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S. Serratì, F. Margheri, M. Pucci, A. Cantelmo, R. Cammarota, J. Dotor, F. Borrás-Cuesta, G. Fibbi, A. Albini, M. Rosso (2009)
TGFbeta1 antagonistic peptides inhibit TGFbeta1-dependent angiogenesis.Biochemical pharmacology, 77 5
G. Clines, T. Guise (2005)
Hypercalcaemia of malignancy and basic research on mechanisms responsible for osteolytic and osteoblastic metastasis to bone.Endocrine-related cancer, 12 3
A. Bandyopadhyay, F. López‐Casillas, Shazli Malik, J. Montiel, Valentı́n Mendoza, Junhua Yang, L-Z. Sun (2002)
Antitumor activity of a recombinant soluble betaglycan in human breast cancer xenograft.Cancer research, 62 16
J. Massagué (2000)
How cells read TGF-beta signals.Nature reviews. Molecular cell biology, 1 3
Anna Mead, Tina Wong, M. Cordeiro, Ian Anderson, P. Khaw (2003)
Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery.Investigative ophthalmology & visual science, 44 8
Masayoshi Tojo, Y. Hamashima, A. Hanyu, T. Kajimoto, M. Saitoh, K. Miyazono, M. Node, T. Imamura (2005)
The ALK‐5 inhibitor A‐83‐01 inhibits Smad signaling and epithelial‐to‐mesenchymal transition by transforming growth factor‐βCancer Science, 96
Irwin Liu, Stephen Schilling, Kristin Knouse, L. Choy, R. Derynck, Xiao-Fan Wang (2009)
TGFβ‐stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro‐migratory TGFβ switchThe EMBO Journal, 28
M. Calonge, J. Massagué (1999)
Smad4/DPC4 Silencing and Hyperactive Ras Jointly Disrupt Transforming Growth Factor-β Antiproliferative Responses in Colon Cancer Cells*The Journal of Biological Chemistry, 274
Saeid, M., Seyedin, Andrea, Y., Thompson, Hanne BentzS, David, RosenS, John, McPhersonS, A. Conti, Ned, R., SiegelT, Gerald Galluppi, Karl, A., Piez (1986)
Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta.The Journal of biological chemistry, 261 13
M. Korpal, Jun-Hai Yan, Xin Lu, Shuwa Xu, Dorothy Lerit, Yibin Kang (2009)
Imaging transforming growth factor-β signaling dynamics and therapeutic response in breast cancer bone metastasisNature Medicine, 15
Fenghua Kong, M. Anscher, T. Murase, B. Abbott, J. Iglehart, R. Jirtle (1995)
Elevated Plasma Transforming Growth Factor-β1 Levels in Breast Cancer Patients Decrease After Surgical Removal of the TumorAnnals of Surgery, 222
J. Baselga, M. Rothenberg, J. Tabernero, J. Seoane, T. Daly, A. Cleverly, Brandi Berry, S. Rhoades, Chad Ray, J. Fill, D. Farrington, Lisa Wallace, J. Yingling, M. Lahn, C. Arteaga, M. Carducci (2008)
TGF-β signalling-related markers in cancer patients with bone metastasisBiomarkers, 13
M. Goumans, Gudrun Valdimarsdottir, S. Itoh, F. Lebrin, Jonas Larsson, C. Mummery, S. Karlsson, P. Dijke (2003)
Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling.Molecular cell, 12 4
P. Simic, S. Vukicevic (2005)
Bone morphogenetic proteins in development and homeostasis of kidney.Cytokine & growth factor reviews, 16 3
A. Dudley, K. Lyons, K. Lyons, E. Robertson (1995)
A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.Genes & development, 9 22
K. Schlingensiepen, A. Bischof, T. Egger, M. Hafner, H. Herrmuth, P. Jachimczak, M. Kielmanowicz, M. Niewel, E. Zavadova, G. Stauder (2004)
The TGF-beta1 antisense oligonucleotide AP 11014 for the treatment of non-small cell lung, colorectal and prostate cancer: Preclinical studies.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 22 14_suppl
Zhen Liu, Kazuki Kobayashi, Maarten Dinther, S. Heiningen, Gudrun Valdimarsdottir, T. Laar, M. Scharpfenecker, C. Löwik, M. Goumans, P. Dijke, E. Pardali (2009)
VEGF and inhibitors of TGFβ type-I receptor kinase synergistically promote blood-vessel formation by inducing α5-integrin expressionJournal of Cell Science, 122
L. Gorelik, R. Flavell (2000)
Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune DiseaseImmunity, 12
Thomas-Toan Tran, M. Uhl, J. Ma, L. Janssen, V. Sriram, Steffen Aulwurm, I. Kerr, Andrew Lam, H. Webb, A. Kapoun, D. Kizer, G. Mcenroe, B. Hart, J. Axon, Alison Murphy, S. Chakravarty, S. Dugar, A. Protter, L. Higgins, W. Wick, M. Weller, Darren Wong (2007)
Inhibiting TGF-beta signaling restores immune surveillance in the SMA-560 glioma model.Neuro-oncology, 9 3
C. O’Brien, A. Pollett, S. Gallinger, J. Dick (2007)
A human colon cancer cell capable of initiating tumour growth in immunodeficient miceNature, 445
Xiangwei Wu, Lijuan Pang, Weiqi Lei, W. Lu, Jun Li, Z. Li, F. Frassica, Xueling Chen, M. Wan, Xu Cao (2010)
Inhibition of Sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling.Cell stem cell, 7 5
J. Thompson, T. Vaughan, A. Williams, J. Wilton, K. Johnson, L. Bacon, J. Green, R. Field, S. Ruddock, M. Martins, A. Pope, P. Tempest, R. Jackson (1999)
A fully human antibody neutralising biologically active human TGFbeta2 for use in therapy.Journal of immunological methods, 227 1-2
A Jemal (2011)
69CA Canc J Clin, 61
K Janssens, P Dijke, S Janssens, W Hul (2005)
Transforming growth factor-beta1 to the boneEndocr Rev, 26
G. Inman, F. Nicolás, J. Callahan, J. Harling, L. Gaster, A. Reith, N. Laping, C. Hill (2002)
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.Molecular pharmacology, 62 1
J. Quinn, K. Itoh, N. Udagawa, Karl Häusler, H. Yasuda, N. Shima, A. Mizuno, K. Higashio, N. Takahashi, T. Suda, T. Martin, M. Gillespie (2001)
Transforming Growth Factor β Affects Osteoclast Differentiation via Direct and Indirect ActionsJournal of Bone and Mineral Research, 16
T. Guise, J. Yin, Suzanne Taylor, Y. Kumagai, M. Dallas, B. Boyce, T. Yoneda, G. Mundy (1996)
Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis.The Journal of clinical investigation, 98 7
J. Buijs, G. Pluijm (2009)
Osteotropic cancers: from primary tumor to bone.Cancer letters, 273 2
P. Bonniaud, P. Margetts, M. Kolb, Jane Schroeder, A. Kapoun, Debby Damm, Alison Murphy, S. Chakravarty, S. Dugar, L. Higgins, A. Protter, J. Gauldie (2005)
Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor.American journal of respiratory and critical care medicine, 171 8
J. Buijs, M. Petersen, G. Horst, G. Pluijm (2010)
Bone morphogenetic proteins and its receptors; therapeutic targets in cancer progression and bone metastasis?Current pharmaceutical design, 16 11
J. Massagué, S. Blain, R. Lo (2000)
TGFβ Signaling in Growth Control, Cancer, and Heritable DisordersCell, 103
Agnieszka Gorska, R. Jensen, Y. Shyr, M. Aakre, N. Bhowmick, H. Moses (2003)
Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-beta receptor exhibit impaired mammary development and enhanced mammary tumor formation.The American journal of pathology, 163 4
Sheila Singh, C. Hawkins, I. Clarke, J. Squire, J. Bayani, T. Hide, R. Henkelman, M. Cusimano, M. Cusimano, P. Dirks (2004)
Identification of human brain tumour initiating cellsNature, 432
Yigong Shi, J. Massagué (2003)
Mechanisms of TGF-β Signaling from Cell Membrane to the NucleusCell, 113
A. Bellahcène, M. Kroll, F. Liebens, V. Castronovo (1996)
Bone sialoprotein expression in primary human breast cancer is associated with bone metastases developmentJournal of Bone and Mineral Research, 11
Bryan Zhao, F. Hoffmann (2006)
Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA.Molecular biology of the cell, 17 9
E. Canalis (2009)
Growth factor control of bone massJournal of Cellular Biochemistry, 108
Lorea Bueno, D. Alwis, C. Pitou, J. Yingling, M. Lahn, S. Glatt, I. Trocóniz (2008)
Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice.European journal of cancer, 44 1
R. Derynck, R. Akhurst (2007)
Differentiation plasticity regulated by TGF-β family proteins in development and diseaseNature Cell Biology, 9
C. Arteaga, Teresa Carty-Dugger, H. Moses, S. Hurd, J. Pietenpol (1993)
Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice.Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 4 3
Nilay Sethi, Xudong Dai, C. Winter, Yibin Kang (2011)
Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells.Cancer cell, 19 2
G. Balooch, M. Balooch, R. Nalla, Stephen Schilling, E. Filvaroff, G. Marshall, S. Marshall, R. Ritchie, R. Derynck, T. Alliston (2005)
TGF-beta regulates the mechanical properties and composition of bone matrix.Proceedings of the National Academy of Sciences of the United States of America, 102 52
J. Yingling, K. Blanchard, J. Sawyer (2004)
Development of TGF-β signalling inhibitors for cancer therapyNature Reviews Drug Discovery, 3
M. Travers, P. Barrett-Lee, U. Berger, Y. Luqmani, J. Gazet, T. Powles, R. Coombes (1988)
Growth factor expression in normal, benign, and malignant breast tissueBritish Medical Journal (Clinical research ed.), 296
GR Mundy (2002)
Metastasis to bone: causes, consequences and therapeutic opportunitiesNat Rev Canc, 2
G. Powell, J. Southby, J. Danks, R. Stillwell, J. Hayman, Michael Henderson, R. Bennett, T. Martin (1991)
Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites.Cancer research, 51 11
KS Mohammad, EG Stebbins, L Kingsley, PGJ Fournier, M Niewolna, CR McKenna, X Peng, L Higgins, D Wong, TA Guise (2008)
Combined transforming growth factor b receptor I kinase inhibitor and biphosphonates are additve to reduce breast cancer bone metastasesJ Bone Miner Res, 23
Qiqi Cui, S. Lim, Bryan Zhao, F. Hoffmann (2005)
Selective inhibition of TGF-β responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBPOncogene, 24
P. Siegel, Weiping Shu, J. Massagué (2003)
Mad Upregulation and Id2 Repression Accompany Transforming Growth Factor (TGF)-β-mediated Epithelial Cell Growth Suppression*Journal of Biological Chemistry, 278
N. Kohno, S. Kitazawa, Y. Sakoda, Y. Kanbara, Y. Furuya, O. Ohashi, R. Kitazawa (1994)
Parathyroid hormone-related protein in breast cancer tissues: Relationship between primary and metastatic sitesBreast Cancer, 1
N. Gaspar, Lingyun Li, A. Kapoun, S. Medicherla, M. Reddy, Georgia Li, G. O’Young, D. Quon, M. Henson, D. Damm, Gladys Muiru, Alison Murphy, L. Higgins, S. Chakravarty, Darren Wong (2007)
Inhibition of Transforming Growth Factor β Signaling Reduces Pancreatic Adenocarcinoma Growth and InvasivenessMolecular Pharmacology, 72
Yukimi Taniguchi, K. Kawano, T. Minowa, T. Sugino, Yu Shimojo, Y. Maitani (2010)
Enhanced antitumor efficacy of folate‐linked liposomal doxorubicin with TGF‐β type I receptor inhibitorCancer Science, 101
Mary Wu, C. Hill (2009)
Tgf-beta superfamily signaling in embryonic development and homeostasis.Developmental cell, 16 3
Yibin Kang, J. Massagué (2004)
Epithelial-Mesenchymal Transitions Twist in Development and MetastasisCell, 118
Sendurai Mani, Wenjun Guo, Mai-Jing Liao, E. Eaton, Ayyakkannu Ayyanan, A. Zhou, M. Brooks, Ferenc Reinhard, C. Zhang, M. Shipitsin, Lauren Campbell, K. Polyak, C. Brisken, Jing Yang, R. Weinberg (2008)
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem CellsCell, 133
A. Erlebacher, R. Derynck (1996)
Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotypeThe Journal of Cell Biology, 132
R. Kelly, J. Morris (2010)
Transforming growth factor-beta: A target for cancer therapyJournal of Immunotoxicology, 7
S. Sheen-Chen, Han-Shiang Chen, C. Sheen, H. Eng, Wei Chen (2001)
