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Synthesis and Characterization of Polyaspartic Acid-Histidine Conjugate as an Analog of Antioxidant Enzymes

Synthesis and Characterization of Polyaspartic Acid-Histidine Conjugate as an Analog of... ISSN 0003-6838, Applied Biochemistry and Microbiology, 2019, Vol. 55, No. 5, pp. 474–481. © Pleiades Publishing, Inc., 2019. Russian Text © The Author(s), 2019, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2019, Vol. 55, No. 5, pp. 451–459. Synthesis and Characterization of Polyaspartic Acid-Histidine Conjugate as an Analog of Antioxidant Enzymes a a a a M. I. Kamalov , G. R. Sadrieva , A. M. Pavlyuk , D. V. Salakhieva , a a, , N. V. Petrova , and T. I. Abdullin * ** Institute of Fundamental Medicine and Biology, Kazan (Volga region) Federal University, Kazan, 420008 Russia *e-mail: tabdulli@gmail.com **e-mail: timur.abdullin@kpfu.ru Received October 31, 2018; revised March 4, 2019; accepted April 22, 2019 Abstract—Polyamino acids are versatile macromolecules with potential to be used as bioactive compounds and drug carriers. Polyaspartic acid (pAsp) and amide conjugate of pAsp with L-histidine (pAsp–His) were synthesized and their catalytic antioxidant properties were studied. pAsp–His did not exhibit the ability to decompose hydrogen peroxide. According to the redox reaction of generation of superoxide radical (SOR) by NADH/phenazine methosulfate, pAsp–His at a concentration of ≥0.1 mg/mL showed superoxide dismutase (SOD)-like activity similar to that of SOD-2 (100 U/mL). In addition, we showed that L-histidine in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Biochemistry and Microbiology Springer Journals

Synthesis and Characterization of Polyaspartic Acid-Histidine Conjugate as an Analog of Antioxidant Enzymes

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References (29)

Publisher
Springer Journals
Copyright
Copyright © 2019 by Pleiades Publishing, Inc.
Subject
Life Sciences; Biochemistry, general; Microbiology; Medical Microbiology
ISSN
0003-6838
eISSN
1608-3024
DOI
10.1134/S0003683819050065
Publisher site
See Article on Publisher Site

Abstract

ISSN 0003-6838, Applied Biochemistry and Microbiology, 2019, Vol. 55, No. 5, pp. 474–481. © Pleiades Publishing, Inc., 2019. Russian Text © The Author(s), 2019, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2019, Vol. 55, No. 5, pp. 451–459. Synthesis and Characterization of Polyaspartic Acid-Histidine Conjugate as an Analog of Antioxidant Enzymes a a a a M. I. Kamalov , G. R. Sadrieva , A. M. Pavlyuk , D. V. Salakhieva , a a, , N. V. Petrova , and T. I. Abdullin * ** Institute of Fundamental Medicine and Biology, Kazan (Volga region) Federal University, Kazan, 420008 Russia *e-mail: tabdulli@gmail.com **e-mail: timur.abdullin@kpfu.ru Received October 31, 2018; revised March 4, 2019; accepted April 22, 2019 Abstract—Polyamino acids are versatile macromolecules with potential to be used as bioactive compounds and drug carriers. Polyaspartic acid (pAsp) and amide conjugate of pAsp with L-histidine (pAsp–His) were synthesized and their catalytic antioxidant properties were studied. pAsp–His did not exhibit the ability to decompose hydrogen peroxide. According to the redox reaction of generation of superoxide radical (SOR) by NADH/phenazine methosulfate, pAsp–His at a concentration of ≥0.1 mg/mL showed superoxide dismutase (SOD)-like activity similar to that of SOD-2 (100 U/mL). In addition, we showed that L-histidine in

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Applied Biochemistry and Microbiology – Springer Journals

Published: Sep 25, 2019

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