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Manisha Pande, Ashish Mehta, B. Pant, S. Flora (2001)
Combined administration of a chelating agent and an antioxidant in the prevention and treatment of acute lead intoxication in rats.Environmental toxicology and pharmacology, 9 4
G. Winston, R. Giulio (1991)
Prooxidant and antioxidant mechanisms in aquatic organismsAquatic Toxicology, 19
W. Dai, L. Fu, Huahua Du, Chengguan Jin, Zi-rong Xu (2009)
Changes in Growth Performance, Metabolic Enzyme Activities, and Content of Fe, Cu, and Zn in Liver and Kidney of Tilapia (Oreochromis niloticus) Exposed to Dietary PbBiological Trace Element Research, 128
S. Flora, Geetu Saxena, Pratibha Gautam, P. Kaur, K. Gill (2007)
Response of lead-induced oxidative stress and alterations in biogenic amines in different rat brain regions to combined administration of DMSA and MiADMSA.Chemico-biological interactions, 170 3
S. Flora, M. Pande, A. Mehta (2003)
Beneficial effect of combined administration of some naturally occurring antioxidants (vitamins) and thiol chelators in the treatment of chronic lead intoxication.Chemico-biological interactions, 145 3
J. Suttnar, L. Mášová, J. Dyr (2001)
Influence of citrate and EDTA anticoagulants on plasma malondialdehyde concentrations estimated by high-performance liquid chromatography.Journal of chromatography. B, Biomedical sciences and applications, 751 1
Geetu Saxena, S. Flora (2004)
Lead‐induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in ratsJournal of Biochemical and Molecular Toxicology, 18
R. Vinodhini, M. Narayanan (2009)
Biochemical changes of antioxidant enzymes in common carp (Cyprinus carpio L.) after heavy metal exposureTurkish Journal of Veterinary & Animal Sciences, 33
F. Torre, F. Torre, A. Salibián, L. Ferrari (2000)
Biomarkers assessment in juvenile Cyprinus carpio exposed to waterborne cadmium.Environmental pollution, 109 2
E. Padmini, M. Rani (2009)
Evaluation of oxidative stress biomarkers in hepatocytes of grey mullet inhabiting natural and polluted estuaries.The Science of the total environment, 407 15
Z. Placer, Linda Cushman, B. Johnson (1966)
Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems.Analytical biochemistry, 16 2
Nagaraja Haleagraha, T. Jackie, S. Chakravart, A. Kulur (2011)
Protective Effect of Alpha-lipoic Acid Against Lead Acetate-Induced Oxidative Stress in the Bone Marrow of RatsInternational Journal of Pharmacology, 7
A. Rani (2000)
Cadmium‐Induced Bioaccumulation in the Selected Tissues of a Freshwater Teleost, Oreochromis mossambicus (Tilapia)Annals of the New York Academy of Sciences, 919
J. Meldrum, Kam Ko (2003)
Effects of calcium disodium EDTA and meso-2,3-dimercaptosuccinic acid on tissue concentrations of lead for use in treatment of calves with experimentally induced lead toxicosis.American journal of veterinary research, 64 6
K. Kalia, S. Flora (2005)
Strategies for Safe and Effective Therapeutic Measures for Chronic Arsenic and Lead PoisoningJournal of Occupational Health, 47
D. Monteiro, F. Rantin, A. Kalinin (2010)
Inorganic mercury exposure: toxicological effects, oxidative stress biomarkers and bioaccumulation in the tropical freshwater fish matrinxã, Brycon amazonicus (Spix and Agassiz, 1829)Ecotoxicology, 19
Nukhet Aykin-Burns, A. Laegeler, Gary Kellogg, N. Ercal (2003)
Oxidative Effects of Lead in Young and Adult Fisher 344 RatsArchives of Environmental Contamination and Toxicology, 44
L. Patrick (2006)
Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity.Alternative medicine review : a journal of clinical therapeutic, 11 2
Veena Sharma, Arti Sharma, Leena Kansal (2010)
The effect of oral administration of Allium sativum extracts on lead nitrate induced toxicity in male mice.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48 3
H. Baghshani, D. Shahsavani (2013)
Effects of lead acetate exposure on metabolic enzyme activities in selected tissues of common carp (Cyprinus carpio)Comparative Clinical Pathology, 22
I. Todorova, G. Simeonova, D. Kyuchukova, D. Dinev, V. Gadjeva (2005)
