Access the full text.
Sign up today, get DeepDyve free for 14 days.
L. Wilkins (1994)
National Cholesterol Education Program. Second Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II).Circulation, 89 3
A. Tonkin, P. Alyward, D. Colquhoun, P. Glasziou, P. Harris, D. Hunt, A. Keech, S. MacMahon, P. Magnus, D. Newel, P. Nestel, N. Sharpe, J. Shaw, R. Simes, P. Thompson, A. Thompson, M. West, H. White, S. Simes, W. Hague, S. Caleo, Jane Hall, Andrew Martin, S. Mulray, P. Barter, L. Beilin, R. Collins, J. McNeil, P. Meier, H. Willimott, D. Smithers, P. Wallace, J. Baker, M. Hobbs, D. Sullivan, N. Anderson, G. Hankey, J. Watson, M. Arulchelvam, S. Chup, J. Daly, J. Hanna, A. Leach, M. Lee, J. Loughhead, H. Lundie-Jenkin, J. Morrison, S. Netting, A. Nguyen, H. Pater, R. Philip, G. Pinna, D. Rattos, S. Ryerson, V. Sazhin, R. Walsh, A. Claque, M. Mackie, J. Yallop, K. Boss, M. Shepard, J. Leach, M. Gandy, J. Joughin, J. Seabrook, R. Abraham, J. Allen, F. Bates, I. Beinart, E. Breed, D. Brown, N. Bunyan, D. Calvert, T. Campbell, D. Condon‐Paoloni, B. Conway, L. Coupland, J. Crowe, N. Cunio, B. Cuthbert, N. Cuthbert, S. D'arcy, P. Davidson, B. Dwyer, J. England, C. Friend, G. Fulcher, S. Grant, K. Hellestrand, M. Kava, L. Kritharides, D. McGill, H. McKee, A. Mclean, M. Neaverson, G. Nelson, M. O'Neill, C. Onuma, F. O'Reilly (1998)
Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels.The New England journal of medicine, 339 19
Daniel Alonso, P. Starek, Minick Cr (1977)
Studies on the pathogenesis of atheroarteriosclerosis induced in rabbit cardiac allografts by the synergy of graft rejection and hypercholesterolemia.The American journal of pathology, 87 2
Hannah Valantine (1995)
Role of lipids in allograft vascular disease: a multicenter study of intimal thickening detected by intravascular ultrasound.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 14 6 Pt 2
A. Olsson, J. Mcmurray, G. Thorgeirsson, C. Spaulding, J. Slattery, K. Pyörälä, O. Faergeman, R. Wright, Kåre Berg, L. Wilhelmsen, T. Pedersen, T. Miettinen, H. White, J. Kjekshus, M. Gnant (1994)
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). 1994.Atherosclerosis. Supplements, 5 3
J. Downs, M. Clearfield, S. Weis, E. Whitney, D. Shapiro, P. Beere, A. Langendorfer, E. Stein, W. Kruyer, A. Gotto (1998)
Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study.JAMA, 279 20
J. Gurecki, V. Warty, A. Sanghvi (1985)
The transport of cyclosporine in association with plasma lipoproteins in heart and liver transplant patients.Transplantation proceedings, 17 4
M. Costanzo, D. Naftel, M. Pritzker, J. Heilman, J. Boehmer, S. Brozena, G. Dec, H. Ventura, J. Kirklin, R. Bourge, L. Miller (1998)
Heart transplant coronary artery disease detected by coronary angiography: a multiinstitutional study of preoperative donor and recipient risk factors. Cardiac Transplant Research Database.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 17 8
M.R. Costanzo, D.C. Naftel, M.R. Pritzker (1998)
Heart transplant coronary artery disease detected by coronary angiography: a multi-institutional study of preoperative donor and recipient risk factorsJ Heart Lung Transplant, 17
P. Duell, W. Connor, D. Illingworth (1998)
Rhabdomyolysis after taking atorvastatin with gemfibrozil.The American journal of cardiology, 81 3
T. Drüeke, Z. Abdulmassih, B. Lacour, C. Bader, A. Chevalier, H. Kreis (1991)
Atherosclerosis and lipid disorders after renal transplantation.Kidney international. Supplement, 31
