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R. Munro, F. Hechtel, R. Sawyer (1989)
Sustained Bleeding after a leech Bite in the Apparent Absence of HirudinThrombosis and Haemostasis, 61
C. Bergmann, J. Dodt, S. Köhler, E. Fink, H. Gassen (1986)
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Sustained bleeding after
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Cloning and expression of a cDNA coding for the anticoagulant hirudin from the blood - sucking leech Hirudo medicinalis
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Calin - a platelet
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Cloning and expression of a cDNA coding for the anticoagulant hirudin from the bloodsucking leech, Hirudo medicinalis.Proceedings of the National Academy of Sciences of the United States of America, 83 4
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Calin--a platelet adhesion inhibitor from the saliva of the medicinal leech.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2 1
Prolongation of haemostatic parameters in the host achieved by hatchlingHirudo medicinalis differs quantitatively but not qualitatively from those achieved by adult leeches. The duration and the rate of blood loss from the bite wounds, the gain in body weight of leeches and the duration of feeding each increase with successive feeding episodes. The mean duration of bleeding from bite wounds of hatchling leeches feeding for the first time on human volunteers was 43 min compared to 6 min from control incisions and 600 min in adult leeches. The mean ‘whole body’ concentration of hirudin in 2-week-old hatchlings was 10 antithrombin units (AT-U) compared to 285 AT-U in the head of each adult leech.
Comparative Clinical Pathology – Springer Journals
Published: Nov 5, 2008
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