Serum Levels of Transforming Growth Factor β1 in Patients With Breast CancerArchives of Surgery, 136
S. Halder, R. Beauchamp, P. Datta (2005)
A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers.Neoplasia, 7 5
Michael Henderson, J. Danks, J. Moseley, J. Slavin, Toni Harris, Martina McKinlay, J. Hopper, T. Martin (2001)
Parathyroid hormone-related protein production by breast cancers, improved survival, and reduced bone metastases.Journal of the National Cancer Institute, 93 3
The FASEB Journal • Research Communication The activin A-follistatin system: potent regulator of human extracellular matrix mineralization
Jeong-Seok Nam, M. Terabe, M. Mamura, M. Kang, Helen Chae, C. Stuelten, Ethan Kohn, Binwu Tang, H. Sabzevari, M. Anver, Scott Lawrence, D. Danielpour, S. Lonning, J. Berzofsky, L. Wakefield (2008)
An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments.Cancer research, 68 10
H. Trachtman, F. Fervenza, D. Gipson, P. Heering, D. Jayne, H. Peters, S. Rota, G. Remuzzi, L. Rump, L. Sellin, Jeremy Heaton, J. Streisand, M. Hard, S. Ledbetter, F. Vincenti (2011)
A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosisKidney International, 79
Li Zhang, X. Hou, Shun Lu, H. Rao, J. Hou, R. Luo, He Huang, Hongyun Zhao, H. Jian, Zhiwei Chen, M. Liao, Xin Wang (2010)
Predictive significance of bone sialoprotein and osteopontin for bone metastases in resected Chinese non-small-cell lung cancer patients: a large cohort retrospective study.Lung cancer, 67 1
E. Pardali, M. Goumans, P. Dijke (2010)
Signaling by members of the TGF-beta family in vascular morphogenesis and disease.Trends in cell biology, 20 9
M. Deckers, Maarten Dinther, J. Buijs, I. Que, C. Löwik, G. Pluijm, P. Dijke (2006)
The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells.Cancer research, 66 4
P. Mancuso, D. Shalinsky, A. Calleri, J. Quarna, P. Antoniotti, I. Jilani, D. Hu-Lowe, X. Jiang, C. Gallo-Stampino, F. Bertolini (2009)
Evaluation of ALK-1 expression in circulating endothelial cells (CECs) as an exploratory biomarker for PF-03446962 undergoing phase I trial in cancer patients.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 27 15_suppl
U. Bogdahn, P. Hau, G. Stockhammer, N. Venkataramana, A. Mahapatra, A. Suri, A. Balasubramaniam, S. Nair, V. Oliushine, V. Parfenov, I. Poverennova, M. Zaaroor, P. Jachimczak, S. Ludwig, S. Schmaus, H. Heinrichs, K. Schlingensiepen (2010)
Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb studyNeuro-Oncology, 13
A. Bandyopadhyay, J. Agyin, Long Wang, Yuping Tang, Xiu-fen Lei, B. Story, J. Cornell, B. Pollock, G. Mundy, Luzhe Sun (2006)
Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor.Cancer research, 66 13
N. Gadir, D. Jackson, Evan Lee, D. Foster (2008)
Defective TGF-β signaling sensitizes human cancer cells to rapamycinOncogene, 27
S. Wojtowicz-Praga, U. Verma, L. Wakefield, J. Esteban, D. Hartmann, A. Mazumder (1996)
Modulation of B16 melanoma growth and metastasis by anti-transforming growth factor beta antibody and interleukin-2.Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy, 19 3
D. Melisi, S. Ishiyama, G. Sclabas, J. Fleming, Qianghua Xia, G. Tortora, J. Abbruzzese, P. Chiao (2008)
LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasisMolecular Cancer Therapeutics, 7
M. Al-Hajj, M. Wicha, Adalberto Benito-Hernández, S. Morrison, M. Clarke (2003)
Prospective identification of tumorigenic breast cancer cellsProceedings of the National Academy of Sciences of the United States of America, 100
M. Uhl, Steffen Aulwurm, J. Wischhusen, M. Weiler, J. Ma, R. Almirez, R. Mangadu, Yu-Wang Liu, M. Platten, U. Herrlinger, Alison Murphy, Darren Wong, W. Wick, L. Higgins, M. Weller (2004)
SD-208, a Novel Transforming Growth Factor β Receptor I Kinase Inhibitor, Inhibits Growth and Invasiveness and Enhances Immunogenicity of Murine and Human Glioma Cells In vitro and In vivoCancer Research, 64
J. Morris, G. Shapiro, A. Tan, D. Lawrence, T. Olencki, B. Dezube, F. Hsu, M. Reiss, J. Berzofsky (2008)
Phase I/II study of GC1008: A human anti-transforming growth factor-beta (TGF{beta}) monoclonal antibody (MAb) in patients with advanced malignant melanoma (MM) or renal cell carcinoma (RCC)Journal of Clinical Oncology, 26
G. Mundy, J. Edwards (2008)
PTH-related peptide (PTHrP) in hypercalcemia.Journal of the American Society of Nephrology : JASN, 19 4
J. Buijs, N. Henriquez, P. Overveld, G. Horst, I. Que, R. Schwaninger, C. Rentsch, P. Dijke, A. Cleton-Jansen, K. Driouch, R. Lidereau, R. Bachelier, S. Vukicevic, P. Clézardin, S. Papapoulos, M. Cecchini, C. Löwik, G. Pluijm (2007)
Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer.Cancer research, 67 18
V. Ivanović, N. Todorović-Raković, M. Demajo, Z. Nešković‐Konstantinović, V. Subota, Olivera Ivanisević-Milovanović, D. Nikolić‐Vukosavljević (2003)
Elevated plasma levels of transforming growth factor-beta 1 (TGF-beta 1) in patients with advanced breast cancer: association with disease progression.European journal of cancer, 39 4
S. Käkönen, K. Selander, J. Chirgwin, J. Yin, S. Burns, W. Rankin, B. Grubbs, M. Dallas, Yong Cui, T. Guise (2002)
Transforming Growth Factor-β Stimulates Parathyroid Hormone-related Protein and Osteolytic Metastases via Smad and Mitogen-activated Protein Kinase Signaling Pathways*The Journal of Biological Chemistry, 277
E. Suzuki, Samuel Kim, H. Cheung, M. Corbley, Xiamei Zhang, Lihong Sun, F. Shan, Juswinder Singh, Wen-Cherng Lee, S. Albelda, L. Ling (2007)
