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Subcellular aging markers of retinal pigment epithelium in Japanese quail Coturnix japonica

Subcellular aging markers of retinal pigment epithelium in Japanese quail Coturnix japonica Age-related changes of retinal pigment epithelium of the Japanese quail, which at present is a promising experimental model of accelerated aging, were studied by electron microscopy using morphometric analysis. It was established that, along with accumulation of lipofuscin granules and ultrastructural changes of the Bruch’s membrane, changes in the shape of nuclei and mitochondria (increase in the portion of ring-shaped and dumbbell-like mitochondria), decrease in the amount of myeloid bodies, and disorganization of basal infoldings are also aging markers of retinal pigment epithelium. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Moscow University Biological Sciences Bulletin Springer Journals

Subcellular aging markers of retinal pigment epithelium in Japanese quail Coturnix japonica

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References (31)

Publisher
Springer Journals
Copyright
Copyright © 2013 by Allerton Press, Inc.
Subject
Life Sciences; Biochemistry, general; Cell Biology; Life Sciences, general; Plant Sciences; Zoology
ISSN
0096-3925
eISSN
1934-791X
DOI
10.3103/S0096392513040093
Publisher site
See Article on Publisher Site

Abstract

Age-related changes of retinal pigment epithelium of the Japanese quail, which at present is a promising experimental model of accelerated aging, were studied by electron microscopy using morphometric analysis. It was established that, along with accumulation of lipofuscin granules and ultrastructural changes of the Bruch’s membrane, changes in the shape of nuclei and mitochondria (increase in the portion of ring-shaped and dumbbell-like mitochondria), decrease in the amount of myeloid bodies, and disorganization of basal infoldings are also aging markers of retinal pigment epithelium.

Journal

Moscow University Biological Sciences BulletinSpringer Journals

Published: Jan 29, 2014

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