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Sleep Disorders and Cancer

Sleep Disorders and Cancer There is a growing evidence that sleep disorders are associated with an increased incidence and accelerated cancer progression. In the light of the previously established relationship between hypoxemia and cancer, obstructive sleep apnea and its main consequence, intermittent hypoxia, could be associated with a poorer prognosis or higher incidence of cancer. From this pathophysiological starting point, and in the light of animal studies that confirmed this association, two separate research groups observed in large-scale clinical and epidemiological series that the degree of nighttime hypoxia found in patients with obstructive sleep apnea was associated with a higher incidence of cancer, as well as a higher mortality rate although their retrospective nature means that they should be considered with caution. A study currently in progress with a large group of patients with melanoma may soon cast new light on the existence or not of this association and its underlying pathophysiological mechanisms. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Sleep Medicine Reports Springer Journals

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References (66)

Publisher
Springer Journals
Copyright
Copyright © 2016 by Springer International Publishing AG
Subject
Medicine & Public Health; Internal Medicine; General Practice / Family Medicine; Otorhinolaryngology; Neurology; Cardiology; Psychiatry
eISSN
2198-6401
DOI
10.1007/s40675-016-0034-3
Publisher site
See Article on Publisher Site

Abstract

There is a growing evidence that sleep disorders are associated with an increased incidence and accelerated cancer progression. In the light of the previously established relationship between hypoxemia and cancer, obstructive sleep apnea and its main consequence, intermittent hypoxia, could be associated with a poorer prognosis or higher incidence of cancer. From this pathophysiological starting point, and in the light of animal studies that confirmed this association, two separate research groups observed in large-scale clinical and epidemiological series that the degree of nighttime hypoxia found in patients with obstructive sleep apnea was associated with a higher incidence of cancer, as well as a higher mortality rate although their retrospective nature means that they should be considered with caution. A study currently in progress with a large group of patients with melanoma may soon cast new light on the existence or not of this association and its underlying pathophysiological mechanisms.

Journal

Current Sleep Medicine ReportsSpringer Journals

Published: Feb 11, 2016

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