A Novel Small-Molecule Inhibitor of Transforming Growth Factor β Type I Receptor Kinase (SM16) Inhibits Murine Mesothelioma Tumor Growth In vivo and Prevents Tumor Recurrence after Surgical ResectionCancer Research, 67
M. Rausch, T. Hahn, Lalitha Ramanathapuram, D. Bradley-Dunlop, D. Mahadevan, Melania Mercado-Pimentel, Raymond Runyan, D. Besselsen, Xiamei Zhang, H. Cheung, Wen-Cherng Lee, L. Ling, E. Akporiaye (2009)
An orally active small molecule TGF-beta receptor I antagonist inhibits the growth of metastatic murine breast cancer.Anticancer research, 29 6
S. Seyedin, T. Thomas, A. Thompson, D. Rosen, K. Piez (1985)
Purification and characterization of two cartilage-inducing factors from bovine demineralized bone.Proceedings of the National Academy of Sciences of the United States of America, 82 8
R. Galvin, Cindy Gatlin, J. Horn, T. Fuson (1999)
TGF-beta enhances osteoclast differentiation in hematopoietic cell cultures stimulated with RANKL and M-CSF.Biochemical and biophysical research communications, 265 1
J Massague (2008)
TGFbeta in CancerCell, 134
J. Edwards, J. Nyman, S. Lwin, Megan Moore, Javier Esparza, E. O'Quinn, Andrew Hart, S. Biswas, Chetan Patil, S. Lonning, A. Mahadevan-Jansen, G. Mundy (2010)
Inhibition of TGF‐β signaling by 1D11 antibody treatment increases bone mass and quality in vivoJournal of Bone and Mineral Research, 25
M. Kissin, M.A Henderson, J. Danks, John Hayman, R. Bennett, Thomas Martin (1993)
Parathyroid hormone related protein in breast cancers of widely varying prognosis.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 19 2
S. Gorsch, V. Memoli, T. Stukel, L. Gold, B. Arrick (1992)
Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer.Cancer research, 52 24
J. Nemunaitis, J. Nemunaitis, M. Nemunaitis, N. Senzer, N. Senzer, P. Snitz, C. Bedell, Padmasini Kumar, B. Pappen, P. Maples, D. Shawler, H. Fakhrai (2009)
Phase II trial of Belagenpumatucel-L, a TGF-β2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patientsCancer Gene Therapy, 16
Borut Klopcic, T. Maass, E. Meyer, H. Lehr, D. Metzger, P. Chambon, A. Mann, M. Blessing (2007)
TGF-beta superfamily signaling is essential for tooth and hair morphogenesis and differentiation.European journal of cell biology, 86 11-12
M. Goumans, Gudrun Valdimarsdottir, S. Itoh, A. Rosendahl, P. Sideras, P. Dijke (2002)
Balancing the activation state of the endothelium via two distinct TGF‐β type I receptorsThe EMBO Journal, 21
G. Luo, C. Hofmann, A. Bronckers, M. Sohocko, A. Bradley, G. Karsenty (1995)
BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.Genes & development, 9 22
T. Hiraga, S. Kizaka-Kondoh, K. Hirota, M. Hiraoka, T. Yoneda (2007)
Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer.Cancer research, 67 9
A. Bandyopadhyay, Yong Zhu, M. Cibull, LiWei Bao, Changguo Chen, Luzhe Sun (1999)
A soluble transforming growth factor beta type III receptor suppresses tumorigenicity and metastasis of human breast cancer MDA-MB-231 cells.Cancer research, 59 19
M. Petersen, M. Thorikay, M. Deckers, M. Dinther, E. Grygielko, F. Gellibert, A. Gouville, S. Huet, P. Dijke, N. Laping (2008)
Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis.Kidney international, 73 6
T. Reya, S. Morrison, M. Clarke, I. Weissman (2001)
Stem cells, cancer, and cancer stem cellsNature, 414
W. Ishida, Y. Mori, G. Lakos, Lihong Sun, F. Shan, Scott Bowes, Serene Josiah, Wen-Cherng Lee, Juswinder Singh, L. Ling, J. Varga (2006)
Intracellular TGF-β Receptor Blockade Abrogates Smad-Dependent Fibroblast Activation In Vitro and In VivoJournal of Investigative Dermatology, 126
D. Bonafoux, Wen-Cherng Lee (2009)
Strategies for TGF-β modulation: a review of recent patentsExpert Opinion on Therapeutic Patents, 19
J. Buijs, C. Rentsch, G. Horst, P. Overveld, A. Wetterwald, R. Schwaninger, N. Henriquez, P. Dijke, F. Borovečki, R. Markwalder, G. Thalmann, S. Papapoulos, R. Pelger, S. Vukicevic, M. Cecchini, C. Löwik, G. Pluijm (2007)
BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo.The American journal of pathology, 171 3
J. Buijs, N. Henriquez, P. Overveld, G. Horst, P. Dijke, G. Pluijm (2007)
TGF-β and BMP7 interactions in tumour progression and bone metastasisClinical & Experimental Metastasis, 24
S. Hotte, E. Winquist, L. Stitt, Sylvia Wilson, A. Chambers (2002)
Plasma osteopontinCancer, 95
H. Ikushima, K. Miyazono (2010)
TGFβ signalling: a complex web in cancer progressionNature Reviews Cancer, 10
M. Cordeiro, P. Khaw (1999)
Human anti-transforming growth factor-beta2 antibody: a new glaucoma anti-scarring agent.Investigative ophthalmology & visual science, 40 10
M. Ruzek, M. Hawes, B. Pratt, J. McPherson, S. Ledbetter, S. Richards, R. Garman (2003)
Minimal Effects on Immune Parameters Following Chronic Anti-TGF-β Monoclonal Antibody Administration to Normal MiceImmunopharmacology and Immunotoxicology, 25
A. Bellahcène, V. Castronovo, K. Ogbureke, L. Fisher, N. Fedarko (2008)
Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancerNature Reviews Cancer, 8
P. Dijke, P. Dijke (2006)
Bone morphogenetic protein signal transduction in boneCurrent Medical Research and Opinion, 22
S. Tsang, A. Kung (2011)
Risk factors associated with 10-year risk of osteoporotic fractures in Hong Kong Southern Chinese men: a prospectvie study
G. Roodman (2004)
Mechanisms of bone metastasis.Discovery medicine, 4 22
K. Schlingensiepen, R. Schlingensiepen, A. Steinbrecher, P. Hau, U. Bogdahn, Birgit Fischer‐Blass, P. Jachimczak (2006)
Targeted tumor therapy with the TGF-β2 antisense compound AP 12009Cytokine & Growth Factor Reviews, 17
RE Coleman (1997)
1588Cancer, 80
