Access the full text.
Sign up today, get DeepDyve free for 14 days.
Haizhong Huo, B. Wang, Yong-kang Liang, Yongzhan Bao, Yan Gu (2011)
Hepatoprotective and Antioxidant Effects of Licorice Extract against CCl4-Induced Oxidative Damage in RatsInternational Journal of Molecular Sciences, 12
S. Boshra, Prof. Hussein (2014)
THE PROTECTIVE ROLE OF COLCHICINE ON DICLOFENAC SODIUM INDUCED HEPATORENAL TOXICITY IN ALBINO RATS MODEL
M. Farzaei, M. Zangeneh, N. Goodarzi, Akram Zangeneh (2018)
Stereological Assessment of Nephroprotective Effects of Trachyspermum ammi Essential Oil against Carbon Tetrachloride-Induced Nephrotoxicity in MiceInternational Journal of Morphology
Julian Higgins, Sally Green (2010)
Cochrane Handbook for Systematic Reviews of InterventionsInternational Coaching Psychology Review
Taymour Sayyedrostami, P. Pournaghi, Soheila Vosta-Kalaee, M. Zangeneh (2018)
Evaluation of the Wound Healing Activity of Chenopodium botrys Leaves Essential Oil in Rats (A Short-Term Study)Journal of Essential Oil Bearing Plants, 21
Hong-Jhang Chen, Shuai Kang, I-Jung Lee, Yun-Lian Lin (2014)
Glycyrrhetinic acid suppressed NF-κB activation in TNF-α-induced hepatocytes.Journal of agricultural and food chemistry, 62 3
B. Reeves, J. Deeks, J. Higgins, G. Wells (2008)
Including Non‐Randomized Studies
R. Adams, S. Appleton, T. Gill, Anne Taylor, David Wilson, C. Hill (2011)
Cause for concern in the use of non-steroidal anti-inflammatory medications in the community -a population-based studyBMC Family Practice, 12
T. Mizui, H. Sato, F. Hirose, M. Doteuchi (1987)
Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats.Life sciences, 41 6
V. Dwivedi, J. Mishra, A. Shrivastava (2016)
Efficacy Study of Livartho against Paracetamol Induced Hepatotoxicity in Adult Sprague Dawley RatsJournal of Drug Metabolism and Toxicology, 5
Marta Capone, S. Tacconelli, L. Francesco, A. Sacchetti, M. Sciulli, P. Patrignani (2007)
Pharmacodynamic of cyclooxygenase inhibitors in humans.Prostaglandins & other lipid mediators, 82 1-4
Mona Hamelian, M. Zangeneh, A. Amisama, Kambiz Varmira, H. Veisi (2018)
Green synthesis of silver nanoparticles using Thymus kotschyanus extract and evaluation of their antioxidant, antibacterial and cytotoxic effectsApplied Organometallic Chemistry
H. Sherkatolabbasieh, Lida Hagh-Nazari, Shiva Shafiezadeh, N. Goodarzi, M. Mehdi, Zangeneh, Akram Zangeneh (2017)
Ameliorative effects of the ethanolic extract of Allium saralicum R.M. Fritsch on CCl4-induced nephrotoxicity in mice: A stereological examinationArchives of Biological Sciences, 69
(2011)
Screening and characterization of natural antioxidants in four Glycyrrhiza species by liquid chromatography coupled with electrospray ionization quadrupole time-offlight tandem mass spectrometry
Aprioku J.S, Uche F.I (2013)
Renal Effects of Non-Steroidal Anti Inflammatory Drugs in Albino RatsBritish journal of pharmaceutical research, 3
Orinya Orinya, A. Adenkola, R. Ogbe (2017)
Haematological and biochemical studies on the effect of diclofenac sodium on Wistar Rattus norvegicusInternational Journal of Biological and Chemical Sciences, 10
(2012)
Haemato-biochemical studies on diclofenac, ibuprofen and nimesulide induced toxicity in broilers
M. Zangeneh, Saman Salmani, Akram Zangeneh, E. Bahrami, M. Almasi (2018)
Antiulcer activity of aqueous extract of leaves of Mentha piperita in Wistar ratsComparative Clinical Pathology, 28
A. Yashin, Y. Yashin, Xiaoyan Xia, B. Nemzer (2017)
Antioxidant Activity of Spices and Their Impact on Human Health: A ReviewAntioxidants, 6
R. Moradi, Majid Hajialiani, Saman Salmani, M. Almasi, Akram Zangeneh, M. Zangeneh (2018)
Effect of aqueous extract of Allium saralicum R.M. Fritsch on fatty liver induced by high-fat diet in Wistar ratsComparative Clinical Pathology
A. Sonnenberg, M. Chicarro (1991)
[Peptic ulcer in the United States].Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva, 79 5
(1982)
Aspirin and similar analgesic and anti-inflammatory agents
MD Anderson, SE Piper, GE Swan (2005)
Nonsteroidal anti-inflammatory drug use in South Africa and possible effects on vulturesS Afr J Anim Sci, 101
A. Samadnejad, S. Mehrvarz, S. Naeini, N. Tanideh (2012)
Healing effect of Licorice extract in acetic acid-induced ulcerative colitis in ratResearch in Pharmaceutical Sciences, 7