D. Becker, B. Chamberlain, R. Swank, M. Hegewald, R. Girardet, K. Baughman, P. Kwiterovich, T. Pearson, W. Ettinger, D. Renlund (1988)
Relationship between corticosteroid exposure and plasma lipid levels in heart transplant recipients.The American journal of medicine, 85 5
Jai-Wun Park, R. Siekmeier, P. Lattke, M. Merz, Comnelia Mix, Stefan Schuiler, W. Jaross (2001)
Pharmacokinetics and Pharmacodynamics of Fluvastatin in Heart Transplant Recipients Taking Cyclosporine AJournal of Cardiovascular Pharmacology and Therapeutics, 6
D. Schwenke (1998)
Antioxidants and atherogenesisJournal of Nutritional Biochemistry, 9
C. Manzarbeitia, D. Reich, K. Rothstein, L. Braitman, Scott Levin, S. Munoz (2001)
Tacrolimus conversion improves hyperlipidemic states in stable liver transplant recipientsLiver Transplantation, 7
D. Renlund, M. Bristow, B. Crandall, N. Burton, D. Doty, S. Karwande, W. Gay, K. Jones, M. Hegewald, M. Hagan (1989)
Hypercholesterolemia after heart transplantation: amelioration by corticosteroid-free maintenance immunosuppression.The Journal of heart transplantation, 8 3
Donald Cramer, Shi Qian, Harnaha, F. Chapman, Larry Estes, T. Starzl, L. Makowka (1989)
Cardiac transplantation in the rat. I. The effect of histocompatibility differences on graft arteriosclerosis.Transplantation, 47 3
J. Farmer, C. Ballantyne, O. Frazier, B. Radovančević, C. Payton-Ross, W. Patsch, J. Morrisett, A. Gotto, J. Young (1991)
Lipoprotein(a) and apolipoprotein changes after cardiac transplantation.Journal of the American College of Cardiology, 18 4
S.J. Lewis, F.M. Sacks, J.S. Mitchell (1998)
Effect of pravastatin on cardiovascular events in women after myocardial infarctionJ Am Coll Cardiol, 32
C. Rokitansky (1852)
A manual of pathological anatomy translated by Day
P. Häyry, H. Isoniemi, S. Yilmaz, A. Mennander, K. Lemström, A. Räisänen‐Sokolowski, P. Koskinen, J. Ustinov, I. Lautenschlager, E. Taskinen, L. Krogerus, P. Aho, T. Paavonen (1993)
Chronic Allograft RejectionImmunological Reviews, 134
D. Sgoutas, W. Macmahon, Ann Love, I. Jerkunica (1986)
Interaction of cyclosporin A with human lipoproteins *Journal of Pharmacy and Pharmacology, 38
D. Patel, F. Pagani, T. Koelling, D. Dyke, R. Baliga, R. Cody, K. Lake, K. Aaronson (2002)
Safety and efficacy of atorvastatin in heart transplant recipients.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 21 2
G. Kuster, H. Drexel, J. Bleisch, K. Rentsch, P. Pei, U. Binswanger, F. Amann (1994)
Relation of cyclosporine blood levels to adverse effects on lipoproteins.Transplantation, 57 10
C. Johnson, N. Ahsan, T. Gonwa, P. Halloran, M. Stegall, M. Hardy, R. Metzger, C. Shield, L. Rocher, J. Scandling, J. Sorensen, L. Mulloy, J. Light, C. Corwin, G. Danovitch, M. Wachs, P. Vanveldhuisen, Kim Salm, D. Tolzman, W. Fitzsimmons (2000)
Randomized trial of tacrolimus (Prograf) in combination with azathioprine or mycophenolate mofetil versus cyclosporine (Neoral) with mycophenolate mofetil after cadaveric kidney transplantation.Transplantation, 69 5
F. Akhlaghi, C. Jackson, J. Parameshwar, L. Sharples, A. Trull (2002)
Risk factors for the development and progression of dyslipidemia after heart transplantationTransplantation, 73
A. Keogh, H. Valantine, S. Hunt (1991)
Predictors of proximal epicardial artery disease after heart transplantation [abstract]J Heart Lung Transplant, 10
A. Laden (1972)
Experimental atherosclerosis in rat and rabbit cardiac allografts.Archives of pathology, 93 3
Robert Abraham (1998)
Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling.Current opinion in immunology, 10 3
E. Meilahn, R. Ferrell (1993)
