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Background: Antibiotics are biocides or products that inhibit the growth of microorganisms in the living cells and there are extensive works directed to develop efficient antimicrobial agents. The sulfonamide ‑ containing polymers have great potential to resist gram‑ positive or gram‑ negative bacterial and fungal attacks. As a therapeutic agent, the sulfonamides have been reported as antitumor and antimicrobial agents against bacteria, being more potent against gram positive rather than gram negative strains. Design of new classes of inhibitors bearing fluorescent tails, as thera‑ peutic and imaging agents, is currently an active area of research. Here, we describe the synthesis of a new family of polyamides based on chlorophenyl‑ 3,5‑ diaminobenzamides, methyl substituted pyrimidinoamido‑ 3,5‑ diamino‑ ben‑ zamides and methyl substituted pyrimidinosulfonamido‑ 3,5‑ diaminobenzamides and evaluation of their thermal, optical and antimicrobial properties. Results: We report the synthesis of a new series of nanosized polyamides containing bioactive pendent structures. The spherical nanosized polymer particles are soluble in many organic solvents and exhibited emissions ranging from blue to orange wavelength depending on the nature of the signaling unit. Pyrimidine‑ and p‑ chloroaromatic contain‑ ing polymers exhibited higher bioactivity than that contain the sulfonamide group. The amidopyrimidine polymers exhibited remarkable antifungal
Chemistry Central Journal – Springer Journals
Published: Aug 19, 2015
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