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ISSN 0012-5008, Doklady Chemistry, 2009, Vol. 425, Part 2, pp. 88–90. © Pleiades Publishing, Ltd., 2009. Original Russian Text © I.V. Serkov, V.V. Bezuglov, 2009, published in Doklady Akademii Nauk, 2009, Vol. 425, No. 6, pp. 777–779. CHEMISTRY Synthesis of New Nitroxyalkylamides as Potential Prototypes of Hybrid Nonsteroidal Anti-Inflammatory Drugs Containing NO-Donating Fragment a b I. V. Serkov and V. V. Bezuglov Presented by Academician A.I. Miroshnikov October 21, 2008 Received October 21, 2008 DOI: 10.1134/S0012500809040065 Nonsteroidal anti-inflammatory drugs (NSAIDs) Paracetamol, Indomethacin, Ibuprofen, and other pharmaceuticals are at the different stages of clinical (Aspirin, Indomethacin, Naproxen, Ibuprofen, and oth- ers) are used for many years as antipyretic and anti- trial [7]. inflammatory agents. Moreover, Aspirin is used for the To expand the library of NO-donating NSAIDs, we treatment of ischemia in patients with acute cardiac prepared a number of compounds containing, as the insufficiency and as a prophylactic for cardiovascular NO donor, a nitroxy group bound to the core molecule diseases [1]. However, the long-term use of these phar- via the aminoalcohol linker. We obtained the amides of maceuticals increases the risk of gastrointestinal disor- Indomethacin, Ibuprofen, Aspirin, and salicylic acid ders [2, 3]. The pharmacological properties and side
Doklady Chemistry – Springer Journals
Published: Apr 26, 2009
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