'Naturally occurring' low blood cholesterol and excess mortality.Coronary artery disease, 4 10
D. Steinberg (1991)
Antioxidants and atherosclerosis. A current assessment.Circulation, 84 3
C. Minick, George Murphy (2007)
Experimental Induction of Atheroarteriosclerosis by the Synergy of Allergic Injury to Arteries and Lipid-Rich Diet Effect of Repeatedly Injected Foreign Protein in Rabbits Fed a Lipid-Rich, Cholesterol-Poor Diet
H.N. Ginsberg, I.J. Goldberg (1998)
Disorders of lipoprotein metabolism: Harrison’s principles of internal medicine
C. Guijarro, Z. Massy, B. Kasiske (1995)
Clinical correlation between renal allograft failure and hyperlipidemia.Kidney international. Supplement, 52
S.M. Grundy (1994)
Second report of the expert panel on detection, evaluation and treatment of high blood cholesterol in adultsCirculation, 89
Miller Lw (1992)
Transplant coronary artery disease.Journal of Heart and Lung Transplantation, 11
A. Dasgupta, D. Powell, S. Saldana, L. Dória (1990)
Elevated lipid peroxidation products and depleted transferrin levels in the plasma of kidney transplant recipients.Life sciences, 46 1
H. Hohage, M. Arlt, D. Brückner, K. Dietl, W. Zidek, C. Spieker (1997)
Effects of cyclosporin A and FK 506 on lipid metabolism and fibrinogen in kidney transplant recipients.Clinical transplantation, 11 3
F. Sacks, M. Pfeffer, L. Moye, J. Rouleau, J. Rutherford, T. Cole, L. Brown, J. Warnica, J. Arnold, C. Wun, B. Davis, E. Braunwald (1996)
The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators.The New England journal of medicine, 335 14
S. Friemann, E. Feuring, W. Padberg, W. Ernst (1998)
Improvement of nephrotoxicity, hypertension, and lipid metabolism after conversion of kidney transplant recipients from cyclosporine to tacrolimus.Transplantation proceedings, 30 4
R. Jensen, S. Lal, A. Diaz-Arias, M. James-Kracke, J. Stone, G. Ross (1995)
Does cholestyramine interfere with cyclosporine absorption? A prospective study in renal transplant patients.ASAIO journal, 41 3
J. Shepherd, S. Cobbe, I. Ford, C. Isles, A. Lorimer, P. Macfarlane, J. Mckillop, C. Packard (1995)
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemiaThe New England Journal of Medicine, 333
M. Mehra, H. Ventura, R. Chambers, T. Collins, S. Ramee, M. Kates, F. Smart, D. Stapleton (1995)
Predictive model to assess risk for cardiac allograft vasculopathy: an intravascular ultrasound study.Journal of the American College of Cardiology, 26 6
J. Mr (1992)
Transplant coronary disease: nonimmunologic risk factors.Journal of Heart and Lung Transplantation, 11
Mario Romano, A. Mezzetti, C. Marulli, G. Ciabattoni, F. Febo, S. DiIenno, S. Roccaforte, Sergio Vigneri, G. Nubile, Massimo Milani, Giovanni Davì (2000)
Fluvastatin reduces soluble P-selectin and ICAM-1 levels in hypercholesterolemic patients: role of nitric oxide.Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 48 3
V. Canzanello, L. Schwartz, S. Taler, S. Textor, R. Wiesner, M. Porayko, R. Krom (1997)
Evolution of cardiovascular risk after liver transplantation: a comparison of cyclosporine A and tacrolimus (FK506).Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 3 1
Shao-Zhou Gao, J. Schroeder, E. Alderman, S. Hunt, H. Valantine, V. Wiederhold, Stinson Eb (1989)
Prevalence of accelerated coronary artery disease in heart transplant survivors. Comparison of cyclosporine and azathioprine regimens.Circulation, 80 5 Pt 2
P. Groen (1988)
Cyclosporine, low-density lipoprotein, and cholesterol.Mayo Clinic Proceedings, 63
