Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Herrath, L. Harrison (2003)
Regulatory lymphocytes: Antigen-induced regulatory T cells in autoimmunityNature Reviews Immunology, 3
T. Whiteside (2004)
Down-regulation of ζ-chain expression in T cells: a biomarker of prognosis in cancer?Cancer Immunology, Immunotherapy, 53
E. Jäger, J. Karbach, S. Gnjatic, A. Neumann, A. Bender, D. Valmori, M. Ayyoub, E. Ritter, G. Ritter, D. Jäger, D. Panicali, E. Hoffman, L. Pan, H. Oettgen, L. Old, A. Knuth (2006)
Recombinant vaccinia/fowlpox NY-ESO-1 vaccines induce both humoral and cellular NY-ESO-1-specific immune responses in cancer patientsProceedings of the National Academy of Sciences, 103
R. Steinman, I. Mellman (2004)
Immunotherapy: Bewitched, Bothered, and Bewildered No MoreScience, 305
M. Ahmadzadeh, S. Rosenberg (2005)
TGF-beta 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells.Journal of immunology, 174 9
K. Sugamura, H. Asao, M. Kondo, N. Tanaka, N. Ishii, K. Ohbo, M. Nakamura, T. Takeshita (1996)
The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID.Annual review of immunology, 14
E. Sato, S. Olson, Jiyoung Ahn, B. Bundy, H. Nishikawa, F. Qian, A. Jungbluth, D. Frosina, S. Gnjatic, C. Ambrosone, J. Kepner, Tosin Odunsi, G. Ritter, S. Lele, Yao-Tseng Chen, H. Ohtani, L. Old, K. Odunsi (2005)
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.Proceedings of the National Academy of Sciences of the United States of America, 102 51
W. Rao, J. Hales, R. Camp (2000)
Potent Costimulation of Effector T Lymphocytes by Human Collagen Type I1The Journal of Immunology, 165
M. Tomlinson, Victoria Heath, C. Turck, S. Watson, A. Weiss (2004)
SHIP Family Inositol Phosphatases Interact with and Negatively Regulate the Tec Tyrosine Kinase*Journal of Biological Chemistry, 279
D. Pilling, A. Akbar, J. Girdlestone, C. Orteu, N. Borthwick, N. Amft, D. Scheel-Toellner, C. Buckley, M. Salmon (1999)
Interferon‐β mediates stromal cell rescue of T cells from apoptosisEuropean Journal of Immunology, 29
L. Berg, L. Finkelstein, J. Lucas, P. Schwartzberg (2005)
Tec family kinases in T lymphocyte development and function.Annual review of immunology, 23
E. Ayroldi, O. Zollo, L. Cannarile, F. Adamio, U. Grohmann, D. Delfino, C. Riccardi (1998)
Interleukin-6 (IL-6) prevents activation-induced cell death: IL-2-independent inhibition of Fas/fasL expression and cell death.Blood, 92 11
Sue‐Yun Hwang, Ju-Young Kim, Kyoung-Woon Kim, Mi-Kyung Park, Youngmee Moon, Wan-Uk Kim, Ho‐Youn Kim (2004)
IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathwaysArthritis Research & Therapy, 6
A. Filer, Greg Parsonage, Emily Smith, Chloe Osborne, A. Thomas, S. Curnow, G. Rainger, K. Raza, G. Nash, J. Lord, M. Salmon, C. Buckley (2006)
Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils.Arthritis and rheumatism, 54 7
Daniel Barber, E. Wherry, D. Masopust, Baogong Zhu, James Allison, Arlene Sharpe, Gordon Freeman, R. Ahmed (2006)
Restoring function in exhausted CD8 T cells during chronic viral infectionNature, 439
CH Chen (2003)
10.1084/jem.20021170J Exp Med, 197
E. Shevach (2009)
Mechanisms of foxp3+ T regulatory cell-mediated suppression.Immunity, 30 5
K. Boniface, K. Bak-Jensen, Ying Li, W. Blumenschein, M. McGeachy, T. Mcclanahan, Brent McKenzie, R. Kastelein, D. Cua, R. Malefyt (2009)
Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signalingThe Journal of Experimental Medicine, 206
A. Sturm, K. Krivacic, C. Fiocchi, A. Levine (2004)
Dual Function of the Extracellular Matrix: Stimulatory for Cell Cycle Progression of Naive T Cells and Antiapoptotic for Tissue-Derived Memory T Cells1The Journal of Immunology, 173
Raji Nair, Y. Jong, S. Jones, Atima Sharma, E. Mathiowitz, N. Egilmez (2006)
IL-12 + GM-CSF Microsphere Therapy Induces Eradication of Advanced Spontaneous Tumors in her-2/neu Transgenic Mice But Fails to Achieve Long-Term Cure Due to the Inability to Maintain Effector T-Cell ActivityJournal of Immunotherapy, 29
