Access the full text.
Sign up today, get DeepDyve free for 14 days.
I. Almendros, J. Montserrat, Josep Ramírez, Marta Torres, Joaquín Durán-Cantolla, D. Navajas, Ramon Farré (2011)
Intermittent hypoxia enhances cancer progression in a mouse model of sleep apnoeaEuropean Respiratory Journal, 39
S. Toffoli, C. Michiels (2008)
Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumoursThe FEBS Journal, 275
Xuehong Zhang, E. Giovannucci, K. Wu, Xiang Gao, F. Hu, S. Ogino, E. Schernhammer, C. Fuchs, S. Redline, W. Willett, Jing Ma (2013)
Associations of self-reported sleep duration and snoring with colorectal cancer risk in men and women.Sleep, 36 5
P. Martinive, F. Defresne, C. Bouzin, Julie Saliez, F. Lair, V. Grégoire, C. Michiels, C. Dessy, O. Féron (2006)
Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies.Cancer research, 66 24
Wei-Pin Chang, Mu‐En Liu, Wei-Chiao Chang, A. Yang, Y. Ku, J. Pai, Yea-Wen Lin, S. Tsai (2014)
Sleep apnea and the subsequent risk of breast cancer in women: a nationwide population-based cohort study.Sleep medicine, 15 9
E. Vogtmann, E. Levitan, L. Hale, J. Shikany, N. Shah, Yohannes Endeshaw, C. Lewis, J. Manson, R. Chlebowski (2013)
Association between sleep and breast cancer incidence among postmenopausal women in the Women's Health Initiative.Sleep, 36 10
A. Barceló, F. Barbé (2005)
Estrés oxidativo y síndrome de apneas-hipopneas del sueñoArchivos De Bronconeumologia, 41
C. Savvidis, M. Koutsilieris (2012)
Circadian Rhythm Disruption in Cancer BiologyMolecular Medicine, 18
K. Basen-Engquist, Maria Chang (2011)
Obesity and Cancer Risk: Recent Review and EvidenceCurrent Oncology Reports, 13
C. Lewis, C. Murdoch (2005)
Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies.The American journal of pathology, 167 3
F. Nieto, P. Peppard, T. Young, L. Finn, K. Hla, R. Farré (2012)
Sleep-disordered breathing and cancer mortality: results from the Wisconsin Sleep Cohort Study.American journal of respiratory and critical care medicine, 186 2
A. Palaz, A. Morales-Kastresana, I. Melero (2012)
Molecular Pathways Molecular Pathways : Hypoxia Response in Immune Cells Fighting or Promoting Cancer
P. Verkasalo, K. Lillberg, R. Stevens, C. Hublin, M. Partinen, M. Koskenvuo, J. Kaprio (2005)
Sleep duration and breast cancer: a prospective cohort study.Cancer research, 65 20
I. Almendros, Yang Wang, L. Becker, Frances Lennon, Jiamao Zheng, Brittney Coats, Kelly Schoenfelt, A. Carreras, F. Hakim, Shelley Zhang, R. Farré, D. Gozal (2014)
Intermittent hypoxia-induced changes in tumor-associated macrophages and tumor malignancy in a mouse model of sleep apnea.American journal of respiratory and critical care medicine, 189 5
A. Carreras, Shelley Zhang, I. Almendros, Yang Wang, E. Peris, Zhuanhong Qiao, D. Gozal (2015)
Resveratrol attenuates intermittent hypoxia-induced macrophage migration to visceral white adipose tissue and insulin resistance in male mice.Endocrinology, 156 2
P. Vaupel (2004)
The role of hypoxia-induced factors in tumor progression.The oncologist, 9 Suppl 5
J. Hansen (2001)
Increased Breast Cancer Risk among Women Who Work Predominantly at NightEpidemiology, 12
Jin‐Cherng Chen, Juen-Haur Hwang (2014)
Sleep apnea increased incidence of primary central nervous system cancers: a nationwide cohort study.Sleep medicine, 15 7
Pia Verkasalo, E. Pukkala, Richard Stevens, M. Ojamo, Rudanko Sl (1999)
Inverse association between breast cancer incidence and degree of visual impairment in FinlandBritish Journal of Cancer, 80