Donald Cramer, F. Chapman, GUO-DO Wu, J. Harnaha, Shi Qian, Leonard Makowka (1990)
Cardiac transplantation in the rat. II. Alteration of the severity of donor graft arteriosclerosis by modulation of the host immune response.Transplantation, 50 4
(1973)
Disorders of lipid metabolism.British Medical Journal, 3
A. Tal, M. Rajeshawari, W. Isley (1997)
Rhabdomyolysis associated with simvastatin-gemfibrozil therapy.Southern medical journal, 90 5
G. Magnani, V. Carinci, C. Magelli, L. Potena, L. Reggiani, A. Branzi (2000)
Role of statins in the management of dyslipidemia after cardiac transplant: randomized controlled trial comparing the efficacy and the safety of atorvastatin with pravastatin.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 19 7
D.G. Renlund, M.R. Bristow, B.G. Crandall (1989)
Hypercholesterolemia after heart transplantation; amelioration by corticosteroid-free maintenance immunosuppressionJ Heart Lung Transplant, 8
S. Lewis, F. Sacks, J. Mitchell, C. East, S. Glasser, Sheren Kell, R. Letterer, M. Limacher, L. Moye, J. Rouleau, M. Pfeffer, E. Braunwald (1998)
Effect of pravastatin on cardiovascular events in women after myocardial infarction: the cholesterol and recurrent events (CARE) trial.Journal of the American College of Cardiology, 32 1
J. Trotter, M. Wachs, T. Trouillot, T. Bak, M. Kugelmas, I. Kam, G. Everson (2001)
Dyslipidemia during sirolimus therapy in liver transplant recipients occurs with concomitant cyclosporine but not tacrolimusLiver Transplantation, 7
R. Bermingham, T. Whitsitt, M. Smart, D. Nowak, R. Scalley (2000)
Rhabdomyolysis in a patient receiving the combination of cerivastatin and gemfibrozil.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 57 5
Paul Russell, C. Chase, Henry Winn, Robert Colvin (1994)
Coronary atherosclerosis in transplanted mouse hearts. III. Effects of recipient treatment with a monoclonal antibody to interferon-gamma.Transplantation, 57 9
J. Kobashigawa, J.D. Moriguchi, T.K. Ro (1998)
Atorvastatin for refractory hypercholesterolemia in heart transplant recipients [abstract]J Am Coll Cardiol, 31
J. Kobashigawa, B. Kasiske (1997)
Hyperlipidemia in solid organ transplantation.Transplantation, 63 3
A. Keogh, R. Day, L. Critchley, G. Duggin, D. Baron (1988)
The effect of food and cholestyramine on the absorption of cyclosporine in cardiac transplant recipients.Transplantation proceedings, 20 1
J. Kobashigawa, J. Moriguchi, T. Ro, K. Einhom, J. Cassem, M. Hamilton, A. Hage, N. Kawata, H. Laks (1998)
Atorvastatin for refractory hypercholesterolemia in heart transplant patientsJournal of the American College of Cardiology, 31
T. McCune, L. Thacker, T. Peters, L. Mulloy, M. Rohr, P. Adams, J. Yium, J. Light, T. Pruett, A. Gaber, S. Selman, J. Jonsson, J. Hayes, F. Wright, Thomas Armata, J. Blanton, J. Burdick (1998)
Effects of tacrolimus on hyperlipidemia after successful renal transplantation: a Southeastern Organ Procurement Foundation multicenter clinical study.Transplantation, 65 1
D. Taylor, M. Barr, B. Radovančević, D. Renlund, R. Mentzer, F. Smart, D. Tolman, O. Frazier, James Young, P. Vanveldhuisen (1999)
A randomized, multicenter comparison of tacrolimus and cyclosporine immunosuppressive regimens in cardiac transplantation: decreased hyperlipidemia and hypertension with tacrolimus.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 18 4
L.W. Miller (1992)
Transplant coronary artery disease [editorial]J Heart Lung Transplant, 11
J. Kobashigawa, S. Katznelson, H. Laks, J. Johnson, L. Yeatman, X. Wang, D. Chia, P. Terasaki, A. Sabad, G. Cogert, Kevin Trosian, M. Hamilton, J. Moriguchi, N. Kawata, A. Hage, D. Drinkwater, L. Stevenson (1995)