L. Broderick, S. Yokota, J. Reineke, E. Mathiowitz, C. Stewart, M. Barcos, R. Kelleher, R. Bankert (2005)
Human CD4+ Effector Memory T Cells Persisting in the Microenvironment of Lung Cancer Xenografts Are Activated by Local Delivery of IL-12 to Proliferate, Produce IFN-γ, and Eradicate Tumor Cells1The Journal of Immunology, 174
M. Haniffa, Xiao‐nong Wang, U. Holtick, M. Rae, J. Isaacs, A. Dickinson, C. Hilkens, M. Collin (2007)
Adult Human Fibroblasts Are Potent Immunoregulatory Cells and Functionally Equivalent to Mesenchymal Stem Cells1The Journal of Immunology, 179
T. Yarovinsky, G. Hunninghake (2001)
Lung fibroblasts inhibit activation-induced death of T cells through PGE(2)-dependent mechanisms.American journal of physiology. Lung cellular and molecular physiology, 281 5
R. Weil, A. Israël (2006)
Deciphering the pathway from the TCR to NF-κBCell Death and Differentiation, 13
E. Jones, S. Kinsey, A. English, Richard Jones, Liz Straszynski, D. Meredith, A. Markham, A. Jack, P. Emery, D. Mcgonagle (2002)
Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells.Arthritis and rheumatism, 46 12
A. Kulkarni, C. Huh, D. Becker, A. Geiser, Marion Lyght, K. Flanders, A. Roberts, M. Sporn, Jerrold Ward, S. Karlsson (1993)
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.Proceedings of the National Academy of Sciences of the United States of America, 90
B. Spörri, M. Bickel, A. Limat, E. Waelti, T. Hunziker, U. Wiesmann (1997)
Autologous Versus Allogeneic T Cell-Stimulated IL-6 Production by Dermal FibroblastsInflammation, 21
J. Bach (2003)
Regulatory T cells under scrutinyNature Reviews Immunology, 3
L. Shultz, F. Ishikawa, D. Greiner (2007)
Humanized mice in translational biomedical researchNature Reviews Immunology, 7
J. Sathish, G. Dolton, F. Leroy, R. Matthews (2007)
Loss of Src Homology Region 2 Domain-Containing Protein Tyrosine Phosphatase-1 Increases CD8+ T Cell-APC Conjugate Formation and Is Associated with Enhanced In Vivo CTL Function1The Journal of Immunology, 178
P. Miossec, T. Korn, V. Kuchroo (2009)
Interleukin-17 and type 17 helper T cells.The New England journal of medicine, 361 9
H. Waldmann, S. Cobbold (2009)
Regulatory T cells: context matters.Immunity, 30 5
M. Ahmadzadeh, S. Rosenberg (2005)
TGF-β1 Attenuates the Acquisition and Expression of Effector Function by Tumor Antigen-Specific Human Memory CD8 T CellsThe Journal of Immunology, 174
M. Levings, R. Sangregorio, M. Roncarolo (2001)
Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of FunctionThe Journal of Experimental Medicine, 193
Alexander Pope, Bayar Hoffmann, Richard Thimmapaya, Hongtao Georganas, Harris Liu, Perlman (2013)
Regulation of Il-6 and Il-8 Expression In
K. Thiele, D. Riemann, A. Santos, J. Langner, A. Kehlen (2000)
Cell-cell contact of human T cells with fibroblasts changes lymphocytic mRNA expression: increased mRNA expression of interleukin-17 and interleukin-17 receptor.European cytokine network, 11 1
M. Simpson-Abelson, Gregory Sonnenberg, H. Takita, S. Yokota, T. Conway, R. Kelleher, L. Shultz, M. Barcos, R. Bankert (2008)
Long-Term Engraftment and Expansion of Tumor-Derived Memory T Cells Following the Implantation of Non-Disrupted Pieces of Human Lung Tumor into NOD-scid IL2Rγnull Mice1The Journal of Immunology, 180
S. Hugues, L. Fetler, L. Bonifaz, J. Helft, F. Amblard, S. Amigorena (2004)
Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunityNature Immunology, 5
E. Shevach (2002)
CD4+CD25+ suppressor T cells: more questions than answersNature Reviews Immunology, 2
R. Bankert, N. Egilmez, S. Hess (2001)
Human-SCID mouse chimeric models for the evaluation of anti-cancer therapies.Trends in immunology, 22 7
I. Pinchuk, J. Saada, E. Beswick, Gushyalatha Boya, Sumin Qiu, R. Mifflin, G. Raju, V. Reyes, D. Powell (2008)
PD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4+ T-cell activity.Gastroenterology, 135 4