Linda Yaswen, A. Kulkarni, T. Fredrickson, B. Mittleman, R. Schiffman, S. Payne, G. Longenecker, E. Mozes, S. Karlsson (1996)
Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse.Blood, 87 4
J. Iqbal, Li Sun, M. Zaidi (2009)
Coupling bone degradation to formationNature Medicine, 15
Bixiang Zhang, S. Halder, Sanguo Zhang, P. Datta (2009)
Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer.Cancer letters, 277 1
K. Janssens, P. Dijke, S. Janssens, W. Hul (2005)
Transforming Growth Factor- 1 to the Bone
N. Cheng, A. Chytil, Y. Shyr, A. Joly, H. Moses (2008)
Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion.Molecular cancer research : MCR, 6 10
J. Massagué (2000)
How cells read TGF-β signalsNature Reviews Molecular Cell Biology, 1
H. Fakhrai, JC Mantil, L. Liu, GL Nicholson, CS Murphy-Satter, J. Ruppert, DL Shawler (2006)
Phase I clinical trial of a TGF-β antisense-modified tumor cell vaccine in patients with advanced gliomaCancer Gene Therapy, 13
E. Wiercinska, H. Naber, E. Pardali, G. Pluijm, H. Dam, P. Dijke (2011)
The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model systemBreast Cancer Research and Treatment, 128
H. Fakhrai, O. Dorigo, D. Shawler, Hong Lin, D. Mercola, K. Black, I. Royston, R. Sobol (1996)
Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy.Proceedings of the National Academy of Sciences of the United States of America, 93 7
David Padua, X. Zhang, Qiongqing Wang, C. Nadal, W. Gerald, R. Gomis, J. Massagué (2008)
TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4Cell, 133
M. Karsdal, T. Andersen, L. Bonewald, C. Christiansen (2004)
Matrix metalloproteinases (MMPs) safeguard osteoblasts from apoptosis during transdifferentiation into osteocytes: MT1-MMP maintains osteocyte viability.DNA and cell biology, 23 3
S. Byfield, C. Major, N. Laping, A. Roberts (2004)
SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.Molecular pharmacology, 65 3
R. Derynck, R. Akhurst (2007)
Differentiation plasticity regulated by TGF-|[beta]| family proteins in development and diseaseNature, 9
Jeong-Seok Nam, M. Terabe, M. Kang, Helen Chae, Nga Voong, Yu-an Yang, A. Laurence, Aleksandra Michalowska, M. Mamura, S. Lonning, J. Berzofsky, L. Wakefield (2008)
Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17.Cancer research, 68 10
M. Shipitsin, Lauren Campbell, P. Argani, S. Weremowicz, Noga Bloushtain-Qimron, Jun Yao, T. Nikolskaya, T. Serebryiskaya, R. Beroukhim, Min Hu, M. Halushka, S. Sukumar, L. Parker, K. Anderson, L. Harris, J. Garber, A. Richardson, S. Schnitt, Y. Nikolsky, R. Gelman, K. Polyak (2007)
Molecular definition of breast tumor heterogeneity.Cancer cell, 11 3
R. Muraoka, Y. Koh, L. Roebuck, Melinda Sanders, Dana Brantley-Sieders, Agnieszka Gorska, Harold Moses, C. Arteaga (2003)
Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1Molecular and Cellular Biology, 23
I. Serganova, Ekaterina Moroz, J. Vider, G. Gogiberidze, Maxim Moroz, N. Pillarsetty, Michael Doubrovin, A. Minn, H. Thaler, J. Massagué, J. Gelovani, R. Blasberg (2009)
Multimodality imaging of TGFβ signaling in breast cancer metastasesThe FASEB Journal, 23
D Chen, M Zhao, GR Mundy (2004)
Bone morphogenetic proteinsGrowth Factors, 22
Yibin Kang, Wei He, Shaun Tulley, G. Gupta, I. Serganova, C. Chen, K. Manova-Todorova, R. Blasberg, W. Gerald, J. Massagué (2005)
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway.Proceedings of the National Academy of Sciences of the United States of America, 102 39
G. Mundy (2002)
Metastasis: Metastasis to bone: causes, consequences and therapeutic opportunitiesNature Reviews Cancer, 2
E. Calvo-Aller, J. Baselga, S. Glatt, A. Cleverly, M. Lahn, C. Arteaga, M. Rothenberg, M. Carducci (2008)
First human dose escalation study in patients with metastatic malignancies to determine safety and pharmacokinetics of LY2157299, a small molecule inhibitor of the transforming growth factor-beta receptor I kinaseJournal of Clinical Oncology, 26
H. Ikushima, A. Komuro, Kazunobu Isogaya, Masahiko Shinozaki, U. Hellman, K. Miyazawa, K. Miyazono (2008)
An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-β signallingThe EMBO Journal, 27
A. Kulkarni, C. Huh, D. Becker, A. Geiser, Marion Lyght, K. Flanders, A. Roberts, M. Sporn, Jerrold Ward, S. Karlsson (1993)
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.Proceedings of the National Academy of Sciences of the United States of America, 90
G. Blobe, W. Schiemann, H. Lodish (2000)
Role of transforming growth factor beta in human disease.The New England journal of medicine, 342 18
J. Won, H. Kim, E. Park, Y. Hong, S. Kim, Y. Yun (1999)
Tumorigenicity of mouse thymoma is suppressed by soluble type II transforming growth factor beta receptor therapy.Cancer research, 59 6
C. Bennett, E. Swayze (2010)
RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform.Annual review of pharmacology and toxicology, 50
J. Nemunaitis, R. Dillman, P. Schwarzenberger, N. Senzer, C. Cunningham, J. Cutler, A. Tong, Padmasini Kumar, B. Pappen, C. Hamilton, E. Devol, P. Maples, Lily Liu, T. Chamberlin, D. Shawler, H. Fakhrai (2006)
Phase II study of belagenpumatucel-L, a transforming growth factor beta-2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24 29
J. Massagué (2008)
TGFβ in CancerCell, 134
Rongrong Ge, Vaishali Rajeev, P. Ray, E. Lattime, S. Rittling, S. Medicherla, A. Protter, Alison Murphy, J. Chakravarty, S. Dugar, G. Schreiner, N. Barnard, M. Reiss (2006)
Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase In vivoClinical Cancer Research, 12
