded, pH-sensitive alginate-bentonite hydrogel for wound dressings. Alginate is a nontoxic polysaccharide with favorable pH-sensitive properties that make it useful for the intestinal delivery of protein drugs. However, the use of alginate for drug delivery is limited by drug leaching and rapid dissolution of alginate at the higher pH, which may result in lower entrapment efficiency and a burst in the release of entrapped protein drugs. To overcome these problems, we created a novel cross-linked alginate-bentonite hydrogel by combining mineral-rich bentonite with the alginate matrix along with an additive to ensure controlled release. We analyzed the gel in the drug loading process in an aqueous environment by looking at the release profiles of a model protein drug (BSA) from the hydrogel at pH values of 4.5, 5.2 (skin area) and 7.4, 9.2 (wound area). The swelling ratio decreased with bentonite concentration, but did not fall below 6. The rate of drug release was slowest at a pH value of 4.5 and fastest at a pH value of 9.2. The rate of drug release decreased with bentonite concentration. The presence of bentonite prevents the rapid dissolution of alginate at the higher pH, ensuring the controlled release of the entrapped drug.
Fibers and Polymers – Springer Journals
Published: Feb 1, 2009
Keywords: Polymer Sciences
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.