R. Kalluri, M. Zeisberg (2006)
Fibroblasts in cancerNature Reviews Cancer, 6
L. Broderick, S. Brooks, H. Takita, A. Baer, J. Bernstein, R. Bankert (2006)
IL-12 reverses anergy to T cell receptor triggering in human lung tumor-associated memory T cells.Clinical immunology, 118 2-3
G. Murugaiyan, B. Saha (2009)
Protumor vs Antitumor Functions of IL-171The Journal of Immunology, 183
K. English, F. Barry, C. Field-Corbett, B. Mahon (2007)
IFN-gamma and TNF-alpha differentially regulate immunomodulation by murine mesenchymal stem cells.Immunology letters, 110 2
B. Olenchock, R. Guo, J. Carpenter, M. Jordan, M. Topham, G. Koretzky, X. Zhong (2006)
Disruption of diacylglycerol metabolism impairs the induction of T cell anergyNature Immunology, 7
W. Zou (2005)
Immunosuppressive networks in the tumour environment and their therapeutic relevanceNature Reviews Cancer, 5
M. Cook (2006)
The significance of inflammation and regression in melanomaVirchows Archiv A, 420
J. Chemnitz, R. Parry, K. Nichols, C. June, J. Riley (2004)
SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation1The Journal of Immunology, 173
(1992)
An analysis of prognostic factors in 8500 patients with cutaneous melanoma
P. Bousso, E. Robey (2004)
Dynamic behavior of T cells and thymocytes in lymphoid organs as revealed by two-photon microscopy.Immunity, 21 3
Y. Miyahara, K. Odunsi, Wenhao Chen, Guangyong Peng, Junko Matsuzaki, Rong-Fu Wang (2008)
Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancerProceedings of the National Academy of Sciences, 105
Ming Li, Y. Wan, Shomyseh Sanjabi, A. Robertson, R. Flavell (2006)
Transforming growth factor-beta regulation of immune responses.Annual review of immunology, 24
Sang-Keun Lee, Sam-Hwa Seo, Byoung-Soo Kim, Chang‐Deok Kim, Jeung-Hoon Lee, Jung-Soo Kang, P. Maeng, Jong-Soon Lim (2005)
IFN-gamma regulates the expression of B7-H1 in dermal fibroblast cells.Journal of dermatological science, 40 2
Ilona Kryczek, M. Banerjee, P. Cheng, Linhua Vatan, Wojciech Szeliga, Shuang Wei, E. Huang, Emily Finlayson, D. Simeone, T. Welling, A. Chang, G. Coukos, Rebecca Liu, W. Zou (2009)
Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments.Blood, 114 6
M. Markiewicz, Erica Wise, Z. Buchwald, Elizabeth Cheney, T. Hansen, A. Suri, S. Cemerski, P. Allen, A. Shaw (2009)
IL-12 Enhances CTL Synapse Formation and Induces Self-Reactivity1The Journal of Immunology, 182
S. Leivonen, V. Kähäri (2007)
Transforming growth factor-beta signaling in cancer invasion and metastasis.International journal of cancer, 121 10
E. Gilboa (2004)
The promise of cancer vaccinesNature Reviews Cancer, 4
M. Kilinc, K. Aulakh, Raji Nair, S. Jones, P. Alard, M. Kosiewicz, N. Egilmez (2006)
Reversing Tumor Immune Suppression with Intratumoral IL-12: Activation of Tumor-Associated T Effector/Memory Cells, Induction of T Suppressor Apoptosis, and Infiltration of CD8+ T Effectors1The Journal of Immunology, 177
Jae-Kwang Yoo, Jae-Ho Cho, Seung Lee, Y. Sung (2002)
IL-12 Provides Proliferation and Survival Signals to Murine CD4+ T Cells Through Phosphatidylinositol 3-Kinase/Akt Signaling Pathway1The Journal of Immunology, 169
A. Kosugi, Junko Sakakura, Koubun Yasuda, M. Ogata, T. Hamaoka (2001)
Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts.Immunity, 14 6
F. Strutz, H. Okada, C. Lo, T. Danoff, Robert Carone, J. Tomaszewski, E. Neilson (1995)
Identification and characterization of a fibroblast marker: FSP1The Journal of Cell Biology, 130
T. Tatsumi, T. Takehara, S. Yamaguchi, A. Sasakawa, T. Miyagi, M. Jinushi, R. Sakamori, K. Kohga, A. Uemura, K. Ohkawa, W. Storkus, N. Hayashi (2007)
Injection of IL-12 gene-transduced dendritic cells into mouse liver tumor lesions activates both innate and acquired immunityGene Therapy, 14
C. Melief, RenéE.M. Toes, J. Medema, S. Burg, F. Ossendorp, R. Offringa (2000)
Strategies for immunotherapy of cancer.Advances in immunology, 75
KJ Wood, S Sakaguchi (2003)