S. McMahon, M. Charbonneau, Sébastien Grandmont, D. Richard, C. Dubois (2006)
Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression.The Journal of biological chemistry, 281 34
M Eijken, S Swagemakers, M Koedam, C Steenbergen, P Derkx, AG Uitterlinden, PJ Spek, JA Visser, FH Jong, HA Pols, JP Leeuwen (2007)
The activin A-follistatin system: potent regulator of human extracellular matrix mineralizationFASEB J, 21
Y. Filyak, O. Filyak, R. Stoika (2007)
Transforming growth factor beta‐1 enhances cytotoxic effect of doxorubicin in human lung adenocarcinoma cells of A549 lineCell Biology International, 31
Lauren Dunn, K. Mohammad, Pierrick Fournier, C. McKenna, Holly Davis, M. Niewolna, X. Peng, J. Chirgwin, T. Guise (2009)
Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone MicroenvironmentPLoS ONE, 4
O. Shinto, M. Yashiro, T. Toyokawa, T. Nishii, R. Kaizaki, T. Matsuzaki, S. Noda, N. Kubo, Hiroaki Tanaka, Y. Doi, M. Ohira, K. Muguruma, T. Sawada, K. Hirakawa (2010)
Phosphorylated Smad2 in Advanced Stage Gastric CarcinomaBMC Cancer, 10
G. Prud’homme (2007)
Pathobiology of transforming growth factor β in cancer, fibrosis and immunologic disease, and therapeutic considerationsLaboratory Investigation, 87
L. Ricci-Vitiani, D. Lombardi, E. Pilozzi, M. Biffoni, M. Todaro, C. Peschle, R. Maria (2007)
Identification and expansion of human colon-cancer-initiating cellsNature, 445
E. Forrester, A. Chytil, Brian Bierie, M. Aakre, Agnieszka Gorska, A. Sharif-Afshar, W. Muller, H. Moses (2005)
Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis.Cancer research, 65 6
N. Laping, E. Grygielko, A. Mathur, S. Butter, J. Bomberger, C. Tweed, W. Martin, J. Fornwald, R. Lehr, J. Harling, L. Gaster, J. Callahan, B. Olson, Gene Sciences, Medicinal Chemistry (2002)
Inhibition of Transforming Growth Factor (TGF)- 1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF- Type I Receptor Kinase Activity: SB-431542
S. Ehata, A. Hanyu, M. Fujime, Yoko Katsuno, E. Fukunaga, K. Goto, Y. Ishikawa, K. Nomura, H. Yokoo, Toshiyuki Shimizu, E. Ogata, K. Miyazono, K. Shimizu, T. Imamura (2007)
Ki26894, a novel transforming growth factor‐β type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell lineCancer Science, 98
N. Bhowmick, A. Chytil, David Plieth, Agnieszka Gorska, N. Dumont, S. Shappell, M. Washington, E. Neilson, H. Moses (2004)
TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent EpitheliaScience, 303
P. Siegel, Weiping Shu, R. Cardiff, W. Muller, J. Massagué (2003)
Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis.Proceedings of the National Academy of Sciences of the United States of America, 100 14
Yi Tang, Xiangwei Wu, Weiqi Lei, Lijuan Pang, C. Wan, Zhenqi Shi, Ling Zhao, T. Nagy, Xinyu Peng, Junbo Hu, Xu Feng, W. Hul, M. Wan, Xu Cao (2009)
TGF-β1-induced Migration of Bone Mesenchymal Stem Cells Couples Bone Resorption and FormationNature medicine, 15
J. Southby, Kissin Mw, J. Danks, J. Hayman, J. Moseley, Michael Henderson, R. Bennett, T. Martin (1990)
Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer.Cancer research, 50 23
J. Yin, K. Selander, J. Chirgwin, M. Dallas, B. Grubbs, R. Wieser, J. Massagué, G. Mundy, T. Guise (1999)
TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development.The Journal of clinical investigation, 103 2
R. Coleman (1997)
Skeletal complications of malignancyCancer, 80
A. Jemal, F. Bray, Melissa Center, J. Ferlay, Elizabeth Ward, David Forman (2011)
Global Cancer Statistics
M. Henderson, J. Danks, J. Slavin, G. Byrnes, P. Choong, J. Spillane, J. Hopper, T. Martin (2006)
Parathyroid hormone-related protein localization in breast cancers predict improved prognosis.Cancer research, 66 4
J. Massagué, Ye-Guang Chen (2000)
Controlling TGF-β signalingGenes & Development
P. Keown, Arnold Greenbergt (1993)
Immunocytochemical Localization ofSecreted Transforming Growth Factor- 1totheAdvancing EdgesofPrimary TumorsandtoLymphNode Metastases ofHumanMammaryCarcinoma
R. Muraoka, N. Dumont, C. Ritter, T. Dugger, D. Brantley, Jin Chen, Evangeline Easterly, L. Roebuck, S. Ryan, P. Gotwals, V. Koteliansky, C. Arteaga (2002)
Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastasesJournal of Clinical Investigation, 109
J. Dasch, D. Pace, W. Waegell, D. Inenaga, L. Ellingsworth (1989)
Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification.Journal of immunology, 142 5
R. Muraoka-Cook, H. Kurokawa, Y. Koh, J Forbes, L. Roebuck, M. Barcellos-Hoff, S. Moody, Lewis Chodosh, C. Arteaga (2004)
Conditional Overexpression of Active Transforming Growth Factor β1 In vivo Accelerates Metastases of Transgenic Mammary TumorsCancer Research, 64
A. Tan, G. Alexe, M. Reiss (2009)
Transforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer?Breast cancer research and treatment, 115 3
N. Bundred, J. Morrison, W. Ratcliffe, J. Ratcliffe, Jane Warwick, Rosemary Walker (1992)
Parathyroid hormone related protein and skeletal morbidity in breast cancer.European journal of cancer, 28 2-3
A. Collins, P. Berry, Catherine Hyde, M. Stower, N. Maitland (2005)
Prospective identification of tumorigenic prostate cancer stem cells.Cancer research, 65 23
S. Crooke (2004)
Progress in antisense technology.Annual review of medicine, 55
J. Jong, P. Diest, P. Valk, J. Baak (1998)
Expression of growth factors, growth‐inhibiting factors, and their receptors in invasive breast cancer. II: Correlations with proliferation and angiogenesisThe Journal of Pathology, 184