Eva Overmeire, Damya Laoui, J. Keirsse, J. Ginderachter (2014)
Hypoxia and tumor-associated macrophagesOncoimmunology, 3
H. Tokunaga, Y. Takebayashi, H. Utsunomiya, J. Akahira, M. Higashimoto, M. Mashiko, K. Ito, H. Niikura, S. Takenoshita, N. Yaegashi (2008)
Clinicopathological significance of circadian rhythm‐related gene expression levels in patients with epithelial ovarian cancerActa Obstetricia et Gynecologica Scandinavica, 87
N. Punjabi (2008)
The epidemiology of adult obstructive sleep apnea.Proceedings of the American Thoracic Society, 5 2
S. Gery, N. Komatsu, L. Baldjyan, A. Yu, Danielle Koo, H. Koeffler (2006)
The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells.Molecular cell, 22 3
A. Christensen, A. Clark, P. Salo, P. Nymann, P. Lange, E. Prescott, N. Rod (2013)
Symptoms of sleep disordered breathing and risk of cancer: a prospective cohort study.Sleep, 36 10
J. McElroy, P. Newcomb, L. Titus-Ernstoff, A. Trentham-Dietz, J. Hampton, K. Egan (2006)
Duration of sleep and breast cancer risk in a large population‐based case–control studyJournal of Sleep Research, 15
A. Wu, Renwei Wang, W. Koh, F. Stanczyk, Hin‐Peng Lee, Mimi Yu (2008)
Sleep duration, melatonin and breast cancer among Chinese women in Singapore.Carcinogenesis, 29 6
I. Almendros, Alex Gileles-Hillel, A. Khalyfa, Yang Wang, Shelley Zhang, A. Carreras, R. Farré, D. Gozal (2015)
Adipose tissue macrophage polarization by intermittent hypoxia in a mouse model of OSA: effect of tumor microenvironment.Cancer letters, 361 2
F. Campos-Rodriguez, M. Martínez-García, Montserrat Martínez, J. Durán-Cantolla, M. Peña, M. Masdeu, Mónica González, F. Campo, Inmaculada Gallego, J. Marin, F. Barbé, J. Montserrat, R. Farré (2013)
Association between obstructive sleep apnea and cancer incidence in a large multicenter Spanish cohort.American journal of respiratory and critical care medicine, 187 1
E. Calle, C. Rodríguez, Kimberly Walker-Thurmond, M. Thun (2003)
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.The New England journal of medicine, 348 17
G. Semenza (2011)
Oxygen sensing, homeostasis, and disease.The New England journal of medicine, 365 6
Xiaomei Xie, L. Pan, Dunqiang Ren, Changjun Du, Yongzhong Guo (2013)
Effects of continuous positive airway pressure therapy on systemic inflammation in obstructive sleep apnea: a meta-analysis.Sleep medicine, 14 11
D. Blask (2009)
Melatonin, sleep disturbance and cancer risk.Sleep medicine reviews, 13 4
E. Haus, M. Smolensky (2013)
Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation.Sleep medicine reviews, 17 4
E. Schernhammer, Candyce Kroenke, F. Laden, S. Hankinson (2006)
Night Work and Risk of Breast CancerEpidemiology, 17
K. Straif, R. Baan, Y. Grosse, B. Secretan, F. Ghissassi, V. Bouvard, A. Altieri, L. Benbrahim-Tallaa, V. Cogliano (2007)
Carcinogenicity of shift-work, painting, and fire-fighting.The Lancet. Oncology, 8 12
Elizabeth Brandon, J. Gu, L. Cantwell, Zhi He, Gray Wallace, J. Hall (2009)
Obesity promotes melanoma tumor growth: Role of leptinCancer Biology & Therapy, 8
P. Mills, L. Natarajan, R. Känel, S. Ancoli-Israel, J. Dimsdale (2009)
Diurnal variability of C-reactive protein in obstructive sleep apneaSleep & Breathing = Schlaf & Atmung, 13
G. Semenza (2012)
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy.Trends in pharmacological sciences, 33 4
Xiaoming Yang, P. Wood, Eun-Young Oh, Jovelyn Du-Quiton, Christine Ansell, W. Hrushesky (2009)
Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythmBreast Cancer Research and Treatment, 117
Brian Kit, H. Orpana, B. Graubard (2013)
Association of all-cause mortality with overweight and obesity using standard body mass index categories. A systematic review and meta-analysisBDJ, 214
T. Kubo, K. Ozasa, K. Mikami, K. Wakai, Y. Fujino, Yoshiyuki Watanabe, T. Miki, M. Nakao, K. Hayashi, Koji Suzuki, M. Mori, M. Washio, F. Sakauchi, Y. Ito, T. Yoshimura, A. Tamakoshi (2006)
Prospective cohort study of the risk of prostate cancer among rotating-shift workers: findings from the Japan collaborative cohort study.American journal of epidemiology, 164 6
T. Śliwiński, W. Rozej, A. Morawiec-Bajda, Z. Morawiec, R. Reiter, J. Błasiak (2007)
Protective action of melatonin against oxidative DNA damage: chemical inactivation versus base-excision repair.Mutation research, 634 1-2
M. Yamauchi, H. Nakano, J. Maekawa, Yukinori Okamoto, Y. Ohnishi, Takahiro Suzuki, H. Kimura (2005)
Oxidative stress in obstructive sleep apnea.Chest, 127 5
S. Hill, T. Frasch, S. Xiang, Lin Yuan, T. Duplessis, L. Mao (2009)
Molecular Mechanisms of Melatonin Anticancer EffectsIntegrative Cancer Therapies, 8
M. Wagner, R. Bjerkvig, H. Wiig, J. Melero-Martin, Ruei-Zeng Lin, M. Klagsbrun, A. Dudley (2012)
Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesisAngiogenesis, 15
M. Martínez-García, F. Campos-Rodriguez, J. Durán-Cantolla, M. Peña, M. Masdeu, Mónica González, F. Campo, P. Serra, I. Valero-Sánchez, M. Ferrer, J. Marin, F. Barbé, M. Martínez, R. Farré, R. Farré, J. Montserrat (2014)
Obstructive sleep apnea is associated with cancer mortality in younger patients.Sleep medicine, 15 7
E. Rofstad, Jon-Vidar Gaustad, T. Egeland, B. Mathiesen, Kanthi Galappathi (2010)
Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic disseminationInternational Journal of Cancer, 127
H. Taniguchi, A. Fernández, F. Setién, S. Ropero, E. Ballestar, A. Villanueva, Hiroyuki Yamamoto, K. Imai, Y. Shinomura, M. Esteller (2009)
Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.Cancer research, 69 21
E. Filipski, V. King, Xiaomei Li, T. Granda, M. Mormont, Xu-hui Liu, B. Claustrat, M. Hastings, F. Lévi (2002)
Host circadian clock as a control point in tumor progression.Journal of the National Cancer Institute, 94 9
M. Martínez-García, A. Martorell‐Calatayud, E. Nagore, Irene Valero, M. Selma, E. Chiner, P. Landete, J. Montserrat, C. Carrera, A. Pérez‐Gil, F. Campos-Rodriguez, R. Farré (2014)
Association between sleep disordered breathing and aggressiveness markers of malignant cutaneous melanomaEuropean Respiratory Journal, 43
Alex Gileles-Hillel, I. Almendros, A. Khalyfa, Shelley Zhang, Yang Wang, D. Gozal (2014)
Early intermittent hypoxia induces proatherogenic changes in aortic wall macrophages in a murine model of obstructive sleep apnea.American journal of respiratory and critical care medicine, 190 8
D. Blask, G. Brainard, R. Dauchy, J. Hanifin, L. Davidson, J. Krause, L. Sauer, M. Rivera-Bermúdez, M. Dubocovich, S. Jasser, D. Lynch, M. Rollag, F. Zalatan (2005)
Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats.Cancer research, 65 23
I. Almendros, J. Montserrat, M. Torres, M. Bonsignore, L. Chimenti, D. Navajas, R. Farré (2012)
Obesity and intermittent hypoxia increase tumor growth in a mouse model of sleep apnea.Sleep medicine, 13 10
F. Hakim, Yang Wang, Shelley Zhang, Jiamao Zheng, E. Yolcu, A. Carreras, A. Khalyfa, H. Shirwan, I. Almendros, D. Gozal (2014)