Regulatory T cells in transplantation toleranceNat Rev Immunol, 3
S. Gaffen (2009)
Structure and signalling in the IL-17 receptor familyNature Reviews Immunology, 9
N. Egilmez, S. Hess, Fangan Chen, H. Takita, T. Conway, R. Bankert (2002)
Human CD4+ effector T cells mediate indirect interleukin-12- and interferon-gamma-dependent suppression of autologous HLA-negative lung tumor xenografts in severe combined immunodeficient mice.Cancer research, 62 9
T. Nanki, K. Nagasaka, K. Hayashida, Y. Saita, N. Miyasaka (2001)
Chemokines Regulate IL-6 and IL-8 Production by Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis1The Journal of Immunology, 167
M. Colombo, G. Trinchieri (2002)
Interleukin-12 in anti-tumor immunity and immunotherapy.Cytokine & growth factor reviews, 13 2
C. Baglole, D. Ray, S. Bernstein, S. Feldon, Terry Smith, P. Sime, R. Phipps (2006)
More Than Structural Cells, Fibroblasts Create and Orchestrate the Tumor MicroenvironmentImmunological Investigations, 35
J. Letterio, A. Roberts (1998)
Regulation of immune responses by TGF-beta.Annual review of immunology, 16
S. Williams, Fang-An Chen, H. Kida, S. Yokata, K. Miya, Motohisa Kato, M. Barcos, H. Wang, T. Alosco, T. Umemoto, B. Croy, E. Repasky, R. Bankert (1996)
Engraftment of human tumor-infiltrating lymphocytes and the production of anti-tumor antibodies in SCID mice.Journal of immunology, 156 5
L. Broderick, R. Bankert (2006)
Membrane-Associated TGF-β1 Inhibits Human Memory T Cell Signaling in Malignant and Nonmalignant Inflammatory Microenvironments1The Journal of Immunology, 177
L. Coussens, Z. Werb (2002)
Inflammation and cancerNature, 420
C. Weaver, R. Hatton, Paul Mangan, L. Harrington (2007)
IL-17 family cytokines and the expanding diversity of effector T cell lineages.Annual review of immunology, 25
L. Shultz, Todd Pearson, Marie King, L. Giassi, Lisa Carney, B. Gott, B. Lyons, A. Rossini, D. Greiner (2007)
Humanized NOD/LtSz‐scid IL2 Receptor Common Gamma Chain Knockout Mice in Diabetes ResearchAnnals of the New York Academy of Sciences, 1103
K. Odunsi, A. Jungbluth, E. Stockert, F. Qian, S. Gnjatic, J. Tammela, M. Intengan, A. Beck, B. Keitz, Darren Santiago, B. Williamson, M. Scanlan, G. Ritter, Yao-Tseng Chen, D. Driscoll, A. Sood, S. Lele, L. Old (2003)
NY-ESO-1 and LAGE-1 cancer-testis antigens are potential targets for immunotherapy in epithelial ovarian cancer.Cancer research, 63 18
A. Nel (2002)
T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse.The Journal of allergy and clinical immunology, 109 5
Zhi Chen, J. O’Shea (2008)
Regulation of IL-17 production in human lymphocytes.Cytokine, 41 2
D. Pardoll (2003)
Does the immune system see tumors as foreign or self?Annual review of immunology, 21
C. Carpenito, M. Milone, R. Hassan, Jacqueline Simonet, M. Lakhal, M. Suhoski, Angel Varela-Rohena, K. Haines, D. Heitjan, S. Albelda, R. Carroll, J. Riley, I. Pastan, C. June (2009)
Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domainsProceedings of the National Academy of Sciences, 106
Smita Jaiswal, Todd Pearson, H. Friberg, L. Shultz, D. Greiner, A. Rothman, A. Mathew (2009)
Dengue Virus Infection and Virus-Specific HLA-A2 Restricted Immune Responses in Humanized NOD-scid IL2rγnull MicePLoS ONE, 4
S. Wrzesinski, Y. Wan, R. Flavell (2007)
Transforming Growth Factor-β and the Immune Response: Implications for Anticancer TherapyClinical Cancer Research, 13
J. Letterio, A. Roberts (1998)
REGULATION OF IMMUNE RESPONSES BY TGF-β*Annual Review of Immunology, 16
O. Finn (2003)
Cancer vaccines: between the idea and the realityNature Reviews Immunology, 3
M. Simpson-Abelson, R. Bankert (2008)
Targeting the TCR signaling checkpoint: a therapeutic strategy to reactivate memory T cells in the tumor microenvironmentExpert Opinion on Therapeutic Targets, 12
B Hinz (2007)
10.2353/ajpath.2007.070112Am J Pathol, 170
H. McGettrick, Emily Smith, A. Filer, S. Kissane, M. Salmon, C. Buckley, G. Rainger, G. Nash (2009)
