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Studies into the Effect of “Mild” Uncoupling with 2,4-Dinitrophenol on the Growth of Chinese Hamster Cell Culture and Its Subsequent Dying out in the Stationary Phase

Studies into the Effect of “Mild” Uncoupling with 2,4-Dinitrophenol on the Growth of Chinese... ISSN 0096-3925, Moscow University Biological Sciences Bulletin, 2019, Vol. 74, No. 3, pp. 163–169. © Allerton Press, Inc., 2019. Russian Text © The Author(s), 2019, published in Vestnik Moskovskogo Universiteta, Seriya 16: Biologiya, 2019, Vol. 74, No. 3, pp. 207–214. RESEARCH ARTICLE Studies into the Effect of “Mild” Uncoupling with 2,4-Dinitrophenol on the Growth of Chinese Hamster Cell Culture and Its Subsequent Dying out in the Stationary Phase a, a a a G. V. Morgunova *, A. F. Karmushakov , A. A. Klebanov and A. N. Khokhlov Evolutionary Cytogerontology Sector, School of Biology, Moscow State University, Moscow, 119234 Russia *e-mail: morgunova@mail.bio.msu.ru Received April 30, 2019; revised June 10, 2019; accepted July 8, 2019 Abstract—Partial uncoupling of the processes of oxidative phosphorylation and energy storage in the form of ATP (“mild” uncoupling) helps reduce the production of reactive oxygen species and can also mimic the effect of calorie restriction. A number of studies have shown that uncouplers, such as 2,4-dinitrophenol (DNP), affect the lifespan of Drosophila, yeast, mice, and rats as well as the manifestation of “age-related” changes in cultures of mammalian and human cells undergoing replicative senescence. This paper is devoted to studying the effect of DNP on the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Moscow University Biological Sciences Bulletin Springer Journals

Studies into the Effect of “Mild” Uncoupling with 2,4-Dinitrophenol on the Growth of Chinese Hamster Cell Culture and Its Subsequent Dying out in the Stationary Phase

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References (35)

Publisher
Springer Journals
Copyright
Copyright © 2019 by Allerton Press, Inc.
Subject
Life Sciences; Biochemistry, general; Cell Biology; Life Sciences, general; Plant Sciences; Zoology
ISSN
0096-3925
eISSN
1934-791X
DOI
10.3103/S0096392519030088
Publisher site
See Article on Publisher Site

Abstract

ISSN 0096-3925, Moscow University Biological Sciences Bulletin, 2019, Vol. 74, No. 3, pp. 163–169. © Allerton Press, Inc., 2019. Russian Text © The Author(s), 2019, published in Vestnik Moskovskogo Universiteta, Seriya 16: Biologiya, 2019, Vol. 74, No. 3, pp. 207–214. RESEARCH ARTICLE Studies into the Effect of “Mild” Uncoupling with 2,4-Dinitrophenol on the Growth of Chinese Hamster Cell Culture and Its Subsequent Dying out in the Stationary Phase a, a a a G. V. Morgunova *, A. F. Karmushakov , A. A. Klebanov and A. N. Khokhlov Evolutionary Cytogerontology Sector, School of Biology, Moscow State University, Moscow, 119234 Russia *e-mail: morgunova@mail.bio.msu.ru Received April 30, 2019; revised June 10, 2019; accepted July 8, 2019 Abstract—Partial uncoupling of the processes of oxidative phosphorylation and energy storage in the form of ATP (“mild” uncoupling) helps reduce the production of reactive oxygen species and can also mimic the effect of calorie restriction. A number of studies have shown that uncouplers, such as 2,4-dinitrophenol (DNP), affect the lifespan of Drosophila, yeast, mice, and rats as well as the manifestation of “age-related” changes in cultures of mammalian and human cells undergoing replicative senescence. This paper is devoted to studying the effect of DNP on the

Journal

Moscow University Biological Sciences Bulletin – Springer Journals

Published: Nov 12, 2019

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