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Staying home or leaving for a party: tissue-dependent choices of tissue-resident memory T cells

Staying home or leaving for a party: tissue-dependent choices of tissue-resident memory T cells www.nature.com/cmi RESEARCH HIGHLIGHT Staying home or leaving for a party: tissue-dependent choices of tissue-resident memory T cells 1 2 Klaas P. J. M. van Gisbergen and Joke M. M. den Haan © The Author(s), under exclusive licence to CSI and USTC 2022 Cellular & Molecular Immunology (2022) 19:651–652; https://doi.org/10.1038/s41423-021-00828-z CD8 T cells differentiate into different types of memory T cells Pathogen rechallenge experiments uncovered the functional after priming in the lymphoid organs. Central memory T cells consequences of the distinct phenotypes of liver and skin Trm selectively express lymph node homing markers and recirculate cells. Adoptively transferred liver Trm cells were shown to between the blood and the secondary lymphoid organs. Effector contribute to the formation of circulating T cells in the spleen memory T cells lack lymph node homing capacity, mainly circulate and to the formation of Trm cells in the skin and liver after in the blood, and may enter peripheral tissues. The third subset restimulation. Rechallenge of specifically the Trm population in consists of tissue-resident memory T (Trm) cells that express CD69 liver transplants underlined the wide spectrum in their contribu- and adhesion molecules such as CD11a, CD103, and CD49a that tion to secondary memory responses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cellular & Molecular Immunology Springer Journals

Staying home or leaving for a party: tissue-dependent choices of tissue-resident memory T cells

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References (10)

Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to CSI and USTC 2022
ISSN
1672-7681
eISSN
2042-0226
DOI
10.1038/s41423-021-00828-z
Publisher site
See Article on Publisher Site

Abstract

www.nature.com/cmi RESEARCH HIGHLIGHT Staying home or leaving for a party: tissue-dependent choices of tissue-resident memory T cells 1 2 Klaas P. J. M. van Gisbergen and Joke M. M. den Haan © The Author(s), under exclusive licence to CSI and USTC 2022 Cellular & Molecular Immunology (2022) 19:651–652; https://doi.org/10.1038/s41423-021-00828-z CD8 T cells differentiate into different types of memory T cells Pathogen rechallenge experiments uncovered the functional after priming in the lymphoid organs. Central memory T cells consequences of the distinct phenotypes of liver and skin Trm selectively express lymph node homing markers and recirculate cells. Adoptively transferred liver Trm cells were shown to between the blood and the secondary lymphoid organs. Effector contribute to the formation of circulating T cells in the spleen memory T cells lack lymph node homing capacity, mainly circulate and to the formation of Trm cells in the skin and liver after in the blood, and may enter peripheral tissues. The third subset restimulation. Rechallenge of specifically the Trm population in consists of tissue-resident memory T (Trm) cells that express CD69 liver transplants underlined the wide spectrum in their contribu- and adhesion molecules such as CD11a, CD103, and CD49a that tion to secondary memory responses.

Journal

Cellular & Molecular ImmunologySpringer Journals

Published: Jun 1, 2022

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