Reference values of oxidative stress parameters (MDA, SOD, CAT) in dogs and catsComparative Clinical Pathology, 13
B. Velmurugan, M. Selvanayagam, E. Cengiz, E. Uysal (2008)
Levels of transaminases, alkaline phosphatase, and protein in tissues of Clarias gariepienus fingerlings exposed to sublethal concentrations of cadmium chlorideEnvironmental Toxicology, 23
D. Shahsavani, H. Baghshani, M. Aslani, F. Fatemi (2012)
The impact of allicin on lead-induced oxidative damage in selected organs of the common carp (Cyprinus carpio)Comparative Clinical Pathology, 21
V. Lushchak, T. Bagnyukova, V. Husak, L. Luzhna, O. Lushchak, K. Storey (2005)
Hyperoxia results in transient oxidative stress and an adaptive response by antioxidant enzymes in goldfish tissues.The international journal of biochemistry & cell biology, 37 8
E. Casillas, M. Myers, W. Ames (1983)
Relationship of serum chemistry values to liver and kidney histopathology in English sole (Parophrys vetulus) after acute exposure to carbon tetrachlorideAquatic Toxicology, 3
Chunhong Wang, Yan Zhang, Jiancheng Liang, Guang Shan, Yan Wang, Qun Shi (2006)
Impacts of ascorbic acid and thiamine supplementation at different concentrations on lead toxicity in testis.Clinica chimica acta; international journal of clinical chemistry, 370 1-2
Qufei Ling, F. Hong (2010)
Antioxidative role of cerium against the toxicity of lead in the liver of silver crucian carpFish Physiology and Biochemistry, 36
E. Massó-González, M. Antonio-García (2009)
Natural antioxidants protect against lead-induced damage during pregnancy and lactation in rat's pups.Ecotoxicology and environmental safety, 72 8
J. Rogers, C. Wood (2004)
Characterization of branchial lead-calcium interaction in the freshwater rainbow trout Oncorhynchus mykissJournal of Experimental Biology, 207
Chunhong Wang, Jiancheng Liang, Chunlian Zhang, Y. Bi, Xianglin Shi, Qun Shi (2007)
Effect of ascorbic Acid and thiamine supplementation at different concentrations on lead toxicity in liver.The Annals of occupational hygiene, 51 6
The present study has been undertaken to evaluate the possible protective effects of ascorbic acid and thiamine on modulating lead-induced lipid and protein oxidation as well as metabolic enzyme alterations in some tissues of common carp. Fish were divided into 4 groups, as follows: group A served as control; group B received lead acetate (5 mg L−1, 15 days); and group C and D received ascorbic acid (500 mg kg−1 feed) and thiamine (50 mg kg−1 feed) respectively, in addition to lead acetate. Lead acetate exposure caused significant increase in MDA content in liver, kidney, and brain as well as carbonyl content in the liver compared with control group (P < 0.05). Significant increase was also observed in enzymatic activities of aspartate amino transferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in the liver and alanine aminotransferase (ALT) and LDH in the kidney following lead exposure. Thiamine, but not vitamin C, administration caused significant decrease of MDA concentration in the brain as compared to the group receiving only lead. Moreover, administration of these two vitamins in groups C and D attenuated the hepatic protein carbonyl contents to the levels that were not significantly different from control group. Ascorbic acid supplementation effectively decreased the Pb-induced augmented levels of hepatic AST, LDH, and ALP and renal LDH and ALT activities to the levels that were not significantly different relative to control group. Indeed, thiamine decreased the elevated levels of liver ALP and LDH and kidney ALT and LDH to the levels that had no significant difference with control group. The results of the present investigation show that these two vitamins might be considered as effective and safe preventive treatments in preserving tissues against toxic effects of lead in common carp.
Comparative Clinical Pathology – Springer Journals
Published: Jan 20, 2015
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