Effect of pravastatin on outcomes after cardiac transplantation.The New England journal of medicine, 333 10
J.R. Downs, M. Clearfield, S. Weis (1998)
Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPSJAMA, 279
B. Pitt, D. Waters, W.V. Brown (1999)
Aggressive lipid lowering therapy compared with angioplasty in stable coronary artery diseaseN Engl J Med, 341
L. Pierce, D. Wysowski, T. Gross (1990)
Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy.JAMA, 264 1
C.R. Minick, G.E. Murphy (1973)
Experimental induction of atheroarteriosclerosis by the synergy of allergic injury to arteries and lipid-rich dietAm J Pathol, 73
J. Park, M. Vermeltfoort, P. Braun, E. May, M. Merz (1995)
Regression of transplant coronary artery disease during chronic HELP therapy: a case study.Atherosclerosis, 115 1
R. Ross, J. Glomset (1976)
The pathogenesis of atherosclerosisN Engl J Med, 295
R. Virchow
Gesammelte Abhandlungen zur wissenschaftlichen Medicin
D. Adams, M. Russell, W. Hancock, M. Sayegh, L. Wyner, M. Karnovsky (1993)
Chronic Rejection in Experimental Cardiac Transplantation: Studies in the Lewis‐F344 ModelImmunological Reviews, 134
C. Ballantyne, B. Radovančević, J. Farmer, O. Frazier, L. Chandler, C. Payton-Ross, Beth Cocanougher, Peter Jones, James Young, A. Gotto (1992)
Hyperlipidemia after heart transplantation: report of a 6-year experience, with treatment recommendations.Journal of the American College of Cardiology, 19 6
J. Heitman, N. Movva, MN Hall (1991)
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeastScience, 253
F.M. Sacks, M.A. Pfeffer, L.A. Moye (1996)
The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levelsN Engl J Med, 335
R. Ross, J. Glomset (1976)
The pathogenesis of atherosclerosis (first of two parts).The New England journal of medicine, 295 7
M. Quinn, S. Parthasarathy, D. Steinberg (1985)
Endothelial cell-derived chemotactic activity for mouse peritoneal macrophages and the effects of modified forms of low density lipoprotein.Proceedings of the National Academy of Sciences of the United States of America, 82 17
K. Wenke, J. Thiery, B. Meiser (1995)
Long term simvastatin therapy for hypercholesterolemia in heart transplant patientsZ Kardiol, 84
A. Raine, R. Carter, J. Mann, P. Morris (1988)
Adverse effect of cyclosporin on plasma cholesterol in renal transplant recipients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 3 4
R. Ross, J. Glomset (1973)
Atherosclerosis and the Arterial Smooth Muscle CellScience, 180
D. Steinberg, J. Witztum (1990)
Lipoproteins and atherogenesis. Current concepts.JAMA, 264 23
M. Igel, T. Sudhop, K. Bergmann (2001)
Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins)European Journal of Clinical Pharmacology, 57
R. Poston, M. Billingham, E. Hoyt, J. Pollard, R. Shorthouse, R. Morris, R. Robbins (1999)
Rapamycin reverses chronic graft vascular disease in a novel cardiac allograft model.Circulation, 100 1
L. Goldman, J. Bennett (1985)
Cecil Textbook of Medicine
J. Kirk, R. Dupuis (1995)
Approaches to The Treatment of Hyperlipidemia in the Solid Organ Transplant RecipientAnnals of Pharmacotherapy, 29
L. Ost (1987)
Impairment of prednisolone metabolism by cyclosporine treatment in renal graft recipients.Transplantation, 44 4
J. Larosa, Jiang He, S. Vupputuri (1999)
Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials.JAMA, 282 24
Post Investigators (1997)
The effect of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts.The New England journal of medicine, 336 3