Fibroblasts from different sites may promote or inhibit recruitment of flowing lymphocytes by endothelial cellsEuropean Journal of Immunology, 39
S. Byrne, M. Knox, G. Halliday (2008)
TGFβ is responsible for skin tumour infiltration by macrophages enabling the tumours to escape immune destructionImmunology and Cell Biology, 86
D. Taub, S. Turcovski-Corrales, M. Key, D. Longo, W. Murphy (1996)
Chemokines and T lymphocyte activation: I. Beta chemokines costimulate human T lymphocyte activation in vitro.Journal of immunology, 156 6
M. Shull, I. Ormsby, A. Kier, S. Pawlowski, R. Diebold, M. Yin, Ruth Allen, C. Sidman, G. Proetzel, D. Calvin, Nikki Annunziata, T. Doetschman (1992)
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory diseaseNature, 359
E. Saunier, R. Akhurst (2006)
TGF beta inhibition for cancer therapy.Current cancer drug targets, 6 7
A. Desmoulière (2010)
The Myofibroblast: one function, multiple origins
Simon Jones, N. Horwood, A. Cope, F. Dazzi (2007)
The Antiproliferative Effect of Mesenchymal Stem Cells Is a Fundamental Property Shared by All Stromal Cells1The Journal of Immunology, 179
Y. Zha, R. Marks, A. Ho, A. Peterson, Sujit Janardhan, I. Brown, K. Praveen, S. Stang, J. Stone, T. Gajewski (2006)
T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-αNature Immunology, 7
S. Chiou, B. Sheu, Wen-Chun Chang, Su‐cheng Huang, Ho Hong-Nerng (2005)
Current concepts of tumor-infiltrating lymphocytes in human malignancies.Journal of reproductive immunology, 67 1-2
K. English, F. Barry, C. Field-Corbett, B. Mahon (2007)
IFN-γ and TNF-α differentially regulate immunomodulation by murine mesenchymal stem cellsImmunology Letters, 110
J. Leonard, M. Sherman, G. Fisher, L. Buchanan, G. Larsen, M. Atkins, J. Sosman, J. Dutcher, N. Vogelzang, J. Ryan (1997)
Effects of Single-Dose Interleukin-12 Exposure on Interleukin-12–Associated Toxicity and Interferon-γ ProductionBlood, 90
R. Thompson, Haidong Dong, C. Lohse, B. Leibovich, M. Blute, J. Cheville, E. Kwon (2007)
PD-1 Is Expressed by Tumor-Infiltrating Immune Cells and Is Associated with Poor Outcome for Patients with Renal Cell CarcinomaClinical Cancer Research, 13
T. Boon, P. Coulie, B. Eynde, P. Bruggen (2006)
Human T cell responses against melanoma.Annual review of immunology, 24
Mythili Koneru, David Schaer, N. Monu, A. Ayala, A. Frey (2005)
Defective Proximal TCR Signaling Inhibits CD8+ Tumor-Infiltrating Lymphocyte Lytic FunctionThe Journal of Immunology, 174
D. Valmori, Naira Souleimanian, V. Tosello, N. Bhardwaj, S. Adams, D. O’Neill, A. Pavlick, J. Escalon, Crystal Cruz, A. Angiulli, Francesca Angiulli, G. Mears, S. Vogel, L. Pan, A. Jungbluth, Eric Hoffmann, R. Venhaus, G. Ritter, L. Old, M. Ayyoub (2007)
Vaccination with NY-ESO-1 protein and CpG in Montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-primingProceedings of the National Academy of Sciences, 104
H. Asao, C. Okuyama, S. Kumaki, N. Ishii, S. Tsuchiya, D. Foster, K. Sugamura (2001)
Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex1The Journal of Immunology, 167
C. Bocelli-Tyndall, A. Barbero, C. Candrian, R. Ceredig, A. Tyndall, I. Martin (2006)
Human articular chondrocytes suppress in vitro proliferation of anti‐CD3 activated peripheral blood mononuclear cellsJournal of Cellular Physiology, 209
C. Georganas, Hongtao Liu, H. Perlman, A. Hoffmann, B. Thimmapaya, R. Pope (2000)
Regulation of IL-6 and IL-8 Expression in Rheumatoid Arthritis Synovial Fibroblasts: the Dominant Role for NF-κB But Not C/EBPβ or c-Jun1The Journal of Immunology, 165
L. Broderick, R. Bankert (2006)
Memory T Cells in Human Tumor and Chronic Inflammatory Microenvironments: Sleeping Beauties Re-awakened by a Cytokine KissImmunological Investigations, 35
J. Gallin, I. Goldstein, R. Snyderman (1992)
Inflammation: Basic Principles and Clinical Correlates
SL Gaffen (2009)
10.1038/nri2586Nat Rev Immunol, 9
