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Study of Microfocusing Potentialities to Improve Bioparticle Separation Processes: Towards an Experimental Approach

Study of Microfocusing Potentialities to Improve Bioparticle Separation Processes: Towards an... Abstract This work concerns the separation of a mixture of bi-dispersed spherical micro-particles by lateral migration at moderate Reynolds numbers. The expected differential focalization on annular rings of particles flowing in a circular micro-channel according to their size could be of interest for separation processes of poly-dispersed bio-particles suspensions. We propose an original and simple experimental method to study fluorescent particle migration at the microscale which is based on an indirect visualization of their position in a micro-channel. The particles are harvested on a plane filtration membrane put perpendicularly at the outlet of the channel. Their distribution on the membrane is then observed by fluorescent microscopy. A numerical simulation (COMSOL Multiphysics®) was developed to study the influence of membrane permeability and channel/membrane relative positions on the flow streamlines and on the subsequent size of the annular ring formed on the membrane by the focused particles. First experiments have been performed with suspensions of 1 and 4.8 μm diameter particles in order to correlate their positions to experimental conditions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Flow Chemistry Springer Journals

Study of Microfocusing Potentialities to Improve Bioparticle Separation Processes: Towards an Experimental Approach

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References (15)

Publisher
Springer Journals
Copyright
2013 Akadémiai Kiadó
ISSN
2062-249X
eISSN
2063-0212
DOI
10.1556/jfc-d-13-00010
Publisher site
See Article on Publisher Site

Abstract

Abstract This work concerns the separation of a mixture of bi-dispersed spherical micro-particles by lateral migration at moderate Reynolds numbers. The expected differential focalization on annular rings of particles flowing in a circular micro-channel according to their size could be of interest for separation processes of poly-dispersed bio-particles suspensions. We propose an original and simple experimental method to study fluorescent particle migration at the microscale which is based on an indirect visualization of their position in a micro-channel. The particles are harvested on a plane filtration membrane put perpendicularly at the outlet of the channel. Their distribution on the membrane is then observed by fluorescent microscopy. A numerical simulation (COMSOL Multiphysics®) was developed to study the influence of membrane permeability and channel/membrane relative positions on the flow streamlines and on the subsequent size of the annular ring formed on the membrane by the focused particles. First experiments have been performed with suspensions of 1 and 4.8 μm diameter particles in order to correlate their positions to experimental conditions.

Journal

Journal of Flow Chemistry – Springer Journals

Published: Jul 1, 2013

Keywords: chemistry/food science, general; green chemistry; organic chemistry; inorganic chemistry; nanochemistry; industrial chemistry/chemical engineering

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