K. Wenke, J. Thiery, B. Meiser, N. Arndtz, D. Seidel, B. Reichart (1995)
[Therapy of hypercholesterolemia after heart transplantation with the HMG-CoA reductase inhibitor simvastatin in long-term follow-up].Zeitschrift fur Kardiologie, 84 2
(1994)
Randomized trial of cholesterol lowering in 4444 patients with coronary artery diseaseLancet, 344
A. Chait, R. Ross, J. Albers, E. Bierman (1980)
Platelet-derived growth factor stimulates activity of low density lipoprotein receptors.Proceedings of the National Academy of Sciences of the United States of America, 77 7
C. Shi, M. Russell, C. Bianchi, J. Newell, E. Haber (1994)
Murine model of accelerated transplant arteriosclerosis.Circulation research, 75 2
J. Neylan, Mahmoud Ragab, D. Sgoutas (1994)
CYCLOSPORINE INCREASES THE OXIDIZABILITY OF LOW‐DENSITY LIPOPROTEINS IN RENAL TRANSPLANT RECIPIENTSTransplantation, 58
B. Pitt, D. Waters, W. Brown, A. Boven, L. Schwartz, L. Title, D. Eisenberg, L. Shurzinske, L. McCormick (1999)
Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease. Atorvastatin versus Revascularization Treatment Investigators.The New England journal of medicine, 341 2
D. Steinberg (1991)
Antioxidants and atherogenesis; a current assessmentCirculation, 84
D. Neal, A. Gimson, P. Gibbs, G. Alexander (2001)
Beneficial effects of converting liver transplant recipients from cyclosporine to tacrolimus on blood pressure, serum lipids, and weightLiver Transplantation, 7
K. Wenke, B. Meiser, J. Thiery, D. Nagel, W. Scheidt, G. Steinbeck, D. Seidel, B. Reichart (1997)
Simvastatin reduces graft vessel disease and mortality after heart transplantation: a four-year randomized trial.Circulation, 96 5
Allograft coronary artery disease represents a major limitation to long-term survival after cardiac transplantation. Hyperlipidemias have been linked to the development of native coronary atherosclerosis, and hyperlipidemic states have correlated with the severity of allograft coronary artery disease. Heart transplant recipients typically manifest increases in plasma levels of total cholesterol, low-density lipoprotein-cholesterol (LDL-C), and triglycerides within the first 3–12 months following transplantation. Factors known to promote post-transplant hyperlipidemia include the use of corticosteroids, cyclosporine (interference with clearance and increased oxidizability of LDL), sirolimus (hypertriglyceridemia), and patient-specific causes of hyperlipidemia which contributed to their underlying heart disease. Hydroxymethylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors are the foundation of antilipid therapy following cardiac transplantation. Pravastatin is effective in lowering plasma cholesterol levels and is associated with a decreased incidence and progression of allograft coronary artery disease. All HMG-CoA reductase inhibitors except pravastatin are metabolized by the hepatic cytochrome P450 system which metabolizes cyclosporine, increasing the risk of myostitis when they are used in large dosages with cyclosporine. Simvastatin, atorvastatin and fluvastatin have been studied in heart transplant recipients. Gemfibrozil has proved effective in transplant recipients when there is isolated marked elevation of plasma triglyceride levels. When hyperlipidemia persists despite therapy, some benefit may result with conversion from cyclosporine to tacrolimus.
American Journal of Cardiovascular Drugs – Springer Journals
Published: Aug 20, 2012
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.