SK Leivonen (2007)
10.1002/ijc.23113Int J Cancer, 121
M. Bombara, D. Webb, P. Conrad, Christopher Marior, T. Sarr, G. Ranges, T. Aune, Jeffrey Grave, M. Blue (1993)
Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokinesJournal of Leukocyte Biology, 54
Emanuela Zappia, Simona Casazza, E. Pedemonte, F. Benvenuto, I. Bonanni, E. Gerdoni, D. Giunti, A. Ceravolo, Francesco Cazzanti, F. Frassoni, G. Mancardi, A. Uccelli (2005)
Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy.Blood, 106 5
M. Boisvert, S. Gendron, Nizar Chetoui, F. Aoudjit (2007)
Alpha2 beta1 integrin signaling augments T cell receptor-dependent production of interferon-gamma in human T cells.Molecular immunology, 44 15
R. Uzzo, P. Rayman, V. Kolenko, P. Clark, M. Cathcart, T. Bloom, A. Novick, R. Bukowski, T. Hamilton, J. Finke (1999)
Renal cell carcinoma-derived gangliosides suppress nuclear factor-kappaB activation in T cells.The Journal of clinical investigation, 104 6
MO Li, S Sanjabi, YY Wan, AL Robertson, RA Flavell (2006)
Transforming growth factor-b of immune responsesAnnu Rev Immunol, 24
M. Miyara, Y. Yoshioka, A. Kitoh, T. Shima, K. Wing, A. Niwa, C. Parizot, Cécile Taflin, T. Heike, D. Valeyre, A. Mathian, T. Nakahata, Tomoyuki Yamaguchi, T. Nomura, M. Ono, Z. Amoura, G. Gorochov, S. Sakaguchi (2009)
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.Immunity, 30 6
Michael Nazareth, L. Broderick, M. Simpson-Abelson, R. Kelleher, S. Yokota, R. Bankert (2007)
Characterization of Human Lung Tumor-Associated Fibroblasts and Their Ability to Modulate the Activation of Tumor-Associated T Cells1The Journal of Immunology, 178
D. Berd, M. Mastrangelo, E. Lattime, Takami Sato, H. Maguire (1996)
Melanoma and vitiligo: immunology’s Grecian urnCancer Immunology, Immunotherapy, 42
D. Pilling, A. Akbar, J. Girdlestone, C. Orteu, N. Borthwick, N. Amft, D. Scheel-Toellner, C. Buckley, M. Salmon (1999)
Interferon-beta mediates stromal cell rescue of T cells from apoptosis.European journal of immunology, 29 3
M. Simpson-Abelson, V. Purohit, Wing Pang, Vandana Iyer, K. Odunsi, T. Demmy, S. Yokota, Jenni Loyall, R. Kelleher, S. Balu-Iyer, R. Bankert (2009)
IL-12 delivered intratumorally by multilamellar liposomes reactivates memory T cells in human tumor microenvironments.Clinical immunology, 132 1
S. Hess, N. Egilmez, Nicola Bailey, T. Anderson, E. Mathiowitz, S. Bernstein, R. Bankert (2003)
Human CD4+ T Cells Present Within the Microenvironment of Human Lung Tumors Are Mobilized by the Local and Sustained Release of IL-12 to Kill Tumors In Situ by Indirect Effects of IFN-γ1The Journal of Immunology, 170
S. Read, Fiona Powrie (2001)
CD4(+) regulatory T cells.Current opinion in immunology, 13 6
A. Ito, T. Ishida, H. Yano, A. Inagaki, Susumu Suzuki, F. Sato, H. Takino, F. Mori, M. Ri, S. Kusumoto, H. Komatsu, S. Iida, H. Inagaki, R. Ueda (2009)
Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rγnull mouse modelCancer Immunology, Immunotherapy, 58
G. Freeman, E. Wherry, R. Ahmed, A. Sharpe (2006)
Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockadeThe Journal of Experimental Medicine, 203
J. Mestas, C. Hughes (2004)
Of Mice and Not Men: Differences between Mouse and Human ImmunologyThe Journal of Immunology, 172
J. Leonard, M. Sherman, G. Fisher, L. Buchanan, G. Larsen, M. Atkins, J. Sosman, J. Dutcher, N. Vogelzang, J. Ryan (1997)
Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production.Blood, 90 7
J. Galon, A. Costes, F. Sánchez-Cabo, A. Kirilovsky, B. Mlecnik, C. Lagorce-Pagès, M. Tosolini, M. Camus, A. Berger, P. Wind, F. Zinzindohoué, P. Bruneval, P. Cugnenc, Z. Trajanoski, W. Fridman, F. Pagès (2006)
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical OutcomeScience, 313
R. Schwartz (1993)
T cell anergy.Scientific American, 269 2
M. Miranda-Carús, A. Balsa, M. Benito-Miguel, C. Ayala, E. Martı́n-Mola (2004)
