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ISSN 0003-6838, Applied Biochemistry and Microbiology, 2019, Vol. 55, No. 4, pp. 371–374. © Pleiades Publishing, Inc., 2019. Russian Text © The Author(s), 2019, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2019, Vol. 55, No. 4, pp. 356–359. a, a a a a M. Yu. Gorshkova *, I. F. Volkova , L. V. Vanchugova , I. L. Valuev , and L. I. Valuev Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, 119991 Russia *e-mail: mgor@ips.ac.ru Received November 16, 2018; revised December 5, 2018; accepted February 20, 2019 Abstract—The potential use of sodium-alginate hydrogels as mucoadhesive drug delivery carriers for intrana- sal application is studied. It is demonstrated that the drug release rate is dependent on the drug solubility in water, the drug concentration in the carrier, and the degree of alginate crosslinking. Keywords: polymer hydrogel, sodium alginate, mucoadhesion, drug delivery system, amino acid DOI: 10.1134/S00036838190 400 45 INTRODUCTION The goal of the work is to study of sodium alginate based hydrogels as mucoadhesive drug delivery sys- The intranasal administration of physiologically tems capable of adhering to mucosa for a period of active substances is one of the oldest, painless meth- time comparable to the time of drug release.
Applied Biochemistry and Microbiology – Springer Journals
Published: Jul 8, 2019
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