Fragmented sleep accelerates tumor growth and progression through recruitment of tumor-associated macrophages and TLR4 signaling.Cancer research, 74 5
E. Filipski, F. Delaunay, V. King, Ming-Wei Wu, B. Claustrat, A. Gréchez-Cassiau, C. Guettier, M. Hastings, Lévi Francis (2004)
Effects of Chronic Jet Lag on Tumor Progression in MiceCancer Research, 64
W. McNicholas (2009)
Obstructive sleep apnea and inflammation.Progress in cardiovascular diseases, 51 5
G. Semenza (2011)
mechanisms of disease Oxygen Sensing , Homeostasis , and Disease
T. Kendzerska, R. Leung, G. Hawker, G. Tomlinson, A. Gershon (2014)
Obstructive sleep apnea and the prevalence and incidence of cancerCanadian Medical Association Journal, 186
A. Ruesten, C. Weikert, I. Fietze, H. Boeing (2012)
Association of Sleep Duration with Chronic Diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam StudyPLoS ONE, 7
I. Almendros, J. Montserrat, M. Torres, M. Dalmases, M. Cabañas, F. Campos-Rodriguez, D. Navajas, R. Farré (2013)
Intermittent hypoxia increases melanoma metastasis to the lung in a mouse model of sleep apneaRespiratory Physiology & Neurobiology, 186
M. Kakizaki, K. Inoue, S. Kuriyama, T. Sone, Kaori Matsuda-Ohmori, Naoki Nakaya, Shin Fukudo, Ichiro Tsuji (2008)
Sleep duration and the risk of prostate cancer: the Ohsaki Cohort StudyBritish Journal of Cancer, 99
S. Davis, D. Mirick (2006)
Circadian Disruption, Shift Work and the Risk of Cancer: A Summary of the Evidence and Studies in SeattleCancer Causes & Control, 17
Simone Pinheiro, E. Schernhammer, S. Tworoger, K. Michels (2006)
A prospective study on habitual duration of sleep and incidence of breast cancer in a large cohort of women.Cancer research, 66 10
N. Marshall, Keith Wong, Stewart Cullen, M. Knuiman, R. Grunstein (2014)
Sleep apnea and 20-year follow-up for all-cause mortality, stroke, and cancer incidence and mortality in the Busselton Health Study cohort.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 10 4
A. Viswanathan, S. Hankinson, E. Schernhammer (2007)
Night shift work and the risk of endometrial cancer.Cancer research, 67 21
P. Shah, M. Mhatre, L. Kothari (1984)
Effect of melatonin on mammary carcinogenesis in intact and pinealectomized rats in varying photoperiods.Cancer research, 44 8
There is a growing evidence that sleep disorders are associated with an increased incidence and accelerated cancer progression. In the light of the previously established relationship between hypoxemia and cancer, obstructive sleep apnea and its main consequence, intermittent hypoxia, could be associated with a poorer prognosis or higher incidence of cancer. From this pathophysiological starting point, and in the light of animal studies that confirmed this association, two separate research groups observed in large-scale clinical and epidemiological series that the degree of nighttime hypoxia found in patients with obstructive sleep apnea was associated with a higher incidence of cancer, as well as a higher mortality rate although their retrospective nature means that they should be considered with caution. A study currently in progress with a large group of patients with melanoma may soon cast new light on the existence or not of this association and its underlying pathophysiological mechanisms.
Current Sleep Medicine Reports – Springer Journals
Published: Feb 11, 2016
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.