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- Publisher
- Springer Journals
- Copyright
- Copyright © 2011 by Springer Science+Business Media, LLC
- Subject
- Medicine & Public Health; Surgical Oncology; Oncology; Internal Medicine
- ISSN
- 1943-4588
- eISSN
- 1943-4596
- DOI
- 10.1007/s12609-011-0059-z
- Publisher site
- See Article on Publisher Site
Abstract
The androgen receptor (AR) is expressed in 70–90% of invasive breast cancers. Despite the ubiquitous expression of AR in both primary and metastatic breast cancers, the clinical significance of this hormone receptor as a prognostic/predictive marker and its functional role in tumorigenesis remains poorly understood. This review summarizes the recent progress made in understanding the role of the AR as a prognostic/predictive marker in breast cancer and the underlying mechanisms by which the androgen-signaling pathway may be involved in breast cancer pathogenesis. In addition, this review examines the available clinical data for the use of androgen-blocking agents in the treatment of breast cancer and explores the ongoing development of newer AR-targeted agents in this setting.
Journal
Current Breast Cancer Reports – Springer Journals
Published: Dec 28, 2011