Basavraj Thanagari, D. Fefar, K. Prajapati, B. Jivani, K. Thakor, J. Patel, D. Ghodasara, B. Joshi, V. Undhad (2012)
Haemato-biochemical alterations induced by Diclofenac sodium toxicity in Swiss albino mice.Veterinary World, 5
M. Anderson, S. Piper, G. Swan (2005)
Non-steroidal anti-inflammatory drug use in south africa and possible effects on vulturesSouth African Journal of Science, 101
M. Orme (1986)
Non-steroidal anti-inflammatory drugs and the kidney.British Medical Journal (Clinical research ed.), 292
Hui Liu, Jinan Wang, W. Zhou, Yonghua Wang, Ling Yang (2013)
Systems approaches and polypharmacology for drug discovery from herbal medicines: an example using licorice.Journal of ethnopharmacology, 146 3
Yan-jing Li, Jun Chen, Y. Li, Qin Li, Yunfeng Zheng, Yu Fu, Ping Li (2011)
Screening and characterization of natural antioxidants in four Glycyrrhiza species by liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.Journal of chromatography. A, 1218 45
G. Traversa, A. Walker, F. Ippolito, B. Caffari, L. Capurso, A. Dezi, M. Koch, M. Maggini, S. Alegiani, R. Raschetti (1995)
GASTRODUODENAL TOXICITY OF DIFFERENT NONSTEROIDAL ANTIINFLAMMATORY DRUGSEpidemiology, 6
Krupa Patel, C. Diamantidis, M. Zhan, V. Hsu, Loreen Walker, J. Gardner, M. Weir, J. Fink (2012)
Influence of Creatinine versus Glomerular Filtration Rate on Non-Steroidal Anti-Inflammatory Drug Prescriptions in Chronic Kidney DiseaseAmerican Journal of Nephrology, 36
M. Zangeneh, Akram Zangeneh, R. Tahvilian, R. Moradi (2018)
Evaluation of the nephroprotective effect of Glycyrrhiza glabra L aqueous extract on CCl4-induced nephrotoxicity in miceComparative Clinical Pathology, 27
G. Graham, M. Davies, R. Day, A. Mohamudally, K. Scott (2013)
The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findingsInflammopharmacology, 21
EF Reynolds (1982)
Martindale. The extra pharmacopoeia
W. Bennett, W. Bennett, W. Bennett, W. Henrich, W. Henrich, W. Henrich, J. Stoff, J. Stoff, J. Stoff (1996)
The renal effects of nonsteroidal anti-inflammatory drugs: summary and recommendations.American journal of kidney diseases : the official journal of the National Kidney Foundation, 28 1 Suppl 1
(2001)
Ibuprofen affects proand anti-inflammatory cytokine production by mononuclear cells of preterm newborns. Biol Neonate
(2006)
Repairing effect of hydroalcoholic extract of aerial part of Facaria vulgaris on aspirin- induced gastric ulcers in rat
S. Hull, R. Mathur, G. Dreyer, M. Yaqoob (2014)
Evaluating ethnic differences in the prescription of NSAIDs for chronic kidney disease: a cross-sectional survey of patients in general practice.The British journal of general practice : the journal of the Royal College of General Practitioners, 64 624
L. Sirota, D. Shacham, I. Punsky, H. Bessler (2001)
Ibuprofen Affects Pro- and Anti-Inflammatory Cytokine Production by Mononuclear Cells of Preterm NewbornsNeonatology, 79
P. Montoro, M. Maldini, M. Russo, S. Postorino, S. Piacente, C. Pizza (2011)
Metabolic profiling of roots of liquorice (Glycyrrhiza glabra) from different geographical areas by ESI/MS/MS and determination of major metabolites by LC-ESI/MS and LC-ESI/MS/MS.Journal of pharmaceutical and biomedical analysis, 54 3
S. Alqasoumi, M. Al-Sohaibani, T. Al-Howiriny, M. Al-yahya, S. Rafatullah (2009)
Rocket "Eruca sativa": a salad herb with potential gastric anti-ulcer activity.World journal of gastroenterology, 15 16
SK Swan, DW Rudy, KC Lasseter, CF Ryan, KL Buechel, LJ Lambrecht, MB Pinto, SC Dilzer, O Obrda, KJ Sundblad, CP Gumbs, DL Ebel, H Quan, PJ Larson, JI Schwartz, TA Musliner, BJ Gertz, DC Brater, SL Yao (2000)
Effect of cyclooxygenase-2 inhibition on renal function in elderly persons receiving a low-salt diet. A randomized, controlled trialAnn Intern Med, 133
H. Kitagawa, R. Iwaki (1963)
[PHARMACOLOGICAL STUDY ON PANAX GINSEG].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 59
Z. Kh, I. El-Ashmawy, S. Arabia (2013)
Hepato-Renal and Hematological Effects of Diclofenac Sodium in Rats
M. Zangeneh, Saman Salmani, Akram Zangeneh, Reza Khedri, Mohammad Zarei (2018)
Histopathological and biochemical effects of aqueous extract of Tragopogon graminifolius on the liver tissues of Wistar rats fed with high-fat dietComparative Clinical Pathology
H. Matsuda, M. Kubo (1984)