Sheng-Bin Peng, Lei Yan, Xiaoling Xia, S. Watkins, H. Brooks, D. Beight, D. Herron, Michael Jones, J. Lampe, W. Mcmillen, N. Mort, J. Sawyer, J. Yingling (2005)
Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition.Biochemistry, 44 7
J. Buijs, C. Kuijpers, G. Pluijm (2010)
Targeted therapy options for treatment of bone metastases; beyond bisphosphonates.Current pharmaceutical design, 16 27
Transforming Growth Factor (cid:2) -Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth (cid:1) †
Yibin Kang, P. Siegel, Weiping Shu, M. Drobnjak, Sanna Kakonen, C. Cordon-Cardo, T. Guise, J. Massagué (2003)
A multigenic program mediating breast cancer metastasis to bone.Cancer cell, 3 6
M. Petersen, E. Pardali, G. Horst, H. Cheung, Christel van, D. Hoogen, G. Pluijm, P. Dijke (2010)
Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesisOncogene, 29
GD Roodman (2004)
Mechanisms of bone metastasisNew Engl J Med, 350
S Biswas, M Guix, C Rinehart, TC Dugger, A Chytil, HL Moses, ML Freeman, CL Arteaga (2007)
Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progressionJ Clin Investig, 117
G. Subramanian, R. Schwarz, L. Higgins, G. Mcenroe, S. Chakravarty, S. Dugar, M. Reiss (2004)
Targeting Endogenous Transforming Growth Factor β Receptor Signaling in SMAD4-Deficient Human Pancreatic Carcinoma Cells Inhibits Their Invasive Phenotype 1Cancer Research, 64
V. Hengst, V. Hengst, C. Oussoren, T. Kissel, Gert Storm (2007)
Bone targeting potential of bisphosphonate-targeted liposomes. Preparation, characterization and hydroxyapatite binding in vitro.International journal of pharmaceutics, 331 2
A. Grau, W. Wen, Denise Ramroopsingh, Yu-Tang Gao, Jinghuan Zi, Q. Cai, X. Shu, W. Zheng (2008)
Circulating transforming growth factor-β-1 and breast cancer prognosis: results from the Shanghai Breast Cancer StudyBreast Cancer Research and Treatment, 112
SJ Hotte, EW Winquist, L Stitt, SM Wilson, AF Chambers (2002)
Plasma osteopontin: associations with survival and metastasis to bone in men with hormone-refractory prostate carcinomaCancer, 95
M. Shull, I. Ormsby, A. Kier, S. Pawlowski, R. Diebold, M. Yin, Ruth Allen, C. Sidman, G. Proetzel, D. Calvin, Nikki Annunziata, T. Doetschman (1992)
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory diseaseNature, 359
PM Siegel (2003)
8430Proc Natl Acad Sci USA, 100
M. Buck, P. Fritz, J. Dippon, G. Zugmaier, C. Knabbe (2004)
Prognostic Significance of Transforming Growth Factor β Receptor II in Estrogen Receptor-Negative Breast Cancer PatientsClinical Cancer Research, 10
T. Watabe, A. Nishihara, Koichi Mishima, J. Yamashita, K. Shimizu, K. Miyazawa, S. Nishikawa, K. Miyazono (2003)
TGF-β receptor kinase inhibitor enhances growth and integrity of embryonic stem cell–derived endothelial cellsThe Journal of Cell Biology, 163
J. Brown, W. Wilson (2004)
Exploiting tumour hypoxia in cancer treatmentNature Reviews Cancer, 4
Xin Lu, C. Yan, Min Yuan, Yong Wei, G. Hu, Yibin Kang (2010)
In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer.Cancer research, 70 10
J. Sawyer, D. Beight, Karen Britt, Bryan Anderson, R. Campbell, T. Goodson, D. Herron, Hong‐yu Li, W. Mcmillen, N. Mort, S. Parsons, Edward Smith, Jill Wagner, Lei Yan, Faming Zhang, J. Yingling (2004)
Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.Bioorganic & medicinal chemistry letters, 14 13
T. Guise (2009)
Breaking down bone: new insight into site-specific mechanisms of breast cancer osteolysis mediated by metalloproteinases.Genes & development, 23 18
Yu-an Yang, O. Dukhanina, Binwu Tang, M. Mamura, J. Letterio, Jennifer Macgregor, S. Patel, S. Khozin, Zi-yao Liu, Jeffrey Green, M. Anver, G. Merlino, L. Wakefield (2002)
Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects.The Journal of clinical investigation, 109 12
J Massague, YG Chen (2000)
Controlling TGF-beta signalingGene Dev, 14
P. Hau, P. Jachimczak, R. Schlingensiepen, F. Schulmeyer, T. Jauch, A. Steinbrecher, A. Brawanski, M. Proescholdt, J. Schlaier, J. Buchroithner, J. Pichler, G. Wurm, M. Mehdorn, R. Strege, G. Schuierer, V. Villarrubia, F. Fellner, O. Jansen, T. Straube, V. Nohria, M. Goldbrunner, M. Kunst, S. Schmaus, G. Stauder, U. Bogdahn, K. Schlingensiepen (2007)
Inhibition of TGF-β2 with AP 12009 in Recurrent Malignant Gliomas: From Preclinical to Phase I/II StudiesOligonucleotides, 17
Xin Lu, Qiongqing Wang, G. Hu, C. Poznak, M. Fleisher, M. Reiss, J. Massagué, Yibin Kang (2009)
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis.Genes & development, 23 16
G. Lee, J. Hong, Thomas Mueller, J. Watson, C. Kwak, Youn Sheen, Dae‐Kee Kim, Seong-Jin Kim, I. Kim (2008)
Effect of IN-1130, a small molecule inhibitor of transforming growth factor-beta type I receptor/activin receptor-like kinase-5, on prostate cancer cells.The Journal of urology, 180 6
T. Guise, K. Mohammad, G. Clines, E. Stebbins, Darren Wong, L. Higgins, R. Vessella, E. Corey, S. Padalecki, L. Suva, J. Chirgwin (2006)
Basic Mechanisms Responsible for Osteolytic and Osteoblastic Bone MetastasesClinical Cancer Research, 12
R. Muraoka-Cook, Incheol Shin, Jae Yi, Evangeline Easterly, M. Barcellos-Hoff, J. Yingling, Roy Zent, C. Arteaga (2006)
Activated type I TGFβ receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progressionOncogene, 25
Xin-Hua Feng, R. Derynck (2005)
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADSAnnual Review of Cell and Developmental Biology, 21
Jeong-Seok Nam, Adam Suchar, M. Kang, C. Stuelten, Binwu Tang, Aleksandra Michalowska, L. Fisher, N. Fedarko, Alka Jain, J. Pinkas, S. Lonning, L. Wakefield (2006)
Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer.Cancer research, 66 12
C. Arteaga, S. Hurd, A. Winnier, M Johnson, B Fendly, J Forbes (1993)
Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.The Journal of clinical investigation, 92 6
R. Pearsall, E. Canalis, Milton Cornwall-Brady, K. Underwood, Brendan Haigis, J. Ucran, Ravindra Kumar, Eileen Pobre, A. Grinberg, E. Werner, V. Glatt, L. Stadmeyer, Deanna Smith, J. Seehra, M. Bouxsein (2008)
A soluble activin Type IIA receptor induces bone formation and improves skeletal integrityProceedings of the National Academy of Sciences, 105
SM Gorsch (1992)
6949Canc Res, 52
P. Dijke, H. Arthur (2007)
Extracellular control of TGFβ signalling in vascular development and diseaseNature Reviews Molecular Cell Biology, 8
Rachel Thomas, T. Guise, J. Yin, J. Elliott, N. Horwood, T. Martin, M. Gillespie (1999)
Breast Cancer Cells Interact with Osteoblasts to Support Osteoclast Formation1.Endocrinology, 140 10
JS de Jong (1998)
53J Pathol, 184
V. Ganapathy, Rongrong Ge, A. Grazioli, W. Xie, Whitney Banach-Petrosky, Yibin Kang, S. Lonning, J. McPherson, J. Yingling, S. Biswas, G. Mundy, M. Reiss (2010)
Targeting the Transforming Growth Factor-β pathway inhibits human basal-like breast cancer metastasisMolecular Cancer, 9
C. Hoogen, G. Horst, H. Cheung, J. Buijs, J. Lippitt, Natalia Guzmán-Ramírez, F. Hamdy, C. Eaton, G. Thalmann, M. Cecchini, R. Pelger, G. Pluijm (2010)
High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer.Cancer research, 70 12
K. Mohammad, Carol Chen, G. Balooch, E. Stebbins, C. McKenna, Holly Davis, M. Niewolna, Hong Xiang, Peng, Daniel Nguyen, S. Ionova-Martin, John Bracey, William Hogue, Darren Wong, R. Ritchie, L. Suva, R. Derynck, T. Guise, T. Alliston, J. Calbet (2009)
Pharmacologic Inhibition of the TGF-β Type I Receptor Kinase Has Anabolic and Anti-Catabolic Effects on BonePLoS ONE, 4
S. Maeda, M. Hayashi, S. Komiya, T. Imamura, K. Miyazono (2004)
Endogenous TGF‐β signaling suppresses maturation of osteoblastic mesenchymal cellsThe EMBO Journal, 23
R. Derynck, Ying Zhang (2003)
Smad-dependent and Smad-independent pathways in TGF-β family signallingNature, 425
Y Tang, X Wu, W Lei, L Pang, C Wan, Z Shi, L Zhao, TR Nagy, X Peng, J Hu, X Feng, W Hul, M Wan, X Cao (2009)
TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formationNat Med, 15
D. Siriwardena, P. Khaw, A. King, M. Donaldson, B. Overton, C. Migdal, M. Cordeiro (2002)
Human antitransforming growth factor beta(2) monoclonal antibody--a new modulator of wound healing in trabeculectomy: a randomized placebo controlled clinical study.Ophthalmology, 109 3
S. Byfield, A. Roberts (2004)
Lateral signaling enhances TGF-β response complexityTrends in Cell Biology, 14
A. Lenferink, J. Magoon, M. Pepin, A. Guimond, M. O’Connor-McCourt (2003)
Expression of TGF‐β type II receptor antisense RNA impairs TGF‐β signaling in vitro and promotes mammary gland differentiation in vivoInternational Journal of Cancer, 107
Kai Fu, M. Corbley, Lihong Sun, Jessica Friedman, F. Shan, James Papadatos, D. Costa, Frank Lutterodt, Harry Sweigard, Scott Bowes, Michael Choi, P. Boriack-Sjodin, Robert Arduini, Dongyu Sun, Miki Newman, Xiamei Zhang, Jonathan Mead, Claudio Chuaqui, H. Cheung, Xin Zhang, M. Cornebise, Mary Carter, Serene Josiah, Juswinder Singh, Wen-Cherng Lee, A. Gill, L. Ling (2008)
SM16, an Orally Active TGF-&bgr; Type I Receptor Inhibitor Prevents Myofibroblast Induction and Vascular Fibrosis in the Rat Carotid Injury ModelArteriosclerosis, Thrombosis, and Vascular Biology, 28
AC Daly (2008)
6889Mol Cell Biol, 28
J. Thiery, J. Thiery, H. Acloque, R. Huang, R. Huang, M. Nieto (2009)
Epithelial-Mesenchymal Transitions in Development and DiseaseCell, 139
T. Alliston, L. Choy, P. Ducy, G. Karsenty, R. Derynck (2001)
TGF‐β‐induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiationThe EMBO Journal, 20
O. Gautschi, S. Frey, R. Zellweger (2007)
BONE MORPHOGENETIC PROTEINS IN CLINICAL APPLICATIONSANZ Journal of Surgery, 77
Breast cancer is the most prevalent cancer among females worldwide. It has long been known that cancers preferentially metastasize to particular organs, and bone metastases occur in ∼70% of patients with advanced breast cancer. Breast cancer bone metastases are predominantly osteolytic and accompanied by bone destruction, bone fractures, pain, and hypercalcemia, causing severe morbidity and hospitalization. In the bone matrix, transforming growth factor-β (TGF-β) is one of the most abundant growth factors, which is released in active form upon tumor-induced osteoclastic bone resorption. TGF-β, in turn, stimulates bone metastatic cells to secrete factors that further drive osteolytic destruction of the bone adjacent to the tumor, categorizing TGF-β as a crucial factor responsible for driving the feed-forward vicious cycle of cancer growth in bone. Moreover, TGF-β activates epithelial-to-mesenchymal transition, increases tumor cell invasiveness and angiogenesis and induces immunosuppression. Blocking the TGF-β signaling pathway to interrupt this vicious cycle between breast cancer and bone offers a promising target for therapeutic intervention to decrease skeletal metastasis. This review will describe the role of TGF-β in breast cancer and bone metastasis, and pre-clinical and clinical data will be evaluated for the potential use of TGF-β inhibitors in clinical practice to treat breast cancer bone metastases.
Cancer Microenvironment – Springer Journals
Published: Jul 12, 2011
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