Access the full text.
Sign up today, get DeepDyve free for 14 days.
MA Ostrovskii, AE Dontsov, NL Sakina, M Boulton, J Jarvis-Evans (1992)
Ability of lipofuscin granules of the retinal pigment epithelium of the human eye to photosensitized lipid peroxidation under the action of visible lightSens. Sist., 6
S Julien, U Schraermeyer (2012)
Neurobiol. Aging
J Wassel, S Davis, W Bardesley, M Boulton (1999)
The photoreactivity of the retinal age pigment lipofuscinJ. Biol. Chem., 274
MA Yakovleva, NL Sakina, AS Kanonikhin, TB Fel’dman, EE Nikolaev (2006)
Detection and study of the products of photooxidation of N-retinylidene-N-retinylethanolamine (A2E), the fluorophore of lipofuscin granules from retinal pigment epithelium of human donor eyesDokl. Biochem. Biophys., 409
F Khachik, FF Moura, DY Zhao, CP Aebischer, PS Bernstein (2002)
Transformations of selected carotenoids in plasma, liver, and ocular tissues of humans and in nonprimate animal modelsInvest. Ophthalmol. Vis. Sci., 43
R Ehrlich, A Harris, NS Kheradiya, DM Winston, TA Ciulla, B Wirostko (2008)
Age-Related macular degeneration and the aging eyeClin. Interv. Aging, 3
M Boulton, A Dontsov, M Ostrovsky, J JarvisEvans, D Svistunenko (1993)
Lipofuscin is a photoinducible free radical generatorJ. Photochem. Photobiol., 19
JK Lauber (1982)
Retinal pigment epithelium: ring mitochondria and lesions induced by continuous lightCurr. Eye Res., 2
CJ Kennedy, PE Rakoczy, IJ Constable (1995)
Eye
D Abran, DH Dickson (1992)
Biogenesis of myeloid bodies in regenerating newt (Notophthalmus viridescens) retinal pigment epitheliumCell Tissue Res., 268
IT Kim, JS Kwak (1996)
Degradation of phagosomes and diurnal changes of lysosomes in rattit retinal pigment epitheliumKorean J. Ophthalmol., 10
SV Trofimova, VKh Khavinson (2002)
Usp. Gerontol.
DH Dickson, HL Harvey (1992)
Myeloid body development in the chick retinal pigment epitheliumCurr. Eye Res., 11
PP Zak, AV Zykova, NN Trofimova, EN Eskina, MA Ostrovskii (2012)
An experimental model of accelerated aging of the retina: the Japanese quail Coturnix japonicaSens. Sist., 26
Z Almsherqi, CS McLachlan, SK Tay, Y Deng (2007)
Chronic phenobarbital-induced mitochondrial pleomorphism in the rat liverToxicol. Pathol., 35
PT Johnson, GP Lewis, KC Talada, MN Brown, PJ Kappel, LV Johnson (2003)
Drusen-associated degeneration in the retinaInvest Ophthalmol. Vis. Sci., 44
H Liang, SG Crewther, DP Crewther (1995)
A model for the formation of ring mitochondria in retinal pigment epitheliumYan Ke Xue Bao, 11
LV Johnson, DL Forest, CD Banna, CM Radeke, MA Maloney, J Hu, CN Spencer, AM Walker, MS Tsie, D Bok, MJ Radeke, DH Anderson (2011)
Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degenerationProc. Natl. Acad. Sci. U.S.A., 108
AE Dontsov, RD Glickman, MA Ostrovsky (1999)
Retinal pigment and epithelium pigment granules stimulate the photo-oxidation of unsaturated fatty acidsFree Radic. Biol. Med., 26
L Wang, ME Clark, DK Crossman, K Kojima, JD Messinger, JA Mobley, CA Curcio (2010)
Abundant lipid and protein components of drusenPLoS One, 5
L Feeney-Burns, ES Hilderbrand, S Eldridqe (1984)
Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cellsInvest. Ophthalmol. Vis. Sci., 25
JZ Nowak (2006)
Age-related macular degeneration (AMD): pathogenesis and therapyPharmacol. Rep., 58
KV Fite, L Bengston, F Cousins (1994)
Drusen-like deposits in the outer retina of Japanese quailExp. Eye Res., 59
KV Fite, L Bengston (1989)
Aging and sex-related changes in the outer retina of Japanese quailCurr. Eye Res., 8
Y Gavrieli, Y Sherman, S Ben-Sasson (1992)
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentationJ. Cell Biol., 119
DG Birch, FQ Liang (2007)
Age-related macular degeneration: a target for nanotechnology derived medicinesInt. J. Nanomed., 2
VL Bonilha (2008)
Age and disease-related structural changes in the retinal pigment epitheliumClin. Ophthalmol., 2
SL Fine, JW Berger, MG Maguire, AC Ho (2000)
Age-related macular degenerationN. Engl. J. Med., 342
MA Ostrovskii (2005)
Photobiological paradox of visionUsp. Biol. Khim., 45
EF Lushnikov, FYu Abrosimov (2001)
Gibel’ kletki (apoptoz)
GG Avtandilov (1980)
Vvedenie v kolichestvennuyu patologicheskuyu morfologiyu
Age-related changes of retinal pigment epithelium of the Japanese quail, which at present is a promising experimental model of accelerated aging, were studied by electron microscopy using morphometric analysis. It was established that, along with accumulation of lipofuscin granules and ultrastructural changes of the Bruch’s membrane, changes in the shape of nuclei and mitochondria (increase in the portion of ring-shaped and dumbbell-like mitochondria), decrease in the amount of myeloid bodies, and disorganization of basal infoldings are also aging markers of retinal pigment epithelium.
Moscow University Biological Sciences Bulletin – Springer Journals
Published: Jan 29, 2014
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.