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Survival of airborne influenza virus: Effects of propagating host, relative humidity, and composition of spray fluids

Survival of airborne influenza virus: Effects of propagating host, relative humidity, and... Influenza A virus, strain WSNH, propagated in bovine, human and chick embryo cell cultures and aerosolized from the cell culture medium, was maximally stable at low relative humidity (RH), minimally stable at mid-range RH, and moderately stable at high RH. Most lots of WSNH virus propagated in embryonated eggs and aerosolized from the allantoic fluid were also least stable at mid-range RH, but two preparations after multiple serial passage in eggs showed equal stability at mid-range and higher RH's. Airborne stability varied from preparation to preparation of virus propagated both in cell culture and embryonated eggs. There was no apparent correlation between airborne stability and protein content of spray fluid above 0.1 mg/ml, but one preparation of lesser protein concentration was extremely unstable at 50 to 80 per cent RH. Polyhydroxy compounds exerted a protective effect on airborne stability. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Survival of airborne influenza virus: Effects of propagating host, relative humidity, and composition of spray fluids

Archives of Virology , Volume 51 (4) – Mar 2, 2005

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References (22)

Publisher
Springer Journals
Copyright
Copyright © 1976 by Springer-Verlag
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
DOI
10.1007/BF01317930
Publisher site
See Article on Publisher Site

Abstract

Influenza A virus, strain WSNH, propagated in bovine, human and chick embryo cell cultures and aerosolized from the cell culture medium, was maximally stable at low relative humidity (RH), minimally stable at mid-range RH, and moderately stable at high RH. Most lots of WSNH virus propagated in embryonated eggs and aerosolized from the allantoic fluid were also least stable at mid-range RH, but two preparations after multiple serial passage in eggs showed equal stability at mid-range and higher RH's. Airborne stability varied from preparation to preparation of virus propagated both in cell culture and embryonated eggs. There was no apparent correlation between airborne stability and protein content of spray fluid above 0.1 mg/ml, but one preparation of lesser protein concentration was extremely unstable at 50 to 80 per cent RH. Polyhydroxy compounds exerted a protective effect on airborne stability.

Journal

Archives of VirologySpringer Journals

Published: Mar 2, 2005

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