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Subacute antidiabetic and in vivo antioxidant effects of methanolic extract of Ficus glumosa stem bark on alloxan-induced hyperglycaemic rats

Subacute antidiabetic and in vivo antioxidant effects of methanolic extract of Ficus glumosa stem... Ficus glumosa belongs to the family Moraceae and is commonly called African rock fig. This study evaluated the subacute antidiabetic, in vivo antioxidant and oral glucose tolerance test (OGTT) effects of the methanolic extract of Ficus glumosa stem bark on alloxan-induced hyperglycaemic rats. The extract produced a time-dependent decrease in fasting blood sugar (FBS) level but did not produce dose-dependent effect. The extract produced its optimum effect at the dose of 62.5 mg/kg, since increase beyond this did not produce further reduction in FBS level, rather caused a reduced catalase activity. The extract (62.5 mg/kg) produced significant (p < 0.05) oral glucose tolerance effects in normoglycaemic and hyperglycaemic rats. The extract caused significant (p < 0.05) dose-dependent decrease in the level of thiobarbituric acid reactive substance (TBARS) when compared with the distilled water-treated group. The extract (62.5 mg/kg) produced a significant (p < 0.05) increase in catalase activities when compared to the negative control. This effect was comparable to glibenclamide (2 mg/kg). The results obtained in this study suggest that F. glumosa has antidiabetic and antioxidant activities which may be of benefit in management of postprandial hyperglycaemia and prevention of diabetic complications. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Subacute antidiabetic and in vivo antioxidant effects of methanolic extract of Ficus glumosa stem bark on alloxan-induced hyperglycaemic rats

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Publisher
Springer Journals
Copyright
Copyright © 2014 by Springer-Verlag London
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1618-565X
DOI
10.1007/s00580-014-1896-8
Publisher site
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Abstract

Ficus glumosa belongs to the family Moraceae and is commonly called African rock fig. This study evaluated the subacute antidiabetic, in vivo antioxidant and oral glucose tolerance test (OGTT) effects of the methanolic extract of Ficus glumosa stem bark on alloxan-induced hyperglycaemic rats. The extract produced a time-dependent decrease in fasting blood sugar (FBS) level but did not produce dose-dependent effect. The extract produced its optimum effect at the dose of 62.5 mg/kg, since increase beyond this did not produce further reduction in FBS level, rather caused a reduced catalase activity. The extract (62.5 mg/kg) produced significant (p < 0.05) oral glucose tolerance effects in normoglycaemic and hyperglycaemic rats. The extract caused significant (p < 0.05) dose-dependent decrease in the level of thiobarbituric acid reactive substance (TBARS) when compared with the distilled water-treated group. The extract (62.5 mg/kg) produced a significant (p < 0.05) increase in catalase activities when compared to the negative control. This effect was comparable to glibenclamide (2 mg/kg). The results obtained in this study suggest that F. glumosa has antidiabetic and antioxidant activities which may be of benefit in management of postprandial hyperglycaemia and prevention of diabetic complications.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Feb 21, 2014

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