[Pharmacological study on Panax ginseng C. A. Meyer. II. Effects of red ginseng on the experimental gastric ulcer (1)].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 104 5
R. Bushra, N. Aslam (2010)
An overview of clinical pharmacology of Ibuprofen.Oman medical journal, 25 3
(2012)
Review on Glycyrrhiza glabra
Marjan Nassiri-Asl, H. Hosseinzadeh (2008)
Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive CompoundsPhytotherapy Research, 22
A. Bendele, James Hulman, Sandy White, C. Brodhecker, R. Bendele (1993)
Hepatocellular Proliferation in Ibuprofen-Treated MiceToxicologic Pathology, 21
(2014)
Glycyrrhetinic acid suppressed NF-kappaB activation in TNF-alpha-induced hepatocytes
Andrew Whelton, Gerald Schulman, Carl Wallemark, Edward Drower, Peter Isakson, K. Verburg, G. Geis (2000)
Effects of celecoxib and naproxen on renal function in the elderly.Archives of internal medicine, 160 10
Jae-chul Jung, Yun-Hee Lee, S. Kim, Keuk-Jun Kim, Kyung-Mi Kim, Seikwan Oh, Young-Suk Jung (2015)
Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver diseaseBMC Complementary and Alternative Medicine, 16
Guo-Jun Yin, Li-ping Cao, P. Xu, Galina Jeney, M. Nakao, Chengping Lu (2011)
Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract against carbon tetrachloride (CCl4)-induced hepatocyte damage in common carp (Cyprinus carpio)Fish Physiology and Biochemistry, 37
(2018)
Histopathological and biochemical effects of aqueous extract of Tragopogon graminifolius on the liver tissues ofWistar rats fed with high-fat diet
S. Swan, D. Rudy, K. Lasseter, C. Ryan, K. Buechel, L. Lambrecht, Manuel Pinto, S. Dilzer, O. Obrda, K. Sundblad, C. Gumbs, D. Ebel, H. Quan, Patrick Larson, J. Schwartz, T. Musliner, B. Gertz, D. Brater, S. Yao (2000)
Effect of Cyclooxygenase-2 Inhibition on Renal Function in Elderly Persons Receiving a Low-Salt DietAnnals of Internal Medicine, 133
L. Sadiq (2016)
HEPATOPROTECTIVE EFFECT OF GLYCYRRHIZA GLABRA L . EXTRACTS AGAINST CARBON TETRACHLORIDE-INDUCED ACUTE LIVER DAMAGE IN RATS
M. Zhaleh, N. Sohrabi, M. Zangeneh, Akram Zangeneh, R. Moradi, H. Zhaleh (2018)
Chemical Composition and Antibacterial Effects of Essential Oil of Rhus coriaria Fruits in the West of Iran (Kermanshah)Journal of Essential Oil Bearing Plants, 21
L. Tafti, S. Shariatpanahi, M. Damghani, B. Javadi (2017)
Traditional Persian topical medications for gastrointestinal diseasesIranian Journal of Basic Medical Sciences, 20
The recent studies have indicated the properties of ethnomedicinal plants in the prevention, control, and treatment of gastroduodenal ulcers. Glycyrrhiza glabra has been used in Iranian traditional medicine as a therapeutic supplement. The aim of our research was to survey the preventive property of aqueous extract of G. glabra leaf on ibuprofen-induced gastroduodenal ulcers by investigating the biochemical, hematological, immunological, and microscopic approaches in rats. In this study, 60 rats were used. The animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, the positive control receiving omeprazole 60 mg/kg, and three groups receiving the G. glabra aqueous extract at 20 mg/kg, 60 mg/kg, and 180 mg/kg concentrations. After 14 days, gastroduodenal ulcers were caused by ibuprofen 400 mg/kg. Four hours after oral administration of ibuprofen, the rats were sacrificed and blood, stomach, and duodenum samples of them collected for analysis of biochemical, hematological, immunological, and microscopic parameters. The data were analyzed by SPSS 21 software. All doses of G. glabra could significantly (p ≤ 0.05) reduce the raised levels of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, urea, creatinine, IL-1, IL-6, IL-12, IL-18, IFN-γ, and TNF-α and increase HDL, total protein, albumin, WBC, platelet, RBC, IL-4, IL-5, IL-10, IL-13, and IFN-α as compared to the untreated group. Also, aqueous extract of G. glabra prevented significantly (p ≤ 0.05) gastroduodenal ulcers as compared to the untreated group. In conclusion, the obtained results indicated the hepatoprotective, nephroprotective, hematoprotective, immunoprotective, and gastroduodenal protective properties of G. glabra aqueous extract.
Comparative Clinical Pathology – Springer Journals
Published: Nov 7, 2018
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.