IL-15 and the Initiation of Cell Contact-Dependent Synovial Fibroblast-T Lymphocyte Cross-Talk in Rheumatoid Arthritis: Effect of Methotrexate1The Journal of Immunology, 173
K. Wood, S. Sakaguchi (2003)
Regulatory lymphocytes: Regulatory T cells in transplantation toleranceNature Reviews Immunology, 3
H. Hill, T. Conway, M. Sabel, Y. Jong, E. Mathiowitz, R. Bankert, N. Egilmez (2002)
Cancer immunotherapy with interleukin 12 and granulocyte-macrophage colony-stimulating factor-encapsulated microspheres: coinduction of innate and adaptive antitumor immunity and cure of disseminated disease.Cancer research, 62 24
M. Smyth, D. Godfrey, J. Trapani (2001)
A fresh look at tumor immunosurveillance and immunotherapyNature Immunology, 2
M. Vecchio, E. Bajetta, S. Canova, M. Lotze, A. Wesa, G. Parmiani, A. Anichini (2007)
Interleukin-12: Biological Properties and Clinical ApplicationClinical Cancer Research, 13
Y. Yamamura, Raj Gupta, Y. Morita, Xiao-song He, Rajiv Pai, J. Endres, Andrew Freiberg, Kevin Chung, D. Fox (2001)
Effector Function of Resting T Cells: Activation of Synovial Fibroblasts1The Journal of Immunology, 166
M Boisvert (2007)
10.1016/j.molimm.2007.04.003Mol Immunol, 44
S. Radoja, M. Saio, David Schaer, Mythili Koneru, S. Vukmanović, A. Frey (2001)
CD8+ Tumor-Infiltrating T Cells Are Deficient in Perforin-Mediated Cytolytic Activity Due to Defective Microtubule-Organizing Center Mobilization and Lytic Granule ExocytosisThe Journal of Immunology, 167
T. Silzle, G. Randolph, M. Kreutz, L. Kunz-Schughart (2004)
The fibroblast: Sentinel cell and local immune modulator in tumor tissueInternational Journal of Cancer, 108
L. Shultz, B. Lyons, Lisa Burzenski, B. Gott, Xiaohua Chen, S. Chaleff, M. Kotb, S. Gillies, Marie King, Julie Mangada, D. Greiner, R. Handgretinger (2004)
Human Lymphoid and Myeloid Cell Development in NOD/LtSz-scid IL2Rγnull Mice Engrafted with Mobilized Human Hemopoietic Stem Cells 12The Journal of Immunology, 174
R. Weil, A. Israël (2006)
Deciphering the pathway from the TCR to NF-kappaB.Cell death and differentiation, 13 5
J. Bach (2003)
Regulatory lymphocytes: Regulatory T cells under scrutinyNature Reviews Immunology, 3
H. Mizoguchi, J. O’Shea, D. Longo, C. Loeffler, D. McVicar, A. Ochoa (1992)
Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice.Science, 258 5089
A. Nel, N. Slaughter (2002)
T-cell activation through the antigen receptor. Part 2: role of signaling cascades in T-cell differentiation, anergy, immune senescence, and development of immunotherapy.The Journal of allergy and clinical immunology, 109 6
Ilona Kryczek, Shuang Wei, L. Zou, S. Altuwaijri, Wojciech Szeliga, J. Kolls, A. Chang, W. Zou (2007)
Cutting Edge: Th17 and Regulatory T Cell Dynamics and the Regulation by IL-2 in the Tumor Microenvironment1The Journal of Immunology, 178
T. Curiel, G. Coukos, L. Zou, Xavier Alvarez, P. Cheng, P. Mottram, Melina Evdemon-Hogan, J. Conejo-Garcia, Lin Zhang, M. Burow, Yun Zhu, Shuang Wei, Ilona Kryczek, B. Daniel, Alan Gordon, L. Myers, A. Lackner, M. Disis, K. Knutson, Lieping Chen, W. Zou (2004)
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survivalNature Medicine, 10
L. Trautmann, L. Janbazian, N. Chomont, E. Said, S. Gimmig, B. Bessette, M. Boulassel, E. Delwart, H. Sepulveda, R. Balderas, J. Routy, E. Haddad, R. Sékaly (2006)
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunctionNature Medicine, 12
CM Balch, S Soong, HM Shaw, MM Urist, WH McCarthy (1992)
cutaneous melanoma
W. Ng, Phillip Duggan, F. Ponchel, G. Matarese, G. Lombardi, A. Edwards, J. Isaacs, R. Lechler (2001)
Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.Blood, 98 9
D. Dieckmann, Heidi Plottner, S. Berchtold, T. Berger, G. Schuler (2001)
Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human BloodThe Journal of Experimental Medicine, 193
Laurie Davis, N. Oppenheimer-Marks, J. Bednarczyk, Bradley McIntyre, P. Lipsky (1990)
Fibronectin promotes proliferation of naive and memory T cells by signaling through both the VLA-4 and VLA-5 integrin molecules.Journal of immunology, 145 3
S. Agrawal, J. Marquet, M. Delfau-Larue, C. Copie-Bergman, H. Jouault, F. Reyes, A. Bensussan, J. Farcet (1998)
CD3 hyporesponsiveness and in vitro apoptosis are features of T cells from both malignant and nonmalignant secondary lymphoid organs.The Journal of clinical investigation, 102 9
RH Schwartz (2003)
10.1146/annurev.immunol.21.120601.141110Annu Rev Immunol, 21
M. Battaglia, M. Roncarolo (2009)
The fate of human Treg cells.Immunity, 30 6
G. Dunn, A. Bruce, H. Ikeda, L. Old, R. Schreiber (2002)
Cancer immunoediting: from immunosurveillance to tumor escapeNature Immunology, 3
P. Rodriguez, A. Ochoa (2006)
T cell dysfunction in cancer: role of myeloid cells and tumor cells regulating amino acid availability and oxidative stress.Seminars in cancer biology, 16 1
H. Khong, N. Restifo (2002)
Natural selection of tumor variants in the generation of “tumor escape” phenotypesNature Immunology, 3
Transforming Growth Factor (cid:2) Blocks Tec Kinase Phosphorylation, Ca 2 (cid:3) Influx, and NFATc Translocation Causing Inhibition of T Cell Differentiation
M. Akashi, A. Loussararian, D. Adelman, M. Saito, H. Koeffler (1990)
Role of lymphotoxin in expression of interleukin 6 in human fibroblasts. Stimulation and regulation.The Journal of clinical investigation, 85 1
M. Beyer, J. Schultze (2006)
Regulatory T cells in cancer.Blood, 108 3
RH Schwartz (2003)
T cell anergyAnnu Rev Immunol, 21
MG Herrath, LC Harrison (2003)
Antigen-induced regulatory T cells in autoimmunityNat Rev Immunol, 3
S. Hilchey, A. De, L. Rimsza, R. Bankert, S. Bernstein (2007)
Follicular Lymphoma Intratumoral CD4+CD25+GITR+ Regulatory T Cells Potently Suppress CD3/CD28-Costimulated Autologous and Allogeneic CD8+CD25− and CD4+CD25− T Cells1The Journal of Immunology, 178
E. Young, W. Stark (1988)
In vitro immunological function of human corneal fibroblasts.Investigative ophthalmology & visual science, 29 9
(1992)
Histopathology of malignant melanoma and its precursor lesions
A. Rangarajan, R. Weinberg (2003)
Comparative biology of mouse versus human cells: modelling human cancer in miceNature Reviews Cancer, 3
The immune system of cancer patients recognizes tumor-associated antigens expressed on solid tumors and these antigens are able to induce tumor-specific humoral and cellular immune responses. Diverse immunotherapeutic strategies have been used in an attempt to enhance both antibody and T cell responses to tumors. While several tumor vaccination strategies significantly increase the number of tumor-specific lymphocytes in the blood of cancer patients, most vaccinated patients ultimately experience tumor progression. CD4+ and CD8+ T cells with an effector memory phenotype infiltrate human tumor microenvironments, but most are hyporesponsive to stimulation via the T cell receptor (TCR) and CD28 under conditions that activate memory T cells derived from the peripheral blood of the cancer patients or normal donors. Attempts to identify cells and molecules responsible for the TCR signaling arrest of tumor-infiltrating T cells have focused largely upon the immunosuppressive effects of tumor cells, tolerogenic dendritic cells and regulatory T cells. Here we review potential mechanisms by which human T cell function is arrested in the tumor microenvironment with a focus on the immunomodulatory effects of stromal fibroblasts. Determining in vivo which cells and molecules are responsible for the TCR arrest in human tumor-infiltrating T cells will be necessary to formulate and test strategies to prevent or reverse the signaling arrest of the human T cells in situ for a more effective design of tumor vaccines. These questions are now addressable using novel human xenograft models of tumor microenvironments.
Cancer Microenvironment – Springer Journals
Published: